Abstract: The present invention relates to compounds of formula (I): for use as peripheral NMDA receptor antagonists.

Abstract: This invention relates to compounds of formula (X) and salts, solvates, tautomers, N-oxides, stereoisomers, polymorphs and/or prodrugs thereof. Also disclosed is the use of the compounds of formula (X) to treat necroptosis and/or inhibit and/or degrade MLKL.

Abstract: This invention relates to compounds of formula (X) and salts, solvates, tautomers, N-oxides, stereoisomers, polymorphs and/or prodrugs thereof. Also disclosed is the use of the compounds of formula (X) to treat necroptosis, and/or inhibit and/or degrade MLKL.

Abstract: This invention relates to compounds of formula (I) and salts, solvates, tautomers, N-oxides, stereoisomers, polymorphs and/or prodrugs thereof. Also disclosed is the use of the compounds of formula (I) to treat necroptosis and/or inhibit MLKL.

Abstract: Manufacturing processes are disclosed for assembling traction battery packs that include battery systems, such as cell-to-pack battery systems. An exemplary assembly method includes inserting one or more cell stacks of the cell-to-pack battery system into a cell-compressing opening of an enclosure tray. The method may involve the use of slider plates that provide sliding surfaces that facilitate the insertion of the cell stacks into the cell compressing opening.

Abstract: A battery charging cabinet for micromobility transit vehicle batteries may include a cabinet housing, at least one drawer, a plurality of charging docks, and a plurality of battery chargers. The drawer may be configured to extend from and retract into the cabinet housing. The plurality of charging docks may be disposed in the drawer where each of the plurality of charging docks may be configured to interface with a battery for a micromobility transit vehicle. The plurality of battery chargers may be disposed in a corresponding charging dock of the drawer, where the battery charger is able to charge the battery held in the corresponding charging dock. Related systems and methods are additionally disclosed.

Abstract: A fastening device for a cleaning device by introducing pressure waves through a hollow nozzle into a boiler to be cleaned through an opening in the boiler wall has a housing body, which can be fastened to the boiler wall with the aid of a fastening flange on the boiler side, the hollow nozzle being concentric with the opening in the boiler wall and orthogonal to the boiler axis. Damping units are arranged at regular angular intervals around the hollow nozzle in the longitudinal direction thereof and are each fastened with one free end to the boiler-side fastening flange and with the respective other free end to the housing body. When the pressure waves are triggered, the housing body is resiliently retained in the longitudinal direction away from the boiler and brought back into the initial position.

Abstract: A docking station for micromobility transit vehicles is provided. The docking station may include a rack configured to dock a micromobility transit vehicle, a bollard for securing the micromobility transit vehicle within the rack, and a dock module configured to detect a characteristic of a lock cable securing the micromobility transit vehicle to the bollard. The dock module may include an inductive coil assembly disposed around a hole of the bollard to detect the lock cable inserted into the hole.

Abstract: An apparatus, system and method for providing a consumable level monitor for association with a solid content-filled consumable. The embodiments may include a sensing module embedded in a label associated with the consumable suitable to sense the consumable level; and a visual indicator suitable to receive the consumable level from the sensing module, and for communicating the consumable level to a user.

Abstract: The specification provides an improved media formulation to enhance the viability of chondrocytes in stored biological samples. The formulation includes Dulbecco's Modified Eagle Medium (DMEM), doxycycline, and hyaluronic acid, in concentrations sufficient to maintain the chondrocytes' viability significantly longer than DMEM alone. This formulation allows biological samples containing chondrocytes to retain high viability rates for extended periods to be suitable for transplant purposes, such as in osteochondral tissue transplantation.

Abstract: A gas turbine of an aircraft includes start-up system configured to drive a shaft of the gas turbine in rotation. The start-up system includes a control system and a brushless asynchronous electric machine and is supplied with a DC voltage. A method for starting the gas turbine includes the steps of converting the DC voltage into a three-phase voltage control system based on a first value representative of a rotational speed of a rotor of the electric machine and on a second value representative of a ratio of a determined target torque of the electric machine, suitable for driving the rotation of a shaft of the gas turbine at a determined speed, to the maximum theoretical torque that the electric machine is able to produce at the determined rotational speed of the rotor.

Abstract: A system and method for mitigating thermal loading between engine exhaust structures having different coefficients of thermal expansion. The engine exhaust structure comprises a metallic duct portion, a ceramic duct portion, and a double bipod fitting joining the metallic duct portion to the ceramic duct portion. The double bipod fitting is capable of flexing and taking up the thermal expansion differences between the joined metallic and ceramic ducts across the full temperature spectrum that an engine exhaust structure will experience in service.

Abstract: The invention relates to a computer implemented system and method for identification of comparables. The method may comprise: receiving input data from a plurality of data sources for a comparable, generating labeled training data for a function classifier by labeling historical search results for comparables, generating probabilistic training data for the primary product and service classifiers, training the primary product and service classifiers using the labeled training data and the probabilistic training data, determining the functions, products, services, and risks of the comparable using the corresponding classifiers, receiving attributes of a tested party, applying a scoring algorithm to calculate a similarity score for the comparable, generating a recommendation to accept the comparable, reject the comparable, or give additional scrutiny to determine acceptability, and automatically providing a written justification for the decision to accept or to reject the comparable.

Abstract: This invention relates to compounds of formula (I) and salts, solvates, tautomers, N-oxides, stereoisomers, polymorphs and/or prodrugs thereof. Also disclosed is the use of the compound of formula (I) to treat necroptosis and/or inhibit RIP1 and/or MLKL.

Abstract: This invention relates to compounds of formula (I) and salts, solvates, tautomers, N-oxides, stereoisomers, polymorphs and/or prodrugs thereof. Also disclosed is the use of the compounds of formula (I) to treat necroptosis and/or inhibit MLKL.

Abstract: A method for repairing a multi-sided structure protruding from a first surface. The method comprises mounting a retainer to the first surface, coupling a first brace connector component of a first brace to a first panel, coupling the first panel to a primary retainer connector component of the retainer, coupling a second brace connector component of the first brace to a secondary retainer connector component of the retainer, and introducing a curable material into the space between the first panel and the multi-sided structure, the first panel acting as at least a portion of a framework for containing the curable material until the curable material cures to provide a repair structure cladded, at least in part, by the first panel.

Abstract: A system and method for mitigating thermal loading between engine exhaust structures having different coefficients of thermal expansion. The engine exhaust structure comprises a metallic duct portion, a ceramic duct portion, and a double bipod fitting joining the metallic duct portion to the ceramic duct portion. The double bipod fitting is capable of flexing and taking up the thermal expansion differences between the joined metallic and ceramic ducts across the full temperature spectrum that an engine exhaust structure will experience in service.

Abstract: An auxiliary power unit, in particular for an aircraft, includes a gas generator and an electric generator. The electric generator has an input shaft that is connected to an output shaft of the gas generator. The auxiliary power unit also has an accessories housing directly connected to a rotor shaft of the electric generator, wherein the electric generator is interposed between the gas generator and the accessories housing.

Abstract: A multi-analyte sensor device is disclosed. The multi-analyte device is a handheld device that includes a replaceable sensor. In one embodiment, the replaceable sensor includes a plurality of electrodes coated with one or more different molecular imprinted polymer (MIP) coatings for measuring concentrations of target analytes. The replaceable sensor is configured to be attached or detached from the device one or more times.

Abstract: A docking station for micromobility transit vehicles is provided. The docking station may include a rack configured to dock a micromobility transit vehicle, a bollard for securing the micromobility transit vehicle within the rack, and a dock module configured to detect a characteristic of a lock cable securing the micromobility transit vehicle to the bollard. The dock module may include an inductive coil assembly disposed around a hole of the bollard to detect the lock cable inserted into the hole.