Patents by Inventor Marc B. Garnick
Marc B. Garnick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10500935Abstract: Methods and devices are provided for vehicle covers. For example, a method of covering a vehicle is provided including placing a pre-folded vehicle cover between front and rear wheels of the vehicle and then driving the vehicle forwards until the rear wheels of the vehicle are on top of the vehicle cover. The method includes extending a rear portion of the vehicle cover and driving the vehicle backwards until the front wheels of the vehicle are on top of the vehicle cover. The method further includes extending a front portion of the vehicle cover and covering at least a bottom and at least part of each side of the vehicle with the vehicle cover to form a barrier underneath and at least partially around the vehicle. The method can also include covering a top of the vehicle and entirely enclosing the vehicle.Type: GrantFiled: July 30, 2018Date of Patent: December 10, 2019Assignee: VPROTECH, INC.Inventor: Marc B. Garnick
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Publication number: 20180334020Abstract: Methods and devices are provided for vehicle covers. For example, a method of covering a vehicle is provided including placing a pre-folded vehicle cover between front and rear wheels of the vehicle and then driving the vehicle forwards until the rear wheels of the vehicle are on top of the vehicle cover. The method includes extending a rear portion of the vehicle cover and driving the vehicle backwards until the front wheels of the vehicle are on top of the vehicle cover. The method further includes extending a front portion of the vehicle cover and covering at least a bottom and at least part of each side of the vehicle with the vehicle cover to form a barrier underneath and at least partially around the vehicle. The method can also include covering a top of the vehicle and entirely enclosing the vehicle.Type: ApplicationFiled: July 30, 2018Publication date: November 22, 2018Inventor: Marc B. Garnick
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Patent number: 10035412Abstract: Methods and devices are provided for using vehicle covers. For example, a method of covering a vehicle is provided including placing a pre-folded vehicle cover between front and rear wheels of the vehicle and then driving the vehicle forwards until the rear wheels of the vehicle are on top of the vehicle cover. The method includes extending a rear portion of the vehicle cover and driving the vehicle backwards until the front wheels of the vehicle are on top of the vehicle cover. The method further includes extending a front portion of the vehicle cover and covering at least a bottom and at least part of each side of the vehicle with the vehicle cover to form a barrier underneath and at least partially around the vehicle. The method can also include covering a top of the vehicle and entirely enclosing the vehicle.Type: GrantFiled: May 26, 2017Date of Patent: July 31, 2018Inventor: Marc B. Garnick
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Publication number: 20170341497Abstract: Methods and devices are provided for using vehicle covers. For example, a method of covering a vehicle is provided including placing a pre-folded vehicle cover between front and rear wheels of the vehicle and then driving the vehicle forwards until the rear wheels of the vehicle are on top of the vehicle cover. The method includes extending a rear portion of the vehicle cover and driving the vehicle backwards until the front wheels of the vehicle are on top of the vehicle cover. The method further includes extending a front portion of the vehicle cover and covering at least a bottom and at least part of each side of the vehicle with the vehicle cover to form a barrier underneath and at least partially around the vehicle. The method can also include covering a top of the vehicle and entirely enclosing the vehicle.Type: ApplicationFiled: May 26, 2017Publication date: November 30, 2017Inventor: Marc B. Garnick
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Publication number: 20110009343Abstract: Compounds that modulate the aggregation of amyloidogenic proteins or peptides are disclosed. The modulators of the invention can promote amyloid aggregation or, more preferably, can inhibit natural amyloid aggregation. In a preferred embodiment, the compounds modulate the aggregation of natural ? amyloid peptides (?-AP). In a preferred embodiment, the ? amyloid modulator compounds of the invention are comprised of an A? aggregation core domain and a modifying group coupled thereto such that the compound alters the aggregation or inhibits the neurotoxicity of natural ? amyloid peptides when contacted with the peptides. Furthermore, the modulators are capable of altering natural ?-AP aggregation when the natural ?-APs are in a molar excess amount relative to the modulators. Pharmaceutical compositions comprising the compounds of the invention, and diagnostic and treatment methods for amyloidogenic diseases using the compounds of the invention, are also disclosed.Type: ApplicationFiled: December 21, 2009Publication date: January 13, 2011Applicant: Praecis Pharmaceuticals, Inc.Inventors: Mark A. Findeis, Howard Benjamin, Marc B. Garnick, Malcolm L. Gefter, Arvind Hundal, Laura Kasman, Gary Musso, Ethan R. Signer, James Wakefield, Michael J. Reed
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Patent number: 7658917Abstract: Compounds that modulate the aggregation of amyloidogenic proteins or peptides are disclosed. The modulators of the invention can promote amyloid aggregation or, more preferably, can inhibit natural amyloid aggregation. In a preferred embodiment, the compounds modulate the aggregation of natural ? amyloid peptides (?-AP). In a preferred embodiment, the ? amyloid modulator compounds of the invention are comprised of an A? aggregation core domain and a modifying group coupled thereto such that the compound alters the aggregation or inhibits the neurotoxicity of natural ? amyloid peptides when contacted with the peptides. Furthermore, the modulators are capable of altering natural ?-AP aggregation when the natural ?-APs are in a molar excess amount relative to the modulators. Pharmaceutical compositions comprising the compounds of the invention, and diagnostic and treatment methods for amyloidogenic diseases using the compounds of the invention, are also disclosed.Type: GrantFiled: June 17, 2003Date of Patent: February 9, 2010Assignee: Praecis Pharmaceuticals, Inc.Inventors: Mark A. Findeis, Howard Benjamin, Marc B. Garnick, Malcolm L. Gefter, Arvind Hundal, Ethan R. Signer, James Wakefield, Laura Kasman, Gary Musso, Michael J. Reed
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Publication number: 20090197813Abstract: Methods for treating FSH related conditions, such as prostatic intraepithelial neoplasia, pedophilia, infertility, or vaginal bleeding, with GnRH antagonists are disclosed. The methods of the invention generally feature administering to a subject a GnRH antagonist suitable for in vivo administration and able to reduce both plasma FSH and LH levels in a subject, in an amount or in a formulation effective to reduce plasma FSH levels in the subject to a symptom alleviating level. In vitro fertilization and male contraceptive methods are also provided.Type: ApplicationFiled: December 3, 2008Publication date: August 6, 2009Inventors: Marc B. Garnick, Paul M. Martha, JR., Christopher J. Molineaux, Alex DePaoli
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Patent number: 7109171Abstract: Methods for treating FSH related conditions, such as prostatic intraepithelial neoplasia, pedophilia, infertility, or vaginal bleeding, with GnRH antagonists are disclosed. The methods of the invention generally feature administering to a subject a GnRH antagonist suitable for in vivo administration and able to reduce both plasma FSH and LH levels in a subject, in an amount or in a formulation effective to reduce plasma FSH levels in the subject to a symptom alleviating level. In vitro fertilization and male contraceptive methods are also provided.Type: GrantFiled: February 28, 2001Date of Patent: September 19, 2006Assignee: Praecis Pharmaceuticals Inc.Inventors: Marc B. Garnick, Paul M. Martha, Jr., Christopher J. Molineaux, Alex DePaoli
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Publication number: 20040110689Abstract: Methods for treating hormone associated conditions, such as endometriosis, uterine leiomata, ovarian cancer, breast cancer, or vaginal bleeding, using LHRH antagonists and selective estrogen receptor modulators are disclosed. The methods include administering to a subject a combination of an LHRH antagonist and a selective estrogen receptor modulator. Pharmaceutical compositions and kits for use in the methods of the invention are also provided.Type: ApplicationFiled: July 14, 2003Publication date: June 10, 2004Applicant: Praecis Pharmaceuticals, Inc.Inventor: Marc B. Garnick
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Patent number: 6737039Abstract: Improved methods for detecting lesions in dense breast tissue are disclosed. The methods of the invention generally feature administration to a subject of an LHRH antagonist in an amount and for a period of time sufficient to reduce the density of breast tissue prior to generating an image of the breast tissue, for example by mammography, to detect a lesion in the breast tissue. Packaged formulations for reducing breast density in a subject prior to generating an image of the subject's breast tissue, comprising an LHRH antagonist packaged with instructions for using the LHRH antagonist to reduce breast density in a subject prior to imaging the breast tissue, are also disclosed.Type: GrantFiled: December 12, 2002Date of Patent: May 18, 2004Assignee: Praecis Pharmaceutics, Inc.Inventor: Marc B. Garnick
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Patent number: 6703367Abstract: Methods to inhibit hot flashes or gynaecomastia in a subject are provided. In the methods of the invention, an LHRH antagonist is administered to a subject in need of treatment for hot flashes or gynaecomastia such that hot flashes or gynaecomastia are inhibited in the subject. In a particularly preferred embodiment, the invention provides a method for inhibiting menopause-related hot flashes in which an LHRH antagonist is administered to a subject in need of treatment for menopause-related hot flashes such that the hot flashes are inhibited in the subject.Type: GrantFiled: February 16, 2001Date of Patent: March 9, 2004Assignee: Praecis Pharmaceuticals Inc.Inventor: Marc B. Garnick
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Publication number: 20040005307Abstract: Compounds that modulate the aggregation of amyloidogenic proteins or peptides are disclosed. The modulators of the invention can promote amyloid aggregation or, more preferably, can inhibit natural amyloid aggregation. In a preferred embodiment, the compounds modulate the aggregation of natural &bgr; amyloid peptides (&bgr;-AP). In a preferred embodiment, the &bgr; amyloid modulator compounds of the invention are comprised of an A&bgr; aggregation core domain and a modifying group coupled thereto such that the compound alters the aggregation or inhibits the neurotoxicity of natural &bgr; amyloid peptides when contacted with the peptides. Furthermore, the modulators are capable of altering natural &bgr;-AP aggregation when the natural &bgr;-APs are in a molar excess amount relative to the modulators. Pharmaceutical compositions comprising the compounds of the invention, and diagnostic and treatment methods for amyloidogenic diseases using the compounds of the invention, are also disclosed.Type: ApplicationFiled: June 17, 2003Publication date: January 8, 2004Applicant: Praecis Pharmaceuticals, Inc.Inventors: Mark A. Findeis, Howard Benjamin, Marc B. Garnick, Malcolm L. Gefter, Arvind Hundal, Laura Kasman, Gary Musso, Ethan R. Signer, James Wakefield, Michael J. Reed
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Publication number: 20030086870Abstract: Improved methods for detecting lesions in dense breast tissue are disclosed. The methods of the invention generally feature administration to a subject of an LHRH antagonist in an amount and for a period of time sufficient to reduce the density of breast tissue prior to generating an image of the breast tissue, for example by mammography, to detect a lesion in the breast tissue. Packaged formulations for reducing breast density in a subject prior to generating an image of the subject's breast tissue, comprising an LHRH antagonist packaged with instructions for using the LHRH antagonist to reduce breast density in a subject prior to imaging the breast tissue, are also disclosed.Type: ApplicationFiled: December 12, 2002Publication date: May 8, 2003Applicant: Praecis Pharmaceuticals Inc.Inventor: Marc B. Garnick
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Patent number: 6540979Abstract: Improved methods for detecting lesions in dense breast tissue are disclosed. The methods of the invention generally feature administration to a subject of an LHRH antagonist in an amount and for a period of time sufficient to reduce the density of breast tissue prior to generating an image of the breast tissue, for example by mammography, to detect a lesion in the breast tissue. Packaged formulations for reducing breast density in a subject prior to generating an image of the subject's breast tissue, comprising an LHRH antagonist packaged with instructions for using the LHRH antagonist to reduce breast density in a subject prior to imaging the breast tissue, are also disclosed.Type: GrantFiled: January 18, 2001Date of Patent: April 1, 2003Assignee: Praecis Pharmaceuticals, Inc.Inventor: Marc B. Garnick
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Publication number: 20020098173Abstract: Compounds that modulate the aggregation of amyloidogenic proteins or peptides are disclosed. The modulators of the invention can promote amyloid aggregation or, more preferably, can inhibit natural amyloid aggregation. In a preferred embodiment, the compounds modulate the aggregation of natural &bgr; amyloid peptides (&bgr;-AP). In a preferred embodiment, the &bgr; amyloid modulator compounds of the invention are comprised of an A&bgr; aggregation core domain and a modifying group coupled thereto such that the compound alters the aggregation or inhibits the neurotoxicity of natural &bgr; amyloid peptides when contacted with the peptides. Furthermore, the modulators are capable of altering natural &bgr;-AP aggregation when the natural &bgr;-APs are in a molar excess amount relative to the modulators. Pharmaceutical compositions comprising the compounds of the invention, and diagnostic and treatment methods for amyloidogenic diseases using the compounds of the invention, are also disclosed.Type: ApplicationFiled: October 4, 2001Publication date: July 25, 2002Applicant: Praecis Pharmaceuticals, Inc.Inventors: Mark A. Findeis, Howard Benjamin, Marc B. Garnick, Malcolm L. Gefter, Arvind Hundal, Laura Kasman, Gary Musso, Ethan R. Signer, James Wakefield, Michael J. Reed
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Publication number: 20020058035Abstract: Methods for treating FSH related conditions, such as prostatic intraepithelial neoplasia, pedophilia, infertility, or vaginal bleeding, with GnRH antagonists are disclosed. The methods of the invention generally feature administering to a subject a GnRH antagonist suitable for in vivo administration and able to reduce both plasma FSH and LH levels in a subject, in an amount or in a formulation effective to reduce plasma FSH levels in the subject to a symptom alleviating level. In vitro fertilization and male contraceptive methods are also provided.Type: ApplicationFiled: February 27, 2001Publication date: May 16, 2002Inventors: Marc B. Garnick, Paul M. Martha, Christopher J. Molineaux, Alex DePaoli
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Patent number: 6384017Abstract: Methods for treating prostate cancer are disclosed. The methods of the invention generally feature administration to a subject of an LHRH-R antagonist, in combination with a second therapy. In one embodiment, this second therapy is performance of a procedure that removes or destroys prostatic tumor tissue, such as a radical prostatectomy, cryosurgery or X-ray therapy (external or interstitial). In another embodiment, the second therapy is treatment with an LHRH-R agonist, either simultaneous with or subsequent to LHRH-R antagonist therapy. The methods of the invention can further involve administering an antiandrogen and/or an inhibitor of sex steroid biosynthesis to the subject in combination with the LHRH-R antagonist.Type: GrantFiled: October 26, 2000Date of Patent: May 7, 2002Assignee: Praecis Pharmaceuticals, Inc.Inventors: Marc B. Garnick, Christopher J. Molineaux, Malcolm L. Gefter
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Patent number: 6319498Abstract: Compounds that modulate the aggregation of amyloidogenic proteins or peptides are disclosed. The modulators of the invention can promote amyloid aggregation or, more preferably, can inhibit natural amyloid aggregation. In a preferred embodiment, the compounds modulate the aggregation of natural &bgr; amyloid peptides (&bgr;-AP). In a preferred embodiment, the &bgr; amyloid modulator compounds of the invention are comprised of an A&bgr; aggregation core domain and a modifying group coupled thereto such that the compound alters the aggregation or inhibits the neurotoxicity of natural &bgr; amyloid peptides when contacted with the peptides. Furthermore, the modulators are capable of altering natural &bgr;-AP aggregation when the natural &bgr;-APs are in a molar excess amount relative to the modulators. Pharmaceutical compositions comprising the compounds of the invention, and diagnostic and treatment methods for amyloidogenic diseases using the compounds of the invention, are also disclosed.Type: GrantFiled: March 14, 1996Date of Patent: November 20, 2001Assignee: Praecis Pharmaceuticals IncorporatedInventors: Mark A. Findeis, Howard Benjamin, Marc B. Garnick, Malcolm L. Gefter, Arvind Hundal, Laura Kasman, Gary Musso, Ethan R. Signer, James Wakefield, Michael J. Reed
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Publication number: 20010002249Abstract: Improved methods for detecting lesions in dense breast tissue are disclosed. The methods of the invention generally feature administration to a subject of an LHRH antagonist in an amount and for a period of time sufficient to reduce the density of breast tissue prior to generating an image of the breast tissue, for example by mammography, to detect a lesion in the breast tissue. Packaged formulations for reducing breast density in a subject prior to generating an image of the subject's breast tissue, comprising an LHRH antagonist packaged with instructions for using the LHRH antagonist to reduce breast density in a subject prior to imaging the breast tissue, are also disclosed.Type: ApplicationFiled: January 18, 2001Publication date: May 31, 2001Applicant: Praecis Pharmaceuticals IncorporatedInventor: Marc B. Garnick
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Patent number: 6217844Abstract: Improved methods for detecting lesions in dense breast tissue are disclosed. The methods of the invention generally feature administration to a subject of an LHRH antagonist in an amount and for a period of time sufficient to reduce the density of breast tissue prior to generating an image of the breast tissue, for example by mammography, to detect a lesion in the breast tissue. Packaged formulations for reducing breast density in a subject prior to generating an image of the subject's breast tissue, comprising an LHRH antagonist packaged with instructions for using the LHRH antagonist to reduce breast density in a subject prior to imaging the breast tissue, are also disclosed.Type: GrantFiled: April 27, 1998Date of Patent: April 17, 2001Assignee: Praecis Pharmaceuticals, Inc.Inventor: Marc B. Garnick