Patents by Inventor Marc Ceusters

Marc Ceusters has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6194386
    Abstract: The invention relates to a labelled peptide compound, wherein the peptide has a selective neurotensin receptor affinity and is represented by the general formula R1—(1Pro)n—2Xaa—3Xbb—4Xcc—5Xdd—6Xee—7Leu—OH(SEQ ID NO.2)  (I) wherein: R1 is a (C1-C3)alkanoyl group, an arylcarbonyl group, an aryl-(C1-C3)alkanoyl group, or a chelating group attached by an amide bond or through a spacing group to the peptide molecule; Xaa and Xbb are each individually Arg or Lys; Xcc is an unsubstituted or substituted cyclic amino acid, preferably selected from Pro and Hyp; Xdd is Tyr, Trp or Phe; Xee is Leu, Ile or t.
    Type: Grant
    Filed: June 16, 1999
    Date of Patent: February 27, 2001
    Assignee: Mallinckrodt Inc.
    Inventors: John Mertens, Dirk Tourwe, Marc Ceusters
  • Patent number: 5952464
    Abstract: The invention relates to a labelled peptide compound, wherein the peptide has a selective neurotensin receptor affinity and is represented by the general formulaR.sub.1 -(.sup.1 Pro).sub.n -.sup.2 Xaa-.sup.3 Xbb-.sup.4 Xcc-.sup.5 Xdd-.sup.6 Xee-.sup.7 Leu-OH (SEQ ID NO:2) (I)wherein:R.sub.1 is a (C.sub.1 -C.sub.3)alkanoyl group, an arylcarbonyl group, an aryl-(C.sub.1 -C.sub.3)alkanoyl group, or a chelating group attached by an amide bond or through a spacing group to the peptide molecule;Xaa and Xbb are each individually Arg or Lys;Xcc is an unsubstituted or substituted cyclic amino acid, preferably selected from Pro and Hyp;Xdd is Tyr, Trp or Phe;Xee is Leu, Ile or t.-butylalanine; andn is 0 or 1;and wherein said peptide is labelled with (a) a metal isotope, or (b) with a radioactive halogen isotope; on the understanding that:(i) if the label is a metal isotope, R.sub.
    Type: Grant
    Filed: July 21, 1997
    Date of Patent: September 14, 1999
    Assignee: Mallinckrodt Inc.
    Inventors: John Mertens, Dirk Tourwe, Marc Ceusters