Abstract: A machine for flatbed cutting of pieces from a strip of material (3) wound in a coil and moving continuously. The cutting zone (ZD) comprises a cutting head (17) supported by a mobile support (20) translatably mounted on a stationary longitudinal beam (18) disposed parallel to the direction of movement (A) of the strip of material. It is coupled to a first actuator (Mx) for moving the cutting head (17) linearly along a longitudinal axis (X) parallel to the beam and comprises a variable-geometry mechanism (21-24) coupled to a second actuator (My) for moving the cutting head (17) linearly along a transverse axis (Y), perpendicular to the longitudinal axis (X). A central control unit (9) controls the actuators to move the cutting head (17) in the cutting zone (ZD) along a path determined by the contour of the pieces (2) to be cut and the speed of the material (3).

Abstract: A machine for flatbed cutting of pieces from a strip of material (3) wound in a coil and moving continuously. The cutting zone (ZD) comprises a cutting head (17) supported by a mobile support (20) translatably mounted on a stationary longitudinal beam (18) disposed parallel to the direction of movement (A) of the strip of material. It is coupled to a first actuator (Mx) for moving the cutting head (17) linearly along a longitudinal axis (X) parallel to the beam and comprises a variable-geometry mechanism (21-24) coupled to a second actuator (My) for moving the cutting head (17) linearly along a transverse axis (Y), perpendicular to the longitudinal axis (X). A central control unit (9) controls the actuators to move the cutting head (17) in the cutting zone (ZD) along a path determined by the contour of the pieces (2) to be cut and the speed of the material (3).

Abstract: The present invention relates to gene promoters whose methylation status correlates with the clinical survival outcome of glioblastoma patients treated according to the Stupp protocol. More specifically, the invention provides methods and kits for the prognosis of survival outcome and/or treatment response in glioblastoma patients.

Abstract: The present invention relates to the identification and use of biomarkers with clinical relevance to high grade gliomas (HGGs). In particular, the invention provides the identity of four genes, CHAF1B, PDLIM4, EDNRB and HJURP, whose expression, at the transcriptome and proteome levels, is correlated with HGG grading and clinical survival outcome. Methods and kits are provided for using these biomarkers in the prognostication of HGGs, and in the selection and/or monitoring of treatment regimens.

Abstract: A device (1) for straightening a strip of semi-rigid material and feeding the strip into a machine, in particular a metallic sheet into a press or the like. The device comprises a lower frame (3) which carries a set of lower straightening rolls (30), an upper frame (4) which carries a set of upper straightening rolls (40) arranged staggered relative to the lower straightening rolls (30), and a traction mechanism (5) for the strip of material arranged both upstream and downstream from the sets of straightening rolls (30, 40).