Abstract: The present invention relates to compounds of formula (I); for use as peripheral NMDA receptor antagonists.

Abstract: This invention relates to compounds of formula (I) and salts, solvates, tautomers, N-oxides, stereoisomers, polymorphs and/or prodrugs thereof. Also disclosed is the use of the compound of formula (I) to treat necroptosis and/or inhibit RIP1 and/or MLKL.

Abstract: This invention relates to compounds of formula (I) and salts, solvates, tautomers, N-oxides, stereoisomers, polymorphs and/or prodrugs thereof. Also disclosed is the use of the compounds of formula (I) to treat necroptosis and/or inhibit MLKL.

Abstract: A method for repairing a multi-sided structure protruding from a first surface. The method comprises mounting a retainer to the first surface, coupling a first brace connector component of a first brace to a first panel, coupling the first panel to a primary retainer connector component of the retainer, coupling a second brace connector component of the first brace to a secondary retainer connector component of the retainer, and introducing a curable material into the space between the first panel and the multi-sided structure, the first panel acting as at least a portion of a framework for containing the curable material until the curable material cures to provide a repair structure cladded, at least in part, by the first panel.

Abstract: A system and method for mitigating thermal loading between engine exhaust structures having different coefficients of thermal expansion. The engine exhaust structure comprises a metallic duct portion, a ceramic duct portion, and a double bipod fitting joining the metallic duct portion to the ceramic duct portion. The double bipod fitting is capable of flexing and taking up the thermal expansion differences between the joined metallic and ceramic ducts across the full temperature spectrum that an engine exhaust structure will experience in service.

Abstract: An auxiliary power unit, in particular for an aircraft, includes a gas generator and an electric generator. The electric generator has an input shaft that is connected to an output shaft of the gas generator. The auxiliary power unit also has an accessories housing directly connected to a rotor shaft of the electric generator, wherein the electric generator is interposed between the gas generator and the accessories housing.

Abstract: A multi-analyte sensor device is disclosed. The multi-analyte device is a handheld device that includes a replaceable sensor. In one embodiment, the replaceable sensor includes a plurality of electrodes coated with one or more different molecular imprinted polymer (MIP) coatings for measuring concentrations of target analytes. The replaceable sensor is configured to be attached or detached from the device one or more times.

Abstract: A docking station for micromobility transit vehicles is provided. The docking station may include a rack configured to dock a micromobility transit vehicle, a bollard for securing the micromobility transit vehicle within the rack, and a dock module configured to detect a characteristic of a lock cable securing the micromobility transit vehicle to the bollard. The dock module may include an inductive coil assembly disposed around a hole of the bollard to detect the lock cable inserted into the hole.

Abstract: A multi-analyte sensor includes a body having a proximal end and a distal end. A plurality of strips is connected to one end of the body and a plurality of electrical conductors run through the body and into the plurality of strips. Exposed portions of first and second electrical conductors running through first and second strips are coated with analyte-responsive materials, such as a first molecular imprinted polymer (MIP) and a second MIP, respectively. The first MIP has binding sites for a first target analyte and the second MIP has binding sites for a second target analyte. The multi-analyte sensor may be part of a sensing device that also includes a controller and a data store.

Abstract: A multi-analyte sensor includes a body having a proximal end and a distal end. A plurality of strips is connected to one end of the body and a plurality of electrical conductors run through the body and into the plurality of strips. Exposed portions of first and second electrical conductors running through first and second strips are coated with analyte-responsive materials, such as a first molecular imprinted polymer (MIP) and a second MIP, respectively. The first MIP has binding sites for a first target analyte and the second MIP has binding sites for a second target analyte. The multi-analyte sensor may be part of a sensing device that also includes a controller and a data store.

Abstract: A battery charging cabinet for micromobility transit vehicle batteries may include a cabinet housing, at least one drawer, a plurality of charging docks, and a plurality of battery chargers. The drawer may be configured to extend from and retract into the cabinet housing. The plurality of charging docks may be disposed in the drawer where each of the plurality of charging docks may be configured to interface with a battery for a micromobility transit vehicle. The plurality of battery chargers may be disposed in a corresponding charging dock of the drawer, where the battery charger is able to charge the battery held in the corresponding charging dock. Related systems and methods are additionally disclosed.

Abstract: A method for repairing a multi-sided structure protruding from a first surface. The method comprises mounting a retainer to the first surface, coupling a first brace connector component of a first brace to a first panel, coupling the first panel to a primary retainer connector component of the retainer, coupling a second brace connector component of the first brace to a secondary retainer connector component of the retainer, and introducing a curable material into the space between the first panel and the multi-sided structure, the first panel acting as at least a portion of a framework for containing the curable material until the curable material cures to provide a repair structure cladded, at least in part, by the first panel.

Abstract: A valve for free-flowing media, such as a glue valve, with a valve housing, and with a closure member, such as a valve tappet, which is movable in the valve housing by means of an electromagnet and which bears with a closure piece on a valve seat in the closed position of the valve and which sits at least partially in a continuous interior of a one-piece coil carrier on which the windings of a coil of the electromagnet are wound, and having two terminal receivers for a dosing unit and a valve lift adjustment unit with an elongate abutment part which is arranged at least in part in the interior of the coil carrier and which limits a movement of the closure member in the direction of the valve lift adjustment unit, with the valve lift adjustment unit being is secured on the coil carrier.

Abstract: A neural implant is provided for electrical stimulation and recording of brain or nervous system tissue. The neural implant is of cellular scale and could be used as a natural integration in neural tissue that enables the development of scalable brain machine interfaces that stably interface with the same neural populations over a life-time period. A biomimetic a multi-channel neural implant is provided sharing similar dimensions, dynamics, and spatial distribution as that of natural axon bundles in the brain. A simple approach of delivery compatible with commercially available electrophysiology rigs enabled minimal surgical perturbation of existing neural architectures. This invention represents a step forward in developing the next generation of seamless brain-machine interface to study and modulate the activities of specific sub-populations of neurons, and to develop therapies for a plethora of neurological diseases.

Abstract: Systems, methods and apparatus for injecting a solid chemical for inhibiting, decreasing or preventing precipitation and/or deposition of foulants and/or contaminants in oilfield tubulars. The use of solid chemicals or highly viscous fluids providing ease of shipment, greater economy in storage, shipment and delivery and increased ease of use.

Abstract: Systems, methods and apparatus for injecting a diluted solid chemical, a diluted highly viscous fluid, or a diluted fluidified solid for inhibiting, decreasing or preventing precipitation and/or deposition of foulants and/or contaminants in oilfield tubulars. The use of solid chemicals or highly viscous fluids providing ease of shipment, greater economy in storage, shipment and delivery and increased ease of use.

Abstract: A valve for free-flowing media, such as a glue valve, with a valve housing, and with a closure member, such as a valve tappet, which is movable in the valve housing by means of an electromagnet and which bears with a closure piece on a valve seat in the closed position of the valve and which sits at least partially in a continuous interior of a one-piece coil carrier on which the windings of a coil of the electromagnet are wound, and having two terminal receivers for a dosing unit and a valve lift adjustment unit with an elongate abutment part which is arranged at least in part in the interior of the coil carrier and which limits a movement of the closure member in the direction of the valve lift adjustment unit, with the valve lift adjustment unit being is secured on the coil carrier.

Abstract: A valve for free-flowing media, in particular a glue valve, with a valve housing, and with a closure member, in particular a valve tappet, which is movable in the valve housing by means of an electromagnet and which bears with a closure piece on a valve seat in the closed position of the valve and which sits at least partially in an in particular continuous interior of a preferably one-piece coil carrier on which the windings of a coil of the electromagnet are wound, and with a valve lift adjustment unit with an elongate abutment part which is arranged at least in part in the interior of the coil carrier and which limits a movement of the closure member in the direction of the valve lift adjustment unit, with the valve lift adjustment unit being is secured on the coil carrier.

Abstract: Various embodiments provide a network planning tool comprising one or more memory storage areas containing data related to a plurality of transportation networks, and one or more computer processors configured to: receive input data comprising one or more modifications to one or more parameters associated with the plurality of transportation networks; retrieve at least a portion of the data contained in the one or more memory storage areas; validate the input data against the portion of data retrieved from the one or more memory storage areas, the validating comprising at least calculating one or more impacts to the integrated flow model based at least in part upon the received input data; and calculate, based at least in part upon the identified one or more impacts, one or more updated flow models for the plurality of transportation networks. Associated computer program products and computer-implemented methods are also provided.