Abstract: The present invention relates to piperazinyl derivatives of formula (I) and the use thereof as a drug, particularly for the treatment of cancer, the pharmaceutical compositions containing said derivatives, and the method for synthesising same.

Abstract: This invention relates to a copper thick film paste composition paste comprising copper powder, a Pb-free, Bi-free and Cd-free borosilicate glass frit, ruthenium-based powder, and an organic vehicle. The invention also provides methods of using the copper thick film paste composition to make a copper conductor on a substrate. Typical substrates are selected from the group consisting of aluminum nitride, aluminum oxide and silicon nitride.

Abstract: Provided herein is technology relating to next-generation sequencing (NGS) and particularly, but not exclusively, to methods and compositions for preparing NGS libraries, e.g., to prepare NGS libraries for use in a NGS workflow.

Abstract: This invention relates to a copper thick film paste composition paste comprising copper powder, a Pb-free, Bi-free and Cd-free borosilicate glass frit, a component selected from the group consisting of ruthenium-based powder, copper oxide powder and mixtures thereof and an organic vehicle. The invention also provides methods of using the copper thick film paste composition to make a copper conductor on a substrate. Typical substrates are selected from the group consisting of aluminum nitride, aluminum oxide and silicon nitride.

Abstract: The present invention relates to piperazinyl derivatives of formula (I) and the use thereof as a drug, particularly for the treatment of cancer, the pharmaceutical compositions containing said derivatives, and the method for synthesising same.

Abstract: This invention relates to a copper thick film paste composition paste comprising copper powder, a Pb-free, Bi-free and Cd-free borosilicate glass frit, a component selected from the group consisting of ruthenium-based powder, copper oxide powder and mixtures thereof and an organic vehicle. The invention also provides methods of using the copper thick film paste composition to make a copper conductor on a substrate. Typical substrates are selected from the group consisting of aluminum nitride, aluminum oxide and silicon nitride.

Abstract: This invention provides methods for producing furfural-urea resins and adhesives. The includes dissolving urea in hot water to produce a hot aqueous solution, mixing furfural with the aqueous solution, adding an acid catalyst such as maleic anhydride to the furfural containing aqueous solution upon which a resinification reaction begins immediately. The resinification reaction is quenched by cooling to a pre-selected temperature to produce a resin or adhesive.

Abstract: The invention concerns a novel nucleic acid fragment of the genome of rice pathogenic fungus Magnaporthe grisea comprising a gene coding for a protein (hereafter referred to as gene 763) whereof the presence and integrity are indispensable for pathogenesis of said fungus with respect to rice and barley. The invention also concerns the promoter of said gene, the gene coding for protein 763, protein 763 and uses thereof for identifying potential biological targets for novel fungicide molecules and for isolating genes coding for proteins controlling biochemical functions essential to the pathogenesis of the fungus Magnaporthe grisea with respect to rice and barley. The invention further concerns compounds inhibiting pathogenesis of fungi related to the expression of gene 763.

Abstract: This invention is a method preparing solutions or mixtures of oligimer or polymer in a solution of polymerizable monomer, applying that solution to the surface of a solid porous substance like wood, heating to drive the mixture into the surface zone of the substance and causing the polymerizable monomer to cure. This produces a reinforced, hardened, protective shell around the porous substance.

Abstract: This invention provides methods for preparing mixtures of styrene and maleic anhydride co-monomer, applying that mixture to the surface of a solid porous substance like wood, allowing the mixture to penetrate the surface zone of the material such as wood and causing it to quickly cure in the surface zone of the material. The keys are the low viscosity of the mixture that causes it to penetrate quickly and well, and its reactivity that causes it to cure before it either evaporates or becomes too dispersed within the material. The polymer reinforcement and hardening is therefore effectively restricted to the surface zone or shell. This produces a reinforced, hardened, protective shell around the porous material.

Abstract: This invention provides methods of furfural-urea modification of wood, and more particularly the present invention relates to the impregnation, and polymerization of, furfural-urea formulations under conditions of high weight percent gain (WPG) into wood. Wood is modified by impregnating wood first with furfural, thereafter impregnating the wood with a solution of urea, water and an acidic catalyst for polymerizing the mixture of furfural and urea in the wood. The wood is then dried and cured at the same time.

Abstract: This invention provides methods for producing furfural-urea resins and adhesives. The includes dissolving urea in hot water to produce a hot aqueous solution, mixing furfural with the aqueous solution, adding an acid catalyst such as maleic anhydride to the furfural containing aqueous solution upon which a resinification reaction begins immediately. The resinification reaction is quenched by cooling to a pre-selected temperature to produce a resin or adhesive.

Abstract: This invention provides water-based furfural-urea resins for impregnation of same into wood in order to impart decay, mold, marine borer and termite resistance and improve moisture resistance and mechanical properties. The waterborne wood modification composition for impregnation into wood, includes water, furfural, urea, an acidic catalyst, and a buffer present in an amount to give a pH in a range from about 2.96 to about 5.13.

Abstract: A cable retention system is provided to connect a PC card, for example a PCMCIA card, to a cable. The cable portion includes an electrical connector on a cable that is overmolded with a backshell. The backshell incorporates captivated thumbscrews that can be at least partially withdrawn into the backshell. The thumbscrews may engage threads in the PC card to provide a secure attachment, or the thumbscrews may be withdrawn into the backshell, so that the electrical connector on the cable may be pushed onto the mating electrical connector on the PC card. In another embodiment, an electronic device, such as a wireless or ROM module, is attached to the PC card.

Abstract: Resulphurized austenitic stainless steel with improved machinability, characterized in that its weight composition is the following:carbon lower than or equal to 0.15%silicon lower than or equal to 2%manganese lower than or equal to 2%molybdenum lower than or equal to 3%nickel between 7 and 12%chromium between 15 and 25%sulphur between 0.10 and 0.40%calcium higher than or equal to 30.times.10.sup.-4 %oxygen higher than or equal to 70.times.10.sup.-4 %the ratio of the calcium content and of the oxygen content Ca/O being between 0.2 and 0.6.

Abstract: Hydraulic clatter damping device consisting of a piston mechanically connected to a valve spindle and sliding within a closed composite chamber (20) consisting of two sub-chambers arranged on either side of the piston, namely, a large sub-chamber (23) in the upper part and a compression chamber (24) in the lower part, both chambers being filled with the same hydraulic fluid under pressure, the piston being provided with a hollow deformable body filled with a gaseous fluid, being rigidly connected to its free face in the large sub-chamber and contracted during rest by the pressure prevailing in the sub-chambers. The sub-chambers communicate with a thin-walled nozzle (26), the chamber containing the hollow body comprising a visual communication means which permits its upper face to be observed. The invention relates to the manufacture of safety valves and other safety components.

Abstract: A foundry installation control device is disclosed for causing a rapid cut off of a molten metal flow at the time when a mold is full. Two detectors are provided, one of which collects information concerning the instantaneous rate of metal flow pouring from a ladle into a sprue cup while the other collects information on the level of the molten metal in the cup. An electronic circuit connected to the outputs of the two detectors produces a mold filling signal which undergoes a sharp fluctuation at the precise moment when filling is completed. This signal is compared with an instruction value and causes the generation of a flow cut-off signal which triggers the cessation of pouring by righting of the ladle in the case of a tilting ladle, closing of the stopper in the case of a bottom-pour ladle, or closing the discharge valve in the case of a pressure ladle.

Abstract: A foundry installation control device is disclosed for causing a rapid cut off of a molten metal flow at the time when a mold is full. Two detectors are provided, one of which collects information concerning the instantaneous rate of metal flow pouring from a ladle into a sprue cup while the other collects information on the level of the molten metal in the cup. An electronic circuit connected to the outputs of the two detectors produces a mold filling signal which undergoes a sharp fluctuation at the precise moment when filling is completed. This signal is compared with an instruction value and causes the generation of a flow cut-off signal which triggers the cessation of pouring by righting of the ladle in the case of a tilting ladle, closing of the stopper in the case of a bottom-pour ladle, or closing the discharge valve in the case of a pressure ladle.