Patents by Inventor Marc Doubleday

Marc Doubleday has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200063184
    Abstract: In some embodiments, the invention provides methods for detecting and/or classifying an anticoagulant at a therapeutically relevant amount or higher in a patient, including subjecting a sample of a control blood component (known not to contain the anticoagulant) to a clotting assay in the presence of a Factor Xa reagent to obtain a control clotting measurement; and subjecting a sample of a blood component from a patient suspected of having the anticoagulant to the clotting assay in the presence of the Factor Xa reagent to obtain a patient clotting measurement, wherein the patient clotting measurement sample greater than the control clotting measurement indicates the presence of the anticoagulant at a therapeutically relevant amount or higher in the patient. In some embodiments, the invention includes methods for classifying an anticoagulant as an anti-Factor Xa or a direct thrombin inhibitor anticoagulant using a clotting assay in the presence of an ecarin reagent.
    Type: Application
    Filed: November 5, 2019
    Publication date: February 27, 2020
    Inventors: Fowzia S. Zaman, Marc Doubleday
  • Patent number: 10501773
    Abstract: In some embodiments, the invention provides methods for detecting and/or classifying an anticoagulant at a therapeutically relevant amount or higher in a patient, including subjecting a sample of a control blood component (known not to contain the anticoagulant) to a clotting assay in the presence of a Factor Xa reagent to obtain a control clotting measurement; and subjecting a sample of a blood component from a patient suspected of having the anticoagulant to the clotting assay in the presence of the Factor Xa reagent to obtain a patient clotting measurement, wherein the patient clotting measurement sample greater than the control clotting measurement indicates the presence of the anticoagulant at a therapeutically relevant amount or higher in the patient. In some embodiments, the invention includes methods for classifying an anticoagulant as an anti-Factor Xa or a direct thrombin inhibitor anticoagulant using a clotting assay in the presence of an ecarin reagent.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: December 10, 2019
    Assignee: Haemonetics Corporation
    Inventors: Fowzia S. Zaman, Marc Doubleday
  • Publication number: 20170355961
    Abstract: Solutions and suspensions comprising polymerized hemoglobin derived from human blood are disclosed. The solutions and suspensions may comprise cell culture medium, an enzyme (such as a protease), and/or a buffer. Processes of preparing the solutions and suspensions are also disclosed. The solutions and suspensions may be employed in methods of isolating mammalian cells, such as pancreatic islets, methods of preserving mammalian tissue and organs, methods of aiding the recovery of mammalian cells following their isolation, methods of maintaining mammalian cells, methods of propagating mammalian cells, and methods of treating a mammal with diabetes.
    Type: Application
    Filed: May 23, 2017
    Publication date: December 14, 2017
    Inventors: Jose Oberholzer, Marc Doubleday
  • Patent number: 9657271
    Abstract: Solutions and suspensions comprising polymerized hemoglobin derived from human blood are disclosed. The solutions and suspensions may comprise cell culture medium, an enzyme (such as a protease), and/or a buffer. Processes of preparing the solutions and suspensions are also disclosed. The solutions and suspensions may be employed in methods of isolating mammalian cells, such as pancreatic islets, methods of preserving mammalian tissue and organs, methods of aiding the recovery of mammalian cells following their isolation, methods of maintaining mammalian cells, methods of propagating mammalian cells, and methods of treating a mammal with diabetes.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: May 23, 2017
    Assignees: The Board of Trustees of the University of Illinois, Hemoglobin Oxygen Therapeutics LLC
    Inventors: Jose Oberholzer, Marc Doubleday
  • Publication number: 20160032355
    Abstract: In some embodiments, the invention provides methods for detecting and/or classifying an anticoagulant at a therapeutically relevant amount or higher in a patient, including subjecting a sample of a control blood component (known not to contain the anticoagulant) to a clotting assay in the presence of a Factor Xa reagent to obtain a control clotting measurement; and subjecting a sample of a blood component from a patient suspected of having the anticoagulant to the clotting assay in the presence of the Factor Xa reagent to obtain a patient clotting measurement, wherein the patient clotting measurement sample greater than the control clotting measurement indicates the presence of the anticoagulant at a therapeutically relevant amount or higher in the patient. In some embodiments, the invention includes methods for classifying an anticoagulant as an anti-Factor Xa or a direct thrombin inhibitor anticoagulant using a clotting assay in the presence of an ecarin reagent.
    Type: Application
    Filed: July 30, 2015
    Publication date: February 4, 2016
    Inventors: Fowzia S. Zaman, Marc Doubleday
  • Publication number: 20110200981
    Abstract: Solutions and suspensions comprising polymerized hemoglobin derived from human blood are disclosed. The solutions and suspensions may comprise cell culture medium, an enzyme (such as a protease), and/or a buffer. Processes of preparing the solutions and suspensions are also disclosed. The solutions and suspensions may be employed in methods of isolating mammalian cells, such as pancreatic islets, methods of preserving mammalian tissue and organs, methods of aiding the recovery of mammalian cells following their isolation, methods of maintaining mammalian cells, methods of propagating mammalian cells, and methods of treating a mammal with diabetes.
    Type: Application
    Filed: March 7, 2011
    Publication date: August 18, 2011
    Applicant: OPK Biotech LLC
    Inventor: Marc Doubleday
  • Patent number: 7435795
    Abstract: A hemoglobin solution packaged in a flexible oxygen-impermeable container system. The container system includes a multi-layer film having at least a product contact layer, an oxygen and moisture barrier layer and an exterior layer. The flexible container system further includes an interface port for filling the flexible container with the hemoglobin solution and delivering the hemoglobin solution. The hemoglobin solution comprises a substantially stroma and tetramer free, cross linked, pyridoxylated hemoglobin solution including preservatives such as ascorbic acid, glycine and dextrose.
    Type: Grant
    Filed: February 23, 2007
    Date of Patent: October 14, 2008
    Assignee: Northfield Laboratories, Inc.
    Inventors: Robert McGinnis, Gabriel Chavez, Marc Doubleday, Richard DeWoskin, Anthony Avella
  • Patent number: 7411044
    Abstract: A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer to tetramer and removing tetramer from the hemoglobin solution.
    Type: Grant
    Filed: August 24, 2006
    Date of Patent: August 12, 2008
    Assignee: Northfield Laboratories, Inc.
    Inventors: Anthony Avella, Richard DeWoskin, Marc Doubleday
  • Publication number: 20080108555
    Abstract: A process is disclosed for the preparation of an essentially tetramer-free, substantially stroma-free, polymerized, pyridoxylated hemoglobin. Also disclosed is an essentially tetramer-free, substantially stroma-free, polymerized, pyridoxylated hemoglobin product capable of being infused into human patients in an amount of up to about 5 liters.
    Type: Application
    Filed: January 10, 2008
    Publication date: May 8, 2008
    Inventors: Richard DeWoskin, Marc Doubleday
  • Patent number: 7291592
    Abstract: Methods for treating a mammal suffering from massive blood loss comprising administering to the mammal a polymerized hemoglobin solution.
    Type: Grant
    Filed: October 3, 2003
    Date of Patent: November 6, 2007
    Assignee: Northfield Laboratories, Inc.
    Inventors: Steven Gould, Richard DeWoskin, Marc Doubleday, George Hides
  • Publication number: 20070196810
    Abstract: Solutions and suspensions comprising polymerized hemoglobin derived from human blood are disclosed. The solutions and suspensions may comprise cell culture medium, an enzyme (such as a protease), and/or a buffer. Processes of preparing the solutions and suspensions are also disclosed. The solutions and suspensions may be employed in methods of isolating mammalian cells, such as pancreatic islets, methods of preserving mammalian tissue and organs, methods of aiding the recovery of mammalian cells following their isolation, methods of maintaining mammalian cells, methods of propagating mammalian cells, and methods of treating a mammal with diabetes.
    Type: Application
    Filed: January 24, 2007
    Publication date: August 23, 2007
    Inventor: Marc Doubleday
  • Publication number: 20070173435
    Abstract: A hemoglobin solution packaged in a flexible oxygen-impermeable container system. The container system includes a multi-layer film having at least a product contact layer, an oxygen and moisture barrier layer and an exterior layer. The flexible container system further includes an interface port for filling the flexible container with the hemoglobin solution and delivering the hemoglobin solution. The hemoglobin solution comprises a substantially stroma and tetramer free, cross linked, pyridoxylated hemoglobin solution including preservatives such as ascorbic acid, glycine and dextrose.
    Type: Application
    Filed: February 23, 2007
    Publication date: July 26, 2007
    Applicant: Northfield Laboratories, Inc.
    Inventors: Robert McGinnis, Gabriel Chavez, Marc Doubleday, Richard DeWoskin, Anthony Avella
  • Patent number: 7202341
    Abstract: A hemoglobin solution packaged in a flexible oxygen-impermeable container system. The container system includes a multi-layer film having at least a product contact layer, an oxygen and moisture barrier layer and an exterior layer. The flexible container system further includes an interface port for filling the flexible container with the hemoglobin solution and delivering the hemoglobin solution. The hemoglobin solution comprises a substantially stroma and tetramer free, cross linked, pyridoxylated hemoglobin solution including preservatives such as ascorbic acid, glycine and dextrose.
    Type: Grant
    Filed: September 21, 2005
    Date of Patent: April 10, 2007
    Assignee: Northfield Laboratories, Inc.
    Inventors: Robert McGinnis, Gabriel Chavez, Marc Doubleday, Richard DeWoskin, Anthony Avella
  • Publication number: 20060287222
    Abstract: A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer to tetramer and removing tetramer from the hemoglobin solution.
    Type: Application
    Filed: August 24, 2006
    Publication date: December 21, 2006
    Applicant: Northfield Laboratories, Inc.
    Inventors: Anthony Avella, Richard DeWoskin, Marc Doubleday
  • Patent number: 7135553
    Abstract: A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer to tetramer and removing tetramer from the hemoglobin solution.
    Type: Grant
    Filed: January 29, 2004
    Date of Patent: November 14, 2006
    Assignee: Northfield Laboratories, Inc.
    Inventors: Anthony Avella, Richard DeWoskin, Marc Doubleday
  • Publication number: 20060014671
    Abstract: A hemoglobin solution packaged in a flexible oxygen-impermeable container system. The container system includes a multi-layer film having at least a product contact layer, an oxygen and moisture barrier layer and an exterior layer. The flexible container system further includes an interface port for filling the flexible container with the hemoglobin solution and delivering the hemoglobin solution. The hemoglobin solution comprises a substantially stroma and tetramer free, cross linked, pyridoxylated hemoglobin solution including preservatives such as ascorbic acid, glycine and dextrose.
    Type: Application
    Filed: September 21, 2005
    Publication date: January 19, 2006
    Applicant: Northfield Laboratories, Inc.
    Inventors: Robert McGinnis, Gabriel Chavez, Marc Doubleday, Richard DeWoskin, Anthony Avella
  • Publication number: 20050065067
    Abstract: A process is disclosed for the preparation of an essentially tetramer-free, substantially stroma-free, polymerized, pyridoxylated hemoglobin. Also disclosed is an essentially tetramer-free, substantially stroma-free, polymerized, pyridoxylated hemoglobin product capable of being infused into human patients in an amount of up to about 5 liters.
    Type: Application
    Filed: November 19, 2004
    Publication date: March 24, 2005
    Inventors: Richard DeWoskin, Marc Doubleday
  • Publication number: 20040186047
    Abstract: A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer to tetramer and removing tetramer from the hemoglobin solution.
    Type: Application
    Filed: January 29, 2004
    Publication date: September 23, 2004
    Applicant: Northfield Laboratories
    Inventors: Anthony Avella, Richard DeWoskin, Marc Doubleday
  • Publication number: 20030065149
    Abstract: A hemoglobin solution packaged in a flexible oxygen-impermeable container system. The container system includes a multi-layer film having at least a product contact layer, an oxygen and moisture barrier layer and an exterior layer. The flexible container system further includes an interface port for filling the flexible container with the hemoglobin solution and delivering the hemoglobin solution. The hemoglobin solution comprises a substantially stroma and tetramer free, cross linked, pyridoxylated hemoglobin solution including preservatives such as ascorbic acid, glycine and dextrose.
    Type: Application
    Filed: April 18, 2002
    Publication date: April 3, 2003
    Applicant: Northfield Laboratories
    Inventors: Robert McGinnis, Gabriel Chavez, Marc Doubleday, Richard DeWoskin, Anthony Avella