Abstract: Screening methods for identifying compounds and compounds and pharmaceutical compositions for treating and preventing cancer are disclosed. The compounds affect signal transduction downstream of the MET receptor.

Abstract: Screening methods for identifying compounds and compounds and pharmaceutical compositions for treating and preventing cancer are disclosed. The compounds affect signal transduction downstream of the MET receptor.

Abstract: Screening methods for identifying compounds and compounds and pharmaceutical compositions for treating and preventing cancer are disclosed. The compounds affect signal transduction downstream of the MET receptor.

Abstract: Screening methods for identifying compounds and compounds and pharmaceutical compositions for treating and preventing cancer are disclosed. The compounds affect signal transduction downstream of the MET receptor.

Abstract: A thermoplastic polyurethane is obtainable via reaction of the following components A, B, C, and, if appropriate, D and E (e) at least one aliphatic, organic diisocyanate, as component A, (f) at least one compound which is reactive toward component A and which has a weight-average molar mass of from 500 to 10 000 g/mol, as component B, (g) a mixture composed of alkanediols as chain extenders, comprising from 60 to 85 mol % of 1,6-hexanediol as main chain extender C1 and from 15 to 40 mol % of 1,3-propanediol as co-chain extender C2, as component C, (h) at least one catalyst, as component D, (i) conventional additives as component E.

Abstract: The present invention relates to a flame-retardant mixture comprising (A) at least one polyurethane as component A, (B) at least one flame retardant selected from the group consisting of tallow, ammonium phosphate, ammonium polyphosphate, calcium carbonate, antimony oxide, zinc borate, clay, montmorillonite clay, metal oxides, metal hydroxides, organic phosphinate compounds, organic phosphate compounds, polyhydric alcohols, melamine compounds, chlorinated polyethylene, and mixtures thereof, as component B, and (C) at least one crosslinking reagent as component C, where the at least one crosslinking reagent is at least one isocyanate dissolved in at least one polyurethane, and also to a process for the production of a flame-retardant polyurethane, to the resultant flame-retardant polyurethane, and also to the use of a solution of at least one isocyanate in at least one polyurethane in the production of a flame-retardant polyurethane for increasing the mechanical stability of flame-retardant polyurethanes.

Abstract: This disclosure encompasses the edr3 polynucleotide, polypeptides encoded by the edr3 gene and fragments thereof. This disclosure also encompasses homologues of the edr3 gene from mammals, in particular from humans. In addition, this disclosure encompasses the use of edr3 polynucleotides, edr3 proteins and polypeptides, and antibodies to the edr3 protein capable of increasing or decreasing edr3 activity or expression.