Abstract: A method and device for extracorporeal treatment of a patient by heating the patient's blood and/or a regional anatomic area which utilizes an optional hemodialysis machine capable of heating the fluids to 48° C., an optional parallel plate dialyzer together with a sorbent-based detoxifier, a tubular heat exchanger and a high flow positive displacement puma-in addition to various probes and catheters. The present invention also includes a disposable tubing set for directing fluids used in extracorporeal hyperthermia procedures. The tubing set contains a fluid reservoir, accommodates the positive displacement pump, and includes a heat exchanger for heating blood or fluid. The specific improvements in extracorporeal heating afforded by this system inhere in the combined high flow of the pump and the high temperature—up to 52° C.