Patents by Inventor Marc Grenley

Marc Grenley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210170052
    Abstract: An administration device comprising an array of needles, one or more fluid agents, and at least one hydrogel is described. The device can simultaneously deliver a plurality of fluid agents along respective axes into a tissue. The use of hydrogel leads to constrained delivery of the fluid agents. The constrained delivery of an agent is also achieved by depositing a drug implant into a tissue. The effect of an agent on the tissue can be evaluated thereafter. In addition, the invention is directed to treating muscle diseases by delivering a therapeutic agent in vivo, and the use of reporter tissues for candidate drug evaluation, detecting and characterizing resistance.
    Type: Application
    Filed: October 15, 2020
    Publication date: June 10, 2021
    Inventors: Richard Klinghoffer, Jason Frazier, Marc Grenley
  • Patent number: 10478157
    Abstract: Methods and devices for delivering an agent to a solid tissue in vivo for assessment of efficacy are described. One method involves withdrawing of a needle from and injecting of the agent into the solid tissue; another method involves delivering the agent using a plurality of microdialysis probes to a solid tissue.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: November 19, 2019
    Assignee: PRESAGE BIOSCIENCES, INC.
    Inventors: Jason Frazier, Richard Klinghoffer, Marc Grenley
  • Publication number: 20180256754
    Abstract: An administration device comprising an array of needles, one or more fluid agents, and at least one hydrogel is described. The device can simultaneously deliver a plurality of fluid agents along respective axes into a tissue. The use of hydrogel leads to constrained delivery of the fluid agents. The constrained delivery of an agent is also achieved by depositing a drug implant into a tissue. The effect of an agent on the tissue can be evaluated thereafter. In addition, the invention is directed to treating muscle diseases by delivering a therapeutic agent in vivo, and the use of reporter tissues for candidate drug evaluation, detecting and characterizing resistance.
    Type: Application
    Filed: November 13, 2017
    Publication date: September 13, 2018
    Inventors: Richard Klinghoffer, Jason Frazier, Marc Grenley
  • Publication number: 20170296154
    Abstract: Methods and devices for delivering an agent to a solid tissue in vivo for assessment of efficacy are described. One method involves withdrawing of a needle from and injecting of the agent into the solid tissue; another method involves delivering the agent using a plurality of microdialysis probes to a solid tissue.
    Type: Application
    Filed: November 28, 2016
    Publication date: October 19, 2017
    Inventors: Jason Frazier, Richard Klinghoffer, Marc Grenley
  • Publication number: 20140378944
    Abstract: Methods and devices for delivering an agent to a solid tissue in vivo for assessment of efficacy are described. One method involves withdrawing of a needle from and injecting of the agent into the solid tissue; another method involves delivering the agent using a plurality of microdialysis probes to a solid tissue.
    Type: Application
    Filed: July 10, 2014
    Publication date: December 25, 2014
    Inventors: Jason Frazier, Richard Klinghoffer, Marc Grenley
  • Publication number: 20140323907
    Abstract: Methods and devices for delivering an agent to a solid tissue in vivo for assessment of efficacy are described. One method involves withdrawing of a needle from and injecting of the agent into the solid tissue; another method involves delivering the agent using a plurality of microdialysis probes to a solid tissue.
    Type: Application
    Filed: October 26, 2012
    Publication date: October 30, 2014
    Inventors: Jason Frazier, Richard Hoffer, Marc Grenley
  • Publication number: 20140170072
    Abstract: An administration device comprising an array of needles, one or more fluid agents, and at least one hydrogel is described. The device can simultaneously deliver a plurality of fluid agents along respective axes into a tissue. The use of hydrogel leads to constrained delivery of the fluid agents. The constrained delivery of an agent is also achieved by depositing a drug implant into a tissue. The effect of an agent on the tissue can be evaluated thereafter. In addition, the invention is directed to treating muscle diseases by delivering a therapeutic agent in vivo, and the use of reporter tissues for candidate drug evaluation, detecting and characterizing resistance.
    Type: Application
    Filed: December 5, 2013
    Publication date: June 19, 2014
    Inventors: Richard Klinghoffer, Jason Frazier, Marc Grenley
  • Publication number: 20140155861
    Abstract: Disclosed herein are devices and methods for delivering agents to a solid tissue.
    Type: Application
    Filed: August 8, 2013
    Publication date: June 5, 2014
    Applicant: Presage Biosciences, Inc.
    Inventors: Edward Gallagher, Alicia Moreno-Gonzelez, Worm Lund, SR., Worm Lund, JR., Marc Grenley