Abstract: Benzhydrylsulphinyl derivatives are used to prevent the sleepiness associated with pain medication. Such derivatives selectively antagonize the hypnogenic effect of anti-pain treatment, such as morphine, without affecting the analgesic activity of the treatment and without creating other disadvantages. Methods of treatment and pharmaceutical compositions are provided.

Abstract: The invention concerns the use for making medicines with waking effect in conditions of disorders affecting wakefulness related to morphine treatment of sulphinyl benzhydryl compounds of formula (I) in which: each of the cycles is substituted by one or several groups F, Cl, Br, CF3 , NO2, NH2, C1-C4 alkyl, C1-C4 alkoxy, methylenedioxy; R is —OH, H, C1-C4 alkyl C1-C4 hydroxyalkyl, or R1R2N—Y—, where Y is a hydrocarbon radical in C1-C4 with linear or branched chain; n is a whole number equal to 1, 2 or 3; and their additive salts when R comprises a basic radical. Said medicines enable to reduce sleepiness in patients without affecting the antalgic effect of morphine.