Patents by Inventor Marc H. Gershow

Marc H. Gershow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Study of polymer molecules and conformations with a nanopore
    Patent number: 8969091
    Abstract: The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., a nucleic acid, traverses. As the polymer traverses the nanopore, measurements of transport properties of the nanopore yield data on the conformation of the polymer.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: March 3, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: Jene A. Golovchenko, Jiali Li, Derek Stein, Marc H. Gershow
  • Study of polymer molecules and conformations with a nanopore
    Patent number: 8394640
    Abstract: The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., a nucleic acid, traverses. As the polymer traverses the nanopore, measurements of transport properties of the nanopore yield data on the conformation of the polymer.
    Type: Grant
    Filed: December 6, 2010
    Date of Patent: March 12, 2013
    Assignee: President and Fellows of Harvard College
    Inventors: Jene A. Golovchenko, Jiali Li, Derek Stein, Marc H. Gershow
  • Capture, recapture, and trapping of molecules with a nanopore
    Patent number: 8273532
    Abstract: In a molecular analysis system, there is provided a structure including a nanopore and first and second fluidic reservoirs. The two reservoirs are fluidically connected via the nanopore. A detector is connected to detect molecular species translocation of the nanopore, from one of the two fluidic reservoirs to the other of the two fluidic reservoirs. A controller is connected to generate a control signal to produce conditions at the nanopore to induce the molecular species to re-translocate the nanopore at least once after translocating the nanopore. This enables a method for molecular analysis in which a molecular species is translocated a plurality of times through a nanopore in a structure between two fluidic reservoirs separated by the structure.
    Type: Grant
    Filed: October 2, 2008
    Date of Patent: September 25, 2012
    Assignee: President and Fellows of Harvard College
    Inventors: Marc H. Gershow, Jene A. Golovchenko, Daniel Branton
  • Capture, recapture, and trapping of molecules with a nanopore
    Patent number: 8008014
    Abstract: In a molecular analysis system, there is provided a structure including a nanopore and first and second fluidic reservoirs. The two reservoirs are fluidically connected via the nanopore. A detector is connected to detect molecular species translocation of the nanopore, from one of the two fluidic reservoirs to the other of the two fluidic reservoirs. A controller is connected to generate a control signal to produce conditions at the nanopore to induce the molecular species to re-translocate the nanopore at least once after translocating the nanopore. This enables a method for molecular analysis in which a molecular species is translocated a plurality of times through a nanopore in a structure between two fluidic reservoirs separated by the structure.
    Type: Grant
    Filed: October 2, 2008
    Date of Patent: August 30, 2011
    Assignee: President and Fellows of Harvard College
    Inventors: Marc H. Gershow, Jene A. Golovchenko, Daniel Branton
  • STUDY OF POLYMER MOLECULES AND CONFORMATIONS WITH A NANOPORE
    Publication number: 20110159601
    Abstract: The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., a nucleic acid, traverses. As the polymer traverses the nanopore, measurements of transport properties of the nanopore yield data on the conformation of the polymer.
    Type: Application
    Filed: December 6, 2010
    Publication date: June 30, 2011
    Inventors: Jene A. Golovchenko, Jiali Li, Derek Stein, Marc H. Gershow
  • Study of polymer molecules and conformations with a nanopore
    Patent number: 7846738
    Abstract: The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., a nucleic acid, traverses. As the polymer traverses the nanopore, measurements of transport properties of the nanopore yield data on the conformation of the polymer.
    Type: Grant
    Filed: August 16, 2004
    Date of Patent: December 7, 2010
    Assignee: President and Fellows of Harvard College
    Inventors: Jene A. Golovchenko, Jiali Li, Derek Stein, Marc H. Gershow
  • Capture, recapture, and trapping of molecules with a nanopore
    Publication number: 20090136958
    Abstract: In a molecular analysis system, there is provided a structure including a nanopore and first and second fluidic reservoirs. The two reservoirs are fluidically connected via the nanopore. A detector is connected to detect molecular species translocation of the nanopore, from one of the two fluidic reservoirs to the other of the two fluidic reservoirs. A controller is connected to generate a control signal to produce conditions at the nanopore to induce the molecular species to re-translocate the nanopore at least once after translocating the nanopore. This enables a method for molecular analysis in which a molecular species is translocated a plurality of times through a nanopore in a structure between two fluidic reservoirs separated by the structure.
    Type: Application
    Filed: October 2, 2008
    Publication date: May 28, 2009
    Applicant: President and Fellows of Harvard College
    Inventors: Marc H. Gershow, Jene A. Golovchenko, Daniel Branton