Patents by Inventor Marc Guell

Marc Guell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genome engineering
    Patent number: 10563225
    Abstract: Methods are provided for the use of Cas9 in genome engineering of stem cells. Methods include introducing into the stem cell a first foreign nucleic acid encoding a guide RNA complementary to a target DNA and which guides a Cas9 enzyme to the target DNA, wherein the RNA and the enzyme are members of a co-localization complex for the target DNA, introducing into the stem cell a second foreign nucleic acid encoding a donor nucleic acid sequence, wherein the guide RNA and the donor nucleic acid sequences are expressed, wherein the guide RNA and the Cas 9 enzyme co-localize to the target DNA, the Cas 9 enzyme cleaves the target DNA and the donor nucleic acid is inserted into the target DNA to produce altered DNA in the stem cell.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: February 18, 2020
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Luhan Yang, Marc Guell, Joyce Lichi Yang
  • Multiplexed Genome Editing
    Publication number: 20190350177
    Abstract: A method of modulating some or all copies of a gene in a cell is provided including introducing into a cell one or more ribonucleic acid (RNA) sequences that comprise a portion that is complementary to all or a portion of each of the one or more target nucleic acid sequences, and a nucleic acid sequence that encodes a Cas protein and maintaining the cells under conditions in which the Cas protein is expressed and the Cas protein binds and modulates the one or more target nucleic acid sequences in the cell.
    Type: Application
    Filed: August 5, 2019
    Publication date: November 21, 2019
    Applicant: President and Fellows of Harvard College
    Inventors: George M. Church, Luhan Yang, Marc Guell
  • METHODS AND COMPOSITIONS FOR CHANGING THE COMPOSITION OF THE SKIN MICROBIOME USING COMPLEX MIXTURES OF BACTERIAL STRAINS
    Publication number: 20190314428
    Abstract: Aspects of the invention relate to compositions comprising two or more live bacterial strains for topical administration to the skin, wherein the two or more live bacterial strains are Propionibacterium acnes (P. acnes) bacterial strains, and methods for use.
    Type: Application
    Filed: October 19, 2017
    Publication date: October 17, 2019
    Applicant: S-Biomedic NV
    Inventors: Bernhard Pätzold, Marc Güell
  • Multiplexed genome editing
    Patent number: 10375938
    Abstract: A method of modulating some or all copies of a gene in a cell is provided including introducing into a cell one or more ribonucleic acid (RNA) sequences that comprise a portion that is complementary to all or a portion of each of the one or more target nucleic acid sequences, and a nucleic acid sequence that encodes a Cas protein and maintaining the cells under conditions in which the Cas protein is expressed and the Cas protein binds and modulates the one or more target nucleic acid sequences in the cell.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: August 13, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Luhan Yang, Marc Guell
  • Methods and Systems of Cell-Free Enzyme Discovery and Optimization
    Publication number: 20190112598
    Abstract: Methods and systems of cell-fee enzyme discovery and optimization are provided.
    Type: Application
    Filed: March 7, 2017
    Publication date: April 18, 2019
    Inventors: George M. CHURCH, Jameson K. ROGERS, Marc GUELL, Alexander GARRUSS
  • Multiplexed Genome Editing
    Publication number: 20180288983
    Abstract: A method of modulating some or all copies of a gene in a cell is provided including introducing into a cell one or more ribonucleic acid (RNA) sequences that comprise a portion that is complementary to all or a portion of each of the one or more target nucleic acid sequences, and a nucleic acid sequence that encodes a Cas protein and maintaining the cells under conditions in which the Cas protein is expressed and the Cas protein binds and modulates the one or more target nucleic acid sequences in the cell.
    Type: Application
    Filed: October 7, 2016
    Publication date: October 11, 2018
    Inventors: George M. Church, Luhan Yang, Marc Guell
  • Multiplexed Genome Editing
    Publication number: 20180171361
    Abstract: A method of modulating some or all copies of a gene in a cell is provided including introducing into a cell one or more ribonucleic acid (RNA) sequences that comprise a portion that is complementary to all or a portion of each of the one or more target nucleic acid sequences, and a nucleic acid sequence that encodes a Cas protein and maintaining the cells under conditions in which the Cas protein is expressed and the Cas protein binds and modulates the one or more target nucleic acid sequences in the cell.
    Type: Application
    Filed: February 5, 2018
    Publication date: June 21, 2018
    Inventors: George M. Church, Luhan Yang, Marc Guell
  • METHODS AND COMPOSITIONS FOR CHANGING THE COMPOSITION OF THE SKIN MICROBIOME USING COMPLEX MIXTURES OF BACTERIAL STRAINS
    Publication number: 20180142202
    Abstract: Aspects of the invention relate to compositions comprising one or more live bacterial strains for topical administration to the skin, wherein the one or more live bacterial strains are Propionibacterium acnes (P. acnes) bacterial strains, and methods for use.
    Type: Application
    Filed: April 20, 2016
    Publication date: May 24, 2018
    Applicant: S-Biomedic NV
    Inventors: Bernhard Pätzold, Marc Güell
  • Genome engineering
    Patent number: 9914939
    Abstract: Methods of genome engineering in cells using a TALEN lacking repeat sequences or Cas9 is provided.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: March 13, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Luhan Yang, Marc Guell, Joyce Lichi Yang
  • Genome Engineering
    Publication number: 20160369301
    Abstract: Methods of genome engineering in cells using a TALEN lacking repeat sequences or Cas9 is provided.
    Type: Application
    Filed: July 25, 2014
    Publication date: December 22, 2016
    Inventors: George M. Church, Luhan Yang, Marc Guell, Joyce Lichi Yang
  • Genome Engineering
    Publication number: 20150031133
    Abstract: Methods of genome engineering in cells using a TALEN lacking repeat sequences or Cas9 is provided.
    Type: Application
    Filed: June 30, 2014
    Publication date: January 29, 2015
    Inventors: George M. CHURCH, Luhan YANG, Marc Guell CARGOL, Joyce Lichi YANG
  • Genome Engineering
    Publication number: 20150031132
    Abstract: Methods of genome engineering in cells using a TALEN lacking repeat sequences or Cas9 is provided.
    Type: Application
    Filed: June 30, 2014
    Publication date: January 29, 2015
    Inventors: George M. CHURCH, Luhan YANG, Marc Guell CARGOL, Joyce Lichi YANG