Patents by Inventor Marc Bellotti
Marc Bellotti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7375191Abstract: The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.Type: GrantFiled: March 8, 2004Date of Patent: May 20, 2008Assignee: Lipid Science, Inc.Inventors: Marc Bellotti, H. Bryan Brewer, Jr., Hassibullah Akeefe, Adam Paul Conner, Timothy Jon Perlman
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Patent number: 7361739Abstract: The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.Type: GrantFiled: November 23, 2004Date of Patent: April 22, 2008Assignee: Lipid Sciences, Inc.Inventors: Marc Bellotti, H. Bryan Brewer, Jr., Hassibullah Akeefe, Adam Paul Conner, Timothy Jon Perlman
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Publication number: 20060172939Abstract: The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.Type: ApplicationFiled: October 26, 2005Publication date: August 3, 2006Inventors: Marc Bellotti, H. Brewer, Hassibullah Akeefe, Adam Conner, Timothy Perlman
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Publication number: 20050090444Abstract: The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.Type: ApplicationFiled: November 23, 2004Publication date: April 28, 2005Inventors: Marc Bellotti, H. Brewer, Hassibullah Akeefe, Adam Conner, Timothy Perlman
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Publication number: 20050032222Abstract: The present invention relates to a method for reducing the occurrence and severity of infectious diseases, especially infectious diseases in which lipid-containing infectious viral organisms are found in biological fluids, such as blood. The present invention employs solvents useful for extracting lipids from the lipid-containing infectious viral organism thereby creating modified viral particles with reduced infectivity and enhanced antigenicity. The present invention provides vaccine compositions, comprising these modified viral particles with reduced infectivity and enhanced antigenicity, optionally combined with a pharmaceutically acceptable carrier or an immunostimulant. The vaccine composition is administered to a patient to provide protection against the lipid-containing infectious viral organism. The vaccine compositions of the present invention include combination vaccines of modified viral particles obtained from one or more strains of a virus and/or one or more types of virus.Type: ApplicationFiled: June 21, 2004Publication date: February 10, 2005Inventors: Bill Cham, Jo-Ann Maltais, Marc Bellotti
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Publication number: 20050004004Abstract: The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.Type: ApplicationFiled: March 8, 2004Publication date: January 6, 2005Inventors: Marc Bellotti, H. Brewer, Hassibullah Akeefe, Adam Conner, Timothy Perlman
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Patent number: 6712095Abstract: A vacuum demand valve for delivering a flowable material is disclosed. The valve has a housing having a proximal end, a distal end, an intermediate segment therebetween defining a passageway wherein the flowable substance can flow from the proximal end to the distal end. The housing can be a tubing. A valve member is located along the intermediate segment. The valve member has a closed condition wherein the flow of the flowable material from the proximal end to the distal end is stopped and an open condition wherein the flow of the flowable material from the proximal end to the distal end is unstopped. The valve member is biased in the closed condition and is responsive to a partial vacuum provided by the user through the passageway for placing the valve member in the open condition.Type: GrantFiled: October 7, 2002Date of Patent: March 30, 2004Assignee: Baxter International Inc.Inventors: Mark E. Williamson, Scott R. Ariagno, Alan W. Marttila, Arnold C. Bilstad, Paul M. DiPerna, Michael R. Prisco, David W. Pennington, Atif M. Yardimci, Sidney T. Smith, Mark C. Perry, Marc Bellotti
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Patent number: 6672333Abstract: A vacuum demand valve for delivering a flowable material is disclosed. The valve has a housing having a proximal end, a distal end, an intermediate segment therebetween defining a passageway wherein the flowable substance can flow from the proximal end to the distal end. The housing can be a tubing. A valve member is located along the intermediate segment. The valve member has a closed condition wherein the flow of the flowable material from the proximal end to the distal end is stopped and an open condition wherein the flow of the flowable material from the proximal end to the distal end is unstopped. The valve member is biased in the closed condition and is responsive to a partial vacuum provided by the user through the passageway for placing the valve member in the open condition.Type: GrantFiled: October 7, 2002Date of Patent: January 6, 2004Assignee: Baxter International Inc.Inventors: Mark E. Williamson, Scott R. Ariagno, Alan W. Marttila, Arnold C. Bilstad, Paul M. DiPerna, Michael R. Prisco, David W. Pennington, Atif M. Yardimci, Sidney T. Smith, Mark C. Perry, Marc Bellotti
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Patent number: 6604545Abstract: A vacuum demand valve for delivering a flowable material is disclosed. The valve has a housing having a proximal end, a distal end, an intermediate segment therebetween defining a passageway wherein the flowable substance can flow from the proximal end to the distal end. The housing can be a tubing. A valve member is located along the intermediate segment. The valve member has a closed condition wherein the flow of the flowable material from the proximal end to the distal end is stopped and an open condition wherein the flow of the flowable material from the proximal end to the distal end is unstopped. The valve member is biased in the closed condition and is responsive to a partial vacuum provided by the user through the passageway for placing the valve member in the open condition.Type: GrantFiled: October 7, 2002Date of Patent: August 12, 2003Assignee: Baxter International Inc.Inventors: Mark E. Williamson, Scott R. Ariagno, Alan W. Marttila, Arnold C. Bilstad, Paul M. DiPerna, Michael R. Prisco, David W. Pennington, Atif M. Yardimci, Sidney T. Smith, Mark C. Perry, Marc Bellotti
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Patent number: 6550493Abstract: A vacuum demand value (10) is capable of delivering a flowable material. The valve (10) has a housing (11) having a proximal end (14), a distal end (16), an intermediate segment (18) therebetween defining a passageway (24) wherein the flowable substance can flow from the proximal end (14) to the distal end (16). The housing (11) can be tubing. A valve member (20) is located along the intermediate segment (18). The valve member (20) has a closed condition wherein the flowable material from the proximal end (14) to the distal end (16) is stopped and an open condition wherein the flow of the flowable material from the proximal end (14) to the distal end (16) is unstopped. The valve member (20) is biased in the closed condition and is responsive to a partial vacuum provided by the user through the passageway (24) for placing the valve member (20) in the open condition.Type: GrantFiled: June 13, 2001Date of Patent: April 22, 2003Assignee: Baxter International Inc.Inventors: Mark E. Williamson, Scott R. Ariagno, Alan W. Marttila, Arnold C. Bilstad, Paul M. DiPerna, Michael R. Prisco, David W. Pennington, Atif M. Yardimci, Sidney T. Smith, Mark C. Perry, Marc Bellotti
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Publication number: 20030037820Abstract: A vacuum demand valve for delivering a flowable material is disclosed. The valve has a housing having a proximal end, a distal end, an intermediate segment therebetween defining a passageway wherein the flowable substance can flow from the proximal end to the distal end. The housing can be a tubing. A valve member is located along the intermediate segment. The valve member has a closed condition wherein the flow of the flowable material from the proximal end to the distal end is stopped and an open condition wherein the flow of the flowable material from the proximal end to the distal end is unstopped. The valve member is biased in the closed condition and is responsive to a partial vacuum provided by the user through the passageway for placing the valve member in the open condition.Type: ApplicationFiled: October 7, 2002Publication date: February 27, 2003Inventors: Mark E. Williamson, Scott R. Ariagno, Alan W. Marttila, Arnold C. Bilstad, Paul M. DiPerna, Michael R. Prisco, David W. Pennington, Atif M. Yardimci, Sidney T. Smith, Mark C. Perry, Marc Bellotti
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Publication number: 20030029501Abstract: A vacuum demand valve for delivering a flowable material is disclosed. The valve has a housing having a proximal end, a distal end, an intermediate segment therebetween defining a passageway wherein the flowable substance can flow from the proximal end to the distal end. The housing can be a tubing. A valve member is located along the intermediate segment. The valve member has a closed condition wherein the flow of the flowable material from the proximal end to the distal end is stopped and an open condition wherein the flow of the flowable material from the proximal end to the distal end is unstopped. The valve member is biased in the closed condition and is responsive to a partial vacuum provided by the user through the passageway for placing the valve member in the open condition.Type: ApplicationFiled: October 7, 2002Publication date: February 13, 2003Inventors: Mark E. Williamson, Scott R. Ariagno, Alan W. Marttila, Arnold C. Bilstad, Paul M. DiPerna, Michael R. Prisco, David W. Pennington, Atif M. Yardimci, Sidney T. Smith, Mark C. Perry, Marc Bellotti
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Publication number: 20030029502Abstract: A vacuum demand valve for delivering a flowable material is disclosed. The valve has a housing having a proximal end, a distal end, an intermediate segment therebetween defining a passageway wherein the flowable substance can flow from the proximal end to the distal end. The housing can be a tubing. A valve member is located along the intermediate segment. The valve member has a closed condition wherein the flow of the flowable material from the proximal end to the distal end is stopped and an open condition wherein the flow of the flowable material from the proximal end to the distal end is unstopped. The valve member is biased in the closed condition and is responsive to a partial vacuum provided by the user through the passageway for placing the valve member in the open condition.Type: ApplicationFiled: October 7, 2002Publication date: February 13, 2003Inventors: Mark E. Williamson, Scott R. Ariagno, Alan W. Marttila, Arnold C. Bilstad, Paul M. DiPerna, Michael R. Prisco, David W. Pennington, Atif M. Yardimci, Sidney T. Smith, Mark C. Perry, Marc Bellotti
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Publication number: 20030029500Abstract: A vacuum demand valve for delivering a flowable material is disclosed. The valve has a housing having a proximal end, a distal end, an intermediate segment therebetween defining a passageway wherein the flowable substance can flow from the proximal end to the distal end. The housing can be a tubing. A valve member is located along the intermediate segment. The valve member has a closed condition wherein the flow of the flowable material from the proximal end to the distal end is stopped and an open condition wherein the flow of the flowable material from the proximal end to the distal end is unstopped. The valve member is biased in the closed condition and is responsive to a partial vacuum provided by the user through the passageway for placing the valve member in the open condition.Type: ApplicationFiled: October 7, 2002Publication date: February 13, 2003Inventors: Mark E. Williamson, Scott R. Ariagno, Alan W. Marttila, Arnold C. Bilstad, Paul M. DiPerna, Michael R. Prisco, David W. Pennington, Atif M. Yardimci, Sidney T. Smith, Mark C. Perry, Marc Bellotti
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Publication number: 20030029503Abstract: A vacuum demand valve for delivering a flowable material is disclosed. The valve has a housing having a proximal end, a distal end, an intermediate segment therebetween defining a passageway wherein the flowable substance can flow from the proximal end to the distal end. The housing can be a tubing. A valve member is located along the intermediate segment. The valve member has a closed condition wherein the flow of the flowable material from the proximal end to the distal end is stopped and an open condition wherein the flow of the flowable material from the proximal end to the distal end is unstopped. The valve member is biased in the closed condition and is responsive to a partial vacuum provided by the user through the passageway for placing the valve member in the open condition.Type: ApplicationFiled: October 7, 2002Publication date: February 13, 2003Inventors: Mark E. Williamson, Scott R. Ariagno, Alan W. Marttila, Arnold C. Bilstad, Paul M. DiPerna, Michael R. Prisco, David W. Pennington, Atif M. Yardimci, Sidney T. Smith, Mark C. Perry, Marc Bellotti
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Publication number: 20030024575Abstract: A vacuum demand valve for delivering a flowable material is disclosed. The valve has a housing having a proximal end, a distal end, an intermediate segment therebetween defining a passageway wherein the flowable substance can flow from the proximal end to the distal end. The housing can be a tubing. A valve member is located along the intermediate segment. The valve member has a closed condition wherein the flow of the flowable material from the proximal end to the distal end is stopped and an open condition wherein the flow of the flowable material from the proximal end to the distal end is unstopped. The valve member is biased in the closed condition and is responsive to a partial vacuum provided by the user through the passageway for placing the valve member in the open condition.Type: ApplicationFiled: October 7, 2002Publication date: February 6, 2003Inventors: Mark E. Williamson, Scott R. Ariagno, Alan W. Marttila, Arnold C. Bilstad, Paul M. DiPerna, Michael R. Prisco, David W. Pennington, Atif M. Yardimci, Sidney T. Smith, Mark C. Perry, Marc Bellotti
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Publication number: 20020189684Abstract: A vacuum demand valve for delivering a flowable material is disclosed. The valve has a housing having a proximal end, a distal end, an intermediate segment therebetween defining a passageway wherein the flowable substance can flow from the proximal end to the distal end. The housing can be a tubing. A valve member is located along the intermediate segment. The valve member has a closed condition wherein the flow of the flowable material from the proximal end to the distal end is stopped and an open condition wherein the flow of the flowable material from the proximal end to the distal end is unstopped. The valve member is biased in the closed condition and is responsive to a partial vacuum provided by the user through the passageway for placing the valve member in the open condition.Type: ApplicationFiled: June 13, 2001Publication date: December 19, 2002Inventors: Mark E. Williamson, Scott R. Ariagno, Alan W. Marttila, Arnold C. Bilstad, Paul M. DiPerna, Michael R. Prisco, David W. Pennington, Atif M. Yardimci, Sidney T. Smith, Mark C. Perry, Marc Bellotti
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Patent number: 6338738Abstract: The present invention is directed to a new and useful device and method for stabilizing cardiac tissue at a surgical site during heart surgery, and specifically useful during beating heart surgery. The device includes a foot for contacting a heart tissue and two arms movably connected together for selective movement to vary and adjust the position of the foot on the heart. The foot and the arm assembly are designed to optimize stability of the foot in contact with heart tissue, and therefore, to optimize stability of the heart during surgical procedure. The device is capable of being mounted on a chest spreader. The foot has a bottom surface which is angled for better stabilization and engagement with the heart.Type: GrantFiled: August 31, 1999Date of Patent: January 15, 2002Assignee: Edwards Lifesciences Corp.Inventors: Marc Bellotti, Alan W. Marttila, Kenneth J. Steele, Scott R. Ariagno, Atif M. Yardimci, Donald R. Heslington, Charles R. Weyrauch, Lise J. Herriott, Donald A. Smith, Cristina J. Stadler
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Patent number: 5876396Abstract: A system and a method for administering a solution (12) from a container (10) to a patient (35) are provided. The container (10) is divided into a solution side (16) and a drain side (18) separated by a tear line (20). The solution side (16) and the drain side (18) are in fluid communication with one another and with a port (28) that connects to the patient (35). The container (10) is separable at the tear line (20) such that contents of a peritoneum cavity of the patient (35) may be drained into the drain side (18) of the container (10). Then, the solution (12) from the solution side (16) of the container (10) may be drained from the container (10) into the patient (35).Type: GrantFiled: September 27, 1996Date of Patent: March 2, 1999Assignee: Baxter International Inc.Inventors: Ying-Cheng Lo, Marc Bellotti
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Patent number: 5865793Abstract: A system and a method for administering a solution (12) from a container (10) to a patient (35) are provided. The container (10) is divided into a solution side (16) and a drain side (18) separated by a tear line (20). The solution side (16) and the drain side (18) are in fluid communication with one another and with a port (28) that connects to the patient (35). The container (10) is separable at the tear line (20) such that contents of a peritoneum cavity of the patient (35) may be drained into the drain side (18) of the container (10). Then, the solution (12) from the solution side (16) of the container (10) may be drained from the container (10) into the patient (35).Type: GrantFiled: September 2, 1997Date of Patent: February 2, 1999Assignee: Baxter International Inc.Inventors: Ying-Cheng Lo, Marc Bellotti