Patents by Inventor Marc I Diamond

Marc I Diamond has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230288432
    Abstract: The present disclosure provides methods for the identification, characterization and ranking of putative tau monomer stabilizing agents. Specifically, the disclosure provides methods for assessing the capability of a test compound to stabilize a tau monomer, methods of prioritizing a plurality of test compounds from a library identified as tau monomer stabilizing agents, methods of screening a test compound library to identify tau monomer stabilizing agents, and a kit providing the reagents to perform the described methods.
    Type: Application
    Filed: July 2, 2021
    Publication date: September 14, 2023
    Inventors: Marc I. DIAMOND, Jaime VAQUER-ALICEA, Gianna C. MAGGIORE
  • Publication number: 20220273779
    Abstract: The disclosure provides methods and compositions for treating and diagnosing tauopathies. More specifically, the disclosure relates to the identification of epitopes on tau and their use as vaccines or as reagents to generate monoclonal antibodies that can be used for both diagnosis and treatment of tau-related diseases.
    Type: Application
    Filed: November 18, 2019
    Publication date: September 1, 2022
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Marc I. DIAMOND, Kenneth DROMBOSKY, Dailu CHEN, Victor MANON, Xiaohua LIU, Hamid MIRZAEI, Jaime VAQUER-ALICEA, Hilda MIRBAHA, Lukasz A. JOACHIMIAK
  • Patent number: 8580773
    Abstract: The present invention provides tetrahydropyrvinium (THP), derivatives thereof, benzoxazole compounds, and derivatives thereof. The present invention provides a method of using tetrahydropyrvinium (THP), derivatives thereof, benzoxazole compounds, and derivatives thereof.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: November 12, 2013
    Assignee: The Regents of the University of California
    Inventors: Marc I. Diamond, Jeremy O. Jones, Adam R. Renslo
  • Patent number: 7803559
    Abstract: Disclosed herein is a high-throughput assay to measure intracellular polyglutamine protein aggregation using fluorescence resonance energy transfer (FRET). Three libraries of over 3000 biologically active small molecules were screened for inhibitory activity, and a lead compound was characterized in detail. Y-27632, an inhibitor of the Rho-associated kinase p160ROCK, diminished polyglutamine protein aggregation at micromolar concentrations, and reduced neurodegeneration in a Drosophila model of polyglutamine disease.
    Type: Grant
    Filed: August 9, 2004
    Date of Patent: September 28, 2010
    Assignee: The Regents of the University of CA
    Inventors: Marc I Diamond, Sonia K Pollitt