Patents by Inventor Marc Courchesne

Marc Courchesne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C-21-keto lupane derivatives preparation and use thereof
    Patent number: 8431556
    Abstract: The invention relates to 21-keto triterpene compounds of formula (I): wherein R1, X and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, the invention also relates to methods for prevention or treatment of HIV infections by administering therapeutically effective amounts of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof to a subject in need of such treatment.
    Type: Grant
    Filed: July 3, 2010
    Date of Patent: April 30, 2013
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Christophe Moinet, Marc Courchesne, Liliane Halab, Nathalie Chauret, Laval Chan Chun Kong
  • Lupane derivatives useful for treating HIV
    Patent number: 8269026
    Abstract: The invention relates to 21-keto triterpene compounds of formula (I): wherein R1, X, and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, the invention also relates to methods for prevention or treatment of HIV infections by administering therapeutically effective amounts of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof to a subject in need of such treatment.
    Type: Grant
    Filed: July 3, 2010
    Date of Patent: September 18, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Christophe Moinet, Liliane Halab, Nathalie Turcotte, Monica Bubenik, Marc Courchesne, Carl Poisson, Oswy Z. Pereira, Paul Nguyen-Ba, Bingcan Liu, Nathalie Chauret, Caroline Cadilhac, Laval Chan Chun Kong
  • Spirotropane compounds
    Patent number: 8124613
    Abstract: Compounds according to formula (I): wherein R1, R2, R3, n and X are defined as defined herein, and the pharmaceutically acceptable salts, hydrates and solvates thereof, are useful for the modulation of CCR5 chemokine receptor activity. Additionally, compounds according to Formula III: wherein Z, R?1, and R?2 are defined as defined herein, and the pharmaceutically acceptable salts, hydrates and solvates thereof, are useful as intermediates for production of compounds that modulate CCR5 chemokine receptor activity.
    Type: Grant
    Filed: June 14, 2007
    Date of Patent: February 28, 2012
    Assignee: Virochem Pharma Inc.
    Inventors: Christophe Moinet, Charles Blais, Monica Bubenik, Laval Chan Chun Kong, Marc Courchesne, Oswy Z. Pereira, Réal Denis, Louis Vaillancourt, Constantin G. Yannopoulos
  • Spirotropane compounds and methods for the modulation of chemokine receptor activity
    Patent number: 8076349
    Abstract: Compounds according to formula (I): wherein A, R1 and R2 are as defined herein, and the pharmaceutically acceptable salts, hydrates and solvates thereof are useful for the modulation of CCR5 chemokine receptor activity.
    Type: Grant
    Filed: December 9, 2005
    Date of Patent: December 13, 2011
    Assignee: Virochem Pharma Inc.
    Inventors: Laval Chan Chun Kong, Christophe Moinet, Marc Courchesne, Louis Vaillancourt, Monica Bubenik
  • Spirotropane compounds and methods for the modulation of chemokine receptor activity
    Patent number: 7960403
    Abstract: Compounds according to formula (I): wherein A, R1, R2 and R3 are defined as defined herein, and the pharmaceutically acceptable salts, hydrates and solvates thereof, are useful for the modulation of CCR5 chemokine receptor activity.
    Type: Grant
    Filed: December 9, 2005
    Date of Patent: June 14, 2011
    Assignee: Virochem Pharma Inc.
    Inventors: Laval Chan Chun Kong, Christophe Moinet, Marc Courchesne, Louis Vaillancourt, Charles Blais, Monica Bubenik
  • SPIROTROPANE COMPOUNDS
    Publication number: 20110105546
    Abstract: Compounds according to formula (I): wherein R1, R2, R3, n and X are defined as defined herein, and the pharmaceutically acceptable salts, hydrates and solvates thereof, are useful for the modulation of CCR5 chemokine receptor activity. Additionally, compounds according to Formula III: wherein Z, R?1, and R?2 are defined as defined herein, and the pharmaceutically acceptable salts, hydrates and solvates thereof, are useful as intermediates for production of compounds that modulate CCR5 chemokine receptor activity.
    Type: Application
    Filed: June 14, 2007
    Publication date: May 5, 2011
    Inventors: Christophe Moinet, Charles Blas, Monica Bubenik, Laval Chan Chun Kong, Marc Courchesne, Oswy Pereira, Réal Denis, Louis Vaillancourt, Constantin Yannopoulos
  • NOVEL C-21-KETO LUPANE DERIVATIVES PREPARATION AND USE THEREOF
    Publication number: 20110077228
    Abstract: The invention relates to 21-keto triterpene compounds of formula (I): wherein R1, X and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, the invention also relates to methods for prevention or treatment of HIV infections by administering therapeutically effective amounts of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof to a subject in need of such treatment.
    Type: Application
    Filed: July 3, 2010
    Publication date: March 31, 2011
    Inventors: Christophe Moinet, Marc Courchesne, Lilliane Halab, Nathalie Chauret, Laval Chan Chun Kong
  • NOVEL LUPANE DERIVATIVES
    Publication number: 20110077227
    Abstract: The invention relates to 21-keto triterpene compounds of formula (I): wherein R1, X, and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, the invention also relates to methods for prevention or treatment of HIV infections by administering therapeutically effective amounts of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof to a subject in need of such treatment.
    Type: Application
    Filed: July 3, 2010
    Publication date: March 31, 2011
    Inventors: Christophe Moinet, Liliane Halab, Nathalie Turcotte, Monica Bubenik, Marc Courchesne, Carl Poisson, Oswy Z. Pereira, Paul Nguyen-Ba, Bingcan Liu, Nathalie Chauret, Caroline Cadilhac, Laval Chan Chun Kong
  • Novel Spirotropane Compounds And Methods For The Modulation Of Chemokine Receptor Activity
    Publication number: 20090047238
    Abstract: Compounds according to formula, (I): wherein A, R1 and R2 are as defined herein, and the pharmaceutically acceptable salts, hydrates and solvates thereof are useful for the modulation of CCR5 chemokine receptor activity.
    Type: Application
    Filed: December 9, 2005
    Publication date: February 19, 2009
    Inventors: Laval Chan Chun Kong, Christophe Moinet, Marc Courchesne, Louis Vaillancourt, Monica Bubenik
  • Novel Spirotropane Compounds and Methods for the Modulation of Chemokine Receptor Activity
    Publication number: 20080267906
    Abstract: Compounds according to formula (I): wherein A, R1, R2 and R3 are defined as defined herein, and the pharmaceutically acceptable salts, hydrates and solvates thereof, are useful for the modulation of CCR5 chemokine receptor activity.
    Type: Application
    Filed: December 9, 2005
    Publication date: October 30, 2008
    Inventors: Laval Chan Chun Kong, Christophe Moinet, Marc Courchesne, Louis Vaillancourt, Charles Blais, Monica Bubenik
  • Spirohydantoin compounds and methods for the modulation of chemokine receptor activity
    Patent number: 7351713
    Abstract: Compounds of formula I wherein R1, R2, R3, R4 and R5 are as defined herein, or pharmaceutically acceptable salts, hydrates or solvates thereof, are useful for the modulation of CCR5 chemokine receptor activity.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: April 1, 2008
    Assignee: Viro Chem Pharma, Inc.
    Inventors: Laval Chan Chun Kong, Ming-Qiang Zhang, Christophe Moinet, Marc Courchesne, Thumkunta Jagadeeswar Reddy, Melanie Proulx
  • Spiro compounds and methods for the modulation of chemokine receptor activity
    Patent number: 7288548
    Abstract: Compounds of formula I wherein X, Y, Z, W, R1 and R2 as defined herein, or pharmaceutically acceptable salts, hydrates or solvates thereof, are useful for the modulation of CCR5 chemokine receptor activity.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: October 30, 2007
    Assignee: ViroChem Pharma, Inc.
    Inventors: Laval Chan Chun Kong, Ming-Qiang Zhang, Christophe Moinet, Marc Courchesne, Thumkunta Jagadeeswar Reddy
  • Thiophene and furan 2,5-dicarboxamides useful in the treatment of cancer
    Patent number: 6960594
    Abstract: A novel compound which inhibits certain integrins, particularly ?v integrins. Additionally, the novel compound may be used in a method of treating tumors or cancer which comprises administering a pharmaceutically effective amount of the compound to a patient. Additionally, the novel compound may be used in a method of inhibiting angiogensis. Finally, a method of producing the novel compound is disclosed.
    Type: Grant
    Filed: January 16, 2002
    Date of Patent: November 1, 2005
    Assignee: Shire BioChem Inc.
    Inventors: Denis Labrecque, Serge Lamothe, Marc Courchesne, Laval Chan, Giorgio Attardo, Karen Meerovitch
  • Spiro compounds and methods for the modulation of chemokine receptor activity
    Publication number: 20050075326
    Abstract: Novel compounds represented by formula I: wherein Y, Z, X, W, R1, R2 and R3 are as defined herein, or pharmaceutically acceptable salts, hydrates or solvates thereof, are useful for the modulation of CCR5 chemokine receptor activity and the treatment or prevention of diseases associated therewith.
    Type: Application
    Filed: July 19, 2004
    Publication date: April 7, 2005
    Inventors: Laval Chan Chun Kong, Ming Zhang, Christophe Moinet, Melanie Proulx, Thumkunta Reddy, Marc Courchesne
  • Spirohydantoin compounds and methods for the modulation of chemokine receptor activity
    Publication number: 20050075360
    Abstract: Compounds of formula I wherein R1, R2, R3, R4 and R5 are as defined herein, or pharmaceutically acceptable salts, hydrates or solvates thereof, are useful for the modulation of CCR5 chemokine receptor activity.
    Type: Application
    Filed: September 10, 2004
    Publication date: April 7, 2005
    Inventors: Laval Chan Chun Kong, Ming-Qiang Zhang, Christophe Moinet, Marc Courchesne, Thumkunta Reddy, Melanie Proulx
  • Spiro compounds and methods for the modulation of chemokine receptor activity
    Publication number: 20050070563
    Abstract: Compounds of formula I wherein X, Y, Z, W, R1 and R2 as defined herein, or pharmaceutically acceptable salts, hydrates or solvates thereof, are useful for the modulation of CCR5 chemokine receptor activity.
    Type: Application
    Filed: September 10, 2004
    Publication date: March 31, 2005
    Inventors: Laval Kong, Ming-Qiang Zhang, Christophe Moinet, Marc Courchesne, Thumkunta Reddy
  • Quinolizinones as integrin inhibitors
    Patent number: 6630488
    Abstract: The present invention is directed towards novel compounds that are effective inhibitors of integrins, particularly &agr;IIb&bgr;3 or &agr;v integrins such as &agr;v&bgr;3 and &agr;v&bgr;5. One embodiment of the present invention comprises a compound of formula (I) or formula (II) or a pharmaceutically acceptable salt, solvate, or metabolic precursor thereof. R1, R2, R3, and R4 are defined herein.
    Type: Grant
    Filed: March 20, 2001
    Date of Patent: October 7, 2003
    Assignee: Biochem Pharma, Inc.
    Inventors: Serge Lamothe, Boulos Zacharie, Giorgio Attardo, Denis Labrecque, Marc Courchesne, Guy Falardeau, Rabindra Rej, Shaun Abbott
  • Thiophene and furan 2,5-dicarboxamides useful in the treatment of cancer
    Publication number: 20020137947
    Abstract: A novel compound which inhibits certain integrins, particularly &agr;v integrins. Additionally, the novel compound may be used in a method of treating tumors or cancer which comprises administering a pharmaceutically effective amount of the compound to a patient. Additionally, the novel compound may be used in a method of inhibiting angiogensis. Finally, a method of producing the novel compound is disclosed.
    Type: Application
    Filed: January 16, 2002
    Publication date: September 26, 2002
    Applicant: BioChem Pharma Inc.
    Inventors: Denis Labrecque, Serge Lamothe, Marc Courchesne, Laval Chan, Giorgio Attardo, Karen Meerovitch
  • Antineoplastic heteronapthoquinones
    Patent number: 5736523
    Abstract: This invention relates to a naphthoquinone derivatives, to processes and to intermediates for preparing these derivatives, to pharmaceutical composition and to the use of these derivatives as antitumor agents in mammals.
    Type: Grant
    Filed: March 10, 1995
    Date of Patent: April 7, 1998
    Assignee: Biochem Pharma Inc.
    Inventors: Giorgio Attardo, Tibor Breining, Marc Courchesne, Serge Lamothe, Jean-Fran.cedilla.ois Lavallee, Dieu Nguyen, Rabindra Rej, Yves St-Denis, Wuyi Wang, Yao-Chang Xu, France Barbeau, Elaine Lebeau, Jean Louis Kraus
  • Processes antineoplastic heteronaphthoquinones
    Patent number: 5606037
    Abstract: This invention relates to a naphthoquinone derivatives, to processes and to intermediates for preparing these derivatives, to pharmaceutical composition and to the use of these derivatives as antitumor agents in mammals.
    Type: Grant
    Filed: March 10, 1995
    Date of Patent: February 25, 1997
    Assignee: BioChem Pharma Inc.
    Inventors: Giorgio Attardo, Tibor Breining, Marc Courchesne, Serge Lamothe, Jean-Fran.cedilla.ois Lavall ee, Dieu Nguyen, Rabindra Rej, Yves St-Denis, Wuyi Wang, Yao-Chang Xu, France Barbeau, Elaine Lebeau, Jean L. Kraus