Patents by Inventor Marc F. Verhagen

Marc F. Verhagen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF ACTIVATING CLOSTRIDIAL TOXINS
    Publication number: 20150232905
    Abstract: The specification discloses modified Clostridial toxins comprising an exogenous Clostridial toxin di-chain loop protease cleavage site located within the di-chain loop region; polynucleotide molecules encoding such modified Clostridial toxins; method of producing such modified Clostridial toxins, method of activating such modified Clostridial toxins and methods of activating recombinantly-expressed Clostridial toxins.
    Type: Application
    Filed: May 4, 2015
    Publication date: August 20, 2015
    Inventors: Marc F. Verhagen, Dean G. Stathakis, Lance E. Steward
  • METHODS OF ACTIVATING CLOSTRIDIAL TOXINS
    Publication number: 20130288336
    Abstract: The specification discloses modified Clostridial toxins comprising an exogenous Clostridial toxin di-chain loop protease cleavage site located within the di-chain loop region; polynucleotide molecules encoding such modified Clostridial toxins; method of producing such modified Clostridial toxins, method of activating such modified Clostridial toxins and methods of activating recombinantly-expressed Clostridial toxins.
    Type: Application
    Filed: July 15, 2013
    Publication date: October 31, 2013
    Inventors: Marc F. Verhagen, Dean G. Stathakis, Lance E. Steward
  • METHODS OF ACTIVATING CLOSTRIDIAL TOXINS
    Publication number: 20130281666
    Abstract: The specification discloses modified Clostridial toxins comprising an exogenous Clostridial toxin di-chain loop protease cleavage site located within the di-chain loop region; polynucleotide molecules encoding such modified Clostridial toxins; method of producing such modified Clostridial toxins, method of activating such modified Clostridial toxins and methods of activating recombinantly-expressed Clostridial toxins.
    Type: Application
    Filed: April 30, 2013
    Publication date: October 24, 2013
    Inventors: Marc F. Verhagen, Dean G. Stathakis, Lance E. Steward
  • METHODS OF ACTIVATING CLOSTRIDIAL TOXINS
    Publication number: 20130245227
    Abstract: The specification discloses modified Clostridial toxins comprising an exogenous Clostridial toxin di-chain loop protease cleavage site located within the di-chain loop region; polynucleotide molecules encoding such modified Clostridial toxins; method of producing such modified Clostridial toxins, method of activating such modified Clostridial toxins and methods of activating recombinantly-expressed Clostridial toxins.
    Type: Application
    Filed: May 31, 2013
    Publication date: September 19, 2013
    Applicant: Allergan, Inc.
    Inventors: Marc F. Verhagen, Dean G. Stathakis, Lance E. Steward
  • Methods of activating clostridial toxins
    Patent number: 8486422
    Abstract: The specification discloses modified Clostridial toxins comprising an exogenous Clostridial toxin di-chain loop protease cleavage site located within the di-chain loop region; polynucleotide molecules encoding such modified Clostridial toxins; method of producing such modified Clostridial toxins, method of activating such modified Clostridial toxins and methods of activating recombinantly-expressed Clostridial toxins.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: July 16, 2013
    Inventors: Marc F. Verhagen, Dean G. Stathakis, Lance E. Steward
  • Methods of Activating Clostridial Toxins
    Publication number: 20100286371
    Abstract: The specification discloses modified Clostridial toxins comprising an exogenous Clostridial toxin di-chain loop protease cleavage site located within the di-chain loop region; polynucleotide molecules encoding such modified Clostridial toxins; method of producing such modified Clostridial toxins, method of activating such modified Clostridial toxins and methods of activating recombinantly-expressed Clostridial toxins.
    Type: Application
    Filed: June 27, 2008
    Publication date: November 11, 2010
    Inventors: Marc F. Verhagen, Dean G. Stathakis, Lance E. Steward