Patents by Inventor Marc Buehler

Marc Buehler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibition of autism spectrum disorder using ribosomal read-through compounds
    Patent number: 11213537
    Abstract: The present invention relates to the novel use of read-through compounds for use in the treatment and/or prevention of Autism Spectrum Disorder.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: January 4, 2022
    Assignee: FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH
    Inventors: Marc Buehler, Veronica Ostapcuk
  • INHIBITION OF AUTISM SPECTRUM DISORDER USING RIBOSOMAL READ-THROUGH COMPOUNDS
    Publication number: 20200261484
    Abstract: The present invention relates to the novel use of read-through compounds for use in the treatment and/or prevention of Autism Spectrum Disorder.
    Type: Application
    Filed: September 17, 2018
    Publication date: August 20, 2020
    Inventors: Marc BUEHLER, Veronica OSTAPCUK
  • Methods for triggering de novo formation of heterochromatin and or epigenetic silencing with small RNAS
    Patent number: 10308935
    Abstract: The present application relates to a method for the targeted formation of heterochromatin and/or induction of epigenetic gene silencing in a cell using a small RNA, said method comprising the step of inhibiting the Paf1 complex in said cell and the step of contacting said cell with a small RNA targeted to a region of the genome of the cell, said region being the region where heterochromatin formation and/or induction of epigenetic gene silencing should be induced.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: June 4, 2019
    Assignee: FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH
    Inventors: Marc Buehler, Katarzyna Kowalik, Yukiko Shimada
  • METHODS FOR TRIGGERING DE NOVO FORMATION OF HETEROCHROMATIN AND OR EPIGENETIC SILENCING WITH SMALL RNAS
    Publication number: 20170152514
    Abstract: The present application relates to a method for the targeted formation of heterochromatin and/or induction of epigenetic gene silencing in a cell using a small RNA, said method comprising the step of inhibiting the Paf1 complex in said cell and the step of contacting said cell with a small RNA targeted to a region of the genome of the cell, said region being the region where heterochromatin formation and/or induction of epigenetic gene silencing should be induced.
    Type: Application
    Filed: June 22, 2015
    Publication date: June 1, 2017
    Inventors: Marc BUEHLER, Katarzyna KOWALIK, Yukiko SHIMADA
  • PREDICTION OF PREECLAMPSIA USING MICRORNA
    Publication number: 20160369343
    Abstract: The application relates to a method for predicting a risk for preeclampsia in a subject, said method comprising analysing a sample from the subject for the level of expression of miR455 and comparing the level of expression of miR455 in the sample from the subject to the levels of miR455 in a control sample, wherein a significantly lower expression of miR455 as compared to the expression of miR455 in the control is indicative of a risk for preeclampsia.
    Type: Application
    Filed: February 26, 2015
    Publication date: December 22, 2016
    Inventors: Marc BUEHLER, Sebastien LALEVEE, Olav LAPAIRE
  • New screening method for the treatment Friedreich's ataxia
    Publication number: 20160178610
    Abstract: The present application provides a screening method for compounds useful for the treatment of Friedreich's ataxia, and a method for the treatment of Friedreich's ataxia.
    Type: Application
    Filed: August 5, 2014
    Publication date: June 23, 2016
    Inventors: Marc BUEHLER, Loren MIRAGLIA, Lauren Gilchrist MONOVICH, Anthony ORTH, Buu TU
  • ANTI-FUNGAL-AGENTS
    Publication number: 20140093506
    Abstract: The present application relates to methods for reducing growth of a fungus having a coordination complex formed at the C-terminus of its dicer (dicer 1, ribonuclease type III) between an anion and the amino acids corresponding to the amino acids C1275, H1312, C1350 and C1352 of Dcr1 of S. pombe (fission yeast) comprising the step of contacting a fungal cell with an effective amount of an agent, wherein said agent disrupts the coordination complex formed at the C-terminus of fungal dicer between an anion and the amino acids corresponding to the amino acids C1275, H1312, C1350 and C1352 of Dcr1 of S. pombe.
    Type: Application
    Filed: November 14, 2011
    Publication date: April 3, 2014
    Inventors: Marc Buehler, Stephan Emmerth, Frederic Hai-Trieu Allain, Pierre Barraud