Patents by Inventor Marc I. DAMELIN

Marc I. DAMELIN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SITE SPECIFIC ANTIBODY-DRUG CONJUGATES WITH PEPTIDE-CONTAINING LINKERS
    Publication number: 20240148887
    Abstract: The present disclosure relates generally to antibody-drug conjugates comprising peptide-containing linkers and to methods of using these conjugates as therapeutics and/or diagnostics. Also disclosed herein are peptide-containing scaffolds useful to conjugate with a targeting moiety (e.g., an antibody), a drug, or both to produce the antibody-drug conjugates.
    Type: Application
    Filed: August 30, 2023
    Publication date: May 9, 2024
    Inventors: Timothy B. LOWINGER, Marc I. Damelin, Dorin Toader
  • B7H4-targeted antibody-drug conjugates and methods of use thereof
    Patent number: 11964024
    Abstract: The present disclosure relates generally to antibody-drug conjugates comprising monoclonal antibodies that specifically bind the human B7-H4 in soluble form, or membrane bound (i.e., when expressed on a cell surface) and to methods of using these conjugates as therapeutics and/or diagnostics.
    Type: Grant
    Filed: January 4, 2022
    Date of Patent: April 23, 2024
    Assignee: Mersana Therapeutics, Inc.
    Inventors: Timothy B. Lowinger, Chen-Ni Chin, Marc I. Damelin, Dorin Toader
  • ANTIBODY DRUG CONJUGATES COMPRISING STING AGONISTS, COMBINATIONS AND METHODS OF USE
    Publication number: 20230398229
    Abstract: The present disclosure provides combinations comprising HER2-targeted STING agonist antibody-drug conjugates and HER2-targeted therapies or immunotherapies. The present disclosure also provides uses of the combinations in treatment, e.g., treatment of cancer.
    Type: Application
    Filed: March 7, 2023
    Publication date: December 14, 2023
    Inventors: Raghida A. BUKHALID, Naniye Cetinbas, Marc I. Damelin, Timothy B. Lowinger, Dorin Toader
  • Site specific antibody-drug conjugates with peptide-containing linkers
    Patent number: 11786605
    Abstract: The present disclosure relates generally to antibody-drug conjugates comprising peptide-containing linkers and to methods of using these conjugates as therapeutics and/or diagnostics. Also disclosed herein are peptide-containing scaffolds useful to conjugate with a targeting moiety (e.g., an antibody), a drug, or both to produce the antibody-drug conjugates.
    Type: Grant
    Filed: January 8, 2021
    Date of Patent: October 17, 2023
    Assignee: Mersana Therapeutics, Inc.
    Inventors: Timothy B. Lowinger, Marc I. Damelin, Dorin Toader
  • ANTIBODY DRUG CONJUGATES COMPRISING STING AGONISTS
    Publication number: 20230321048
    Abstract: The present disclosure provides scaffolds and antibody-drug conjugates (ADCs) comprising a stimulator of interferon genes (STING). The present disclosure also provides uses of the ADCs in treatment, e.g., treatment of cancer.
    Type: Application
    Filed: December 19, 2022
    Publication date: October 12, 2023
    Inventors: Jeremy R. DUVALL, Keith W. BENTLEY, Raghida A. BUKHALID, Naniye CETINBAS, Marc I. DAMELIN, Eugene W. KELLEHER, Timothy B. LOWINGER, Joshua D. THOMAS, Dorin TOADER, Ling XU, Liping YANG
  • ANTIBODY DRUG CONJUGATES COMPRISING STING AGONISTS
    Publication number: 20230172910
    Abstract: The present disclosure provides scaffolds and antibody-drug conjugates (ADCs) comprising a stimulator of interferon genes (STING). The present disclosure also provides uses of the ADCs in treatment, e.g., treatment of cancer.
    Type: Application
    Filed: December 20, 2022
    Publication date: June 8, 2023
    Inventors: Jeremy R. DUVALL, Keith W. BENTLEY, Raghida A. BUKHALID, Naniye CETINBAS, Marc I. DAMELIN, Eugene W. KELLEHER, Timothy B. LOWINGER, Joshua D. THOMAS, Dorin TOADER, Ling XU, Liping YANG
  • ANTIBODY DRUG CONJUGATES COMPRISING STING AGONISTS
    Publication number: 20220378749
    Abstract: The present disclosure provides scaffolds and antibody-drug conjugates (ADCs) comprising a stimulator of interferon genes (STING). The present disclosure also provides uses of the ADCs in treatment, e.g., treatment of cancer.
    Type: Application
    Filed: April 2, 2021
    Publication date: December 1, 2022
    Inventors: Jeremy R. DUVALL, Keith W. BENTLEY, Raghida A. BUKHALID, Naniye CETINBAS, Marc I. DAMELIN, Eugene W. KELLEHER, Timothy B. LOWINGER, Joshua D. THOMAS, Dorin TOADER, Ling XU, Liping YANG
  • B7H4-TARGETED ANTIBODY-DRUG CONJUGATES AND METHODS OF USE THEREOF
    Publication number: 20220233707
    Abstract: The present disclosure relates generally to antibody-drug conjugates comprising monoclonal antibodies that specifically bind the human B7-H4 in soluble form, or membrane bound (i.e., when expressed on a cell surface) and to methods of using these conjugates as therapeutics and/or diagnostics.
    Type: Application
    Filed: January 4, 2022
    Publication date: July 28, 2022
    Inventors: Timothy B. LOWINGER, Chen-Ni CHIN, Marc I. DAMELIN, Dorin TOADER
  • SITE SPECIFIC ANTIBODY-DRUG CONJUGATES WITH PEPTIDE-CONTAINING LINKERS
    Publication number: 20210220477
    Abstract: The present disclosure relates generally to antibody-drug conjugates comprising peptide-containing linkers and to methods of using these conjugates as therapeutics and/or diagnostics. Also disclosed herein are peptide-containing scaffolds useful to conjugate with a targeting moiety (e.g., an antibody), a drug, or both to produce the antibody-drug conjugates.
    Type: Application
    Filed: January 8, 2021
    Publication date: July 22, 2021
    Inventors: Timothy B. LOWINGER, Marc I. DAMELIN, Dorin TOADER