Patents by Inventor Marc Aprahamian

Marc Aprahamian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Parovirus having a CpG-enriched genome useful for cancer therapy
    Patent number: 10098917
    Abstract: A parvovirus characterized by a CpG-enriched genome, wherein the genome contains at least 2 additional CpG inserts that are not present in the wild type genome is described as well as the use of said parvovirus, e.g., a parvovirus based on parvovirus H1, LuIII, Mouse minute virus (MMV), Mouse parvovirus (MPV), Rat minute virus (RMV), Rat parvovirus (RPV), Rat virus (RV), vectors based on the foregoing viral species, and/or cells capable of actively producing the foregoing viral species for the preparation of a pharmaceutical composition, e.g., for the treatment of cancer, preferably pancreas carcinoma, hepatoma or lymphoma.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: October 16, 2018
    Assignees: Deutsches Krebsforschungszentrum Stiftung des oeffentlichen Rechts, Ruprecht-Karls-Universiaet Heidelberg
    Inventors: Zahari Raykov, Jean Rommelaere, Nathalia Giese, Marc Aprahamian
  • Co-administration of a parvovirus and a cytokine for therapy of pancreatic cancer
    Patent number: 10058591
    Abstract: The present invention relates to a combination of a parvovirus and a cytokine, preferably IFNy, for use in treating pancreatic cancer, in particular a terminal stage of this disease.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: August 28, 2018
    Assignees: Deutsches Krebsforschungszentrum, Ruprecht-Karls-Universitaet Heidelberg
    Inventors: Zahari Raykov, Svitlana Grekova, Laurent Daeffler, Jean Rommelaere, Marc Aprahamian, Nathalia Giese
  • Oncolytic virotherapy for prevention of tumor recurrence
    Patent number: 9861669
    Abstract: Described is a parvovirus for preventing recurrence of a tumor, preferably a malignant brain tumor or pancreas tumor.
    Type: Grant
    Filed: May 19, 2010
    Date of Patent: January 9, 2018
    Assignees: Deutsches Krebsforschungszentrum Stiftung des Oeffentlichen Rechts, Ruprecht-Karls-Universitaet Heidelberg
    Inventors: Jean Rommelaere, Zahari Raykov, Svitlana Grekova, Irina Kiprijanova, Karsten Geletneky, Ute Koch, Marc Aprahamian
  • Co-Administration of a Parvovirus and a Cytokine for Therapy of Pancreatic Cancer
    Publication number: 20160082085
    Abstract: The present invention relates to a combination of a parvovirus and a cytokine, preferably IFNy, for use in treating pancreatic cancer, in particular a terminal stage of this disease.
    Type: Application
    Filed: December 3, 2015
    Publication date: March 24, 2016
    Inventors: Zahari RAYKOV, Svitlana GREKOVA, Laurent DAEFFLER, Jean ROMMELAERE, Marc APRAHAMIAN, Nathalia GIESE
  • Co-Administration of a Parvovirus and a Cytokine for Therapy of Pancreatic Cancer
    Publication number: 20140328798
    Abstract: The present invention relates to a combination of a parvovirus and a cytokine, preferably IFN?, for use in treating pancreatic cancer, in particular a terminal stage of this disease.
    Type: Application
    Filed: November 14, 2012
    Publication date: November 6, 2014
    Inventors: Zahari Raykov, Svitlana Grekova, Laurent Daeffler, Jean Rommelaere, Marc Aprahamian, Nathalia Giese
  • Parvovirus having a CPG-enriched genome useful for cancer therapy
    Patent number: 8535929
    Abstract: A parvovirus characterized by a CpG-enriched genome, wherein the genome contains at least 2 additional CpG inserts that are not present in the wild type genome is described as well as the use of said parvovirus, e.g., a parvovirus based on parvovirus H1, LuIII, Mouse minute virus (MMV), Mouse parvovirus (MPV), Rat minute virus (RMV), Rat parvovirus (RPV), Rat virus (RV), vectors based on the foregoing viral species, and/or cells capable of actively producing the foregoing viral species for the preparation of a pharmaceutical composition, e.g., for the treatment of cancer, preferably pancreas carcinoma, hepatoma or lymphoma.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: September 17, 2013
    Assignees: Deutsches Krebsforschungszentrum, Ruprecht-Karls-Universitaet Heidelberg
    Inventors: Zahari Raykov, Jean Rommelaere, Nathalia Giese, Marc Aprahamian
  • CO-ADMINISTRATION OF A PARVOVIRUS AND A CYTOKINE FOR THERAPY OF PANCREATIC CANCER
    Publication number: 20130129678
    Abstract: The application relates to a combination of a parvovirus and a cytokine, preferably IFN?, for use in treating pancreatic cancer (PDAC), in particular a terminal stage of this disease.
    Type: Application
    Filed: November 17, 2011
    Publication date: May 23, 2013
    Inventors: Zahari RAYKOV, Svitlana Grekova, Laurent Daeffler, Jean Rommelaere, Marc Aprahamian, Nathalia Giese
  • Parvovirus cancer therapy and combination with chemotherapy
    Patent number: 8414883
    Abstract: Described is a pharmaceutical composition containing (a) a parvovirus and (b) a chemotherapeutic agent, preferably as separate entities. The parvovirus might be based on parvovirus H1, LuIII, Mouse minute virus (MMV), Mouse parvovirus (MPV), Rat minute virus (RMV), Rat parvovirus (RPV), Rat virus (RV), vectors based on the foregoing viral species, and/or cells capable of actively producing the foregoing viral species. The pharmaceutical composition is beneficial for the treatment of a tumor. Tumors for which a parvovirus or the adjunction of the invention has particular utility include glioma, medulloblastoma, meningioma and pancreatic cancer. Preferred chemotherapeutic agents are gemcitabine and Temozolodine.
    Type: Grant
    Filed: December 23, 2008
    Date of Patent: April 9, 2013
    Assignees: Deutsches Krebsforschungszentrum, Ruprecht-Karls-Universitaet Heidelberg
    Inventors: Jean Rommelaere, Zahari Raykov, Joerg Schlehofer, Irina Kiprijanova, Tanja Heimberger, Assia Angelova, Karsten Geletneky, Marc Aprahamian
  • Oncolytic Virotherapy for Prevention of Tumor Recurrence
    Publication number: 20120237483
    Abstract: Described is a parvovirus for preventing recurrence of a tumor, preferably a malignant brain tumor or pancreas tumor.
    Type: Application
    Filed: May 19, 2010
    Publication date: September 20, 2012
    Applicant: Ruprecht-Karls-Universitaet Heidelberg
    Inventors: Jean Rommelaere, Zahari Raykov, Svitlana Grekova, Irina Kiprijanova, Karsten Geletneky, Ute Koch, Marc Aprahamian
  • Parvovirus Having a CPG-Enriched Genome Useful for Cancer Therapy
    Publication number: 20110033425
    Abstract: A parvovirus characterized by a CpG-enriched genome, wherein the genome contains at least 2 additional CpG inserts that are not present in the wild type genome is described as well as the use of said parvovirus, e.g., a parvovirus based on parvovirus H1, LuIII, Mouse minute virus (MMV), Mouse parvovirus (MPV), Rat minute virus (RMV), Rat parvovirus (RPV), Rat virus (RV), vectors based on the foregoing viral species, and/or cells capable of actively producing the foregoing viral species for the preparation of a pharmaceutical composition, e.g., for the treatment of cancer, preferably pancreas carcinoma, hepatoma or lymphoma.
    Type: Application
    Filed: December 19, 2008
    Publication date: February 10, 2011
    Applicant: Deutsches Krebsforschungszentrum
    Inventors: Zahari Raykov, Jean Rommelaere, Nathalia Giese, Marc Aprahamian
  • Detecting and mapping of inflamed zones in a living tissue
    Patent number: 6393315
    Abstract: A method for detecting and mapping inflamed zones in living tissues and a device for implementing the method. The method includes subjecting the tissues to be analyzed to a luminous excitation with a predetermined spectral domain, acquiring at least the raw fluorescence signal of the porphyrins for a plurality of measurement points, and in determining, for each measurement point, the intensity of the fluorescence for the wavelengths characteristic of endogenous porphyrins.
    Type: Grant
    Filed: April 5, 2000
    Date of Patent: May 21, 2002
    Assignee: Communaute Europeenne
    Inventors: Pierre Marc Aprahamian, Francine Heisel, Alfredo Lucia, Joseph-Albert Miehe, Malgorzata Sowinska, Maurice Whelan