Abstract: The present disclosure provides methods for enhancing a therapeutic outcome in a subject having a musculoskeletal condition or disorder, comprising administering at least one senolytic agent and/or at least one anti-fibrotic agent to the subject.

Abstract: A system and method for forming a hip implant offering minimal invasiveness is described. The system comprises means for positioning the implant under optical and X-ray control, an implant and an applicator for screwing and expanding the implant. The implant includes an insert body and an expansion tube with cut-outs and slits defining legs. The legs expand radially through windows in the insert body when the expansion tube is pushed against the sloped distal portion of the insert body. The expansion process may be ensured by using an anti-rotation device to prevent the insertion tube from rotating within the insert body. Applicator and implant are provided with means preventing cold welding during the implantation process.

Abstract: The present disclosure provides method of detecting senescent cells in a cell sample and methods of treating a disease, disorder, or condition associated with senescence in a subject by administering at least one senolytic agent to the subject.

Abstract: A system and method for forming a hip implant offering minimal invasiveness is described. The system comprises means for positioning the implant under optical and X-ray control, an implant and an applicator for screwing and expanding the implant. The implant includes an insert body and an expansion tube with cut-outs and slits defining legs. The legs expand radially through windows in the insert body when the expansion tube is pushed against the sloped distal portion of the insert body. The expansion process may be ensured by using an anti-rotation device to prevent the insertion tube from rotating within the insert body. Applicator and implant are provided with means preventing cold welding during the implantation process.

Abstract: A system and method for forming a hip implant offering minimal invasiveness is described. The system comprises means for positioning the implant under optical and X-ray control, an implant and an applicator for screwing and expanding the implant. The implant includes an insert body and an expansion tube with cut-outs and slits defining legs. The legs expand radially through windows in the insert body when the expansion tube is pushed against the sloped distal portion of the insert body. The expansion process may be ensured by using an anti-rotation device to prevent the insertion tube from rotating within the insert body. Applicator and implant are provided with means preventing cold welding during the implantation process.

Abstract: An anchor delivery tool is described. The tool includes a shaft and a handle coupled to a proximal portion of the shaft. The handle includes a hub, with a knob and a nose cone coupled to the hub. The knob and nose cone may be spring loaded so as to selectively retain a length of suture disposed therebetween. The tool further includes an anchor, such as a suture anchor, coupled to a distal portion of the shaft.

Abstract: A device for accessing and distending a joint comprises a distraction structure having a generally tapered distal portion adapted to penetrate a tissue region and create an access space within a joint. The distraction structure also includes a lumen extending from a proximal surface to a distal portion. The device further includes a distention structure deployable through the lumen and adapted to exert a force between a first joint surface and a second joint surface and create a working space. The distention structure may, in some embodiments, include an elongate member having a proximal end, a distal end, and a lumen extending along at least a portion of the length of the elongate member, a first expandable region deployable from a first substantially collapsed position to a second substantially expanded position, the first expandable region adapted to exert a force between the first joint surface from the second joint surface.

Abstract: An anchor delivery system is described. The system includes a guide and an anchor delivery tool disposed within the guide. The tool includes a shaft and a handle coupled to a proximal portion of the shaft. The handle includes a hub and a nose cone coupled to the hub. In an embodiment, the tool further includes a knob coupled to the hub and located between the handle and the nose cone. In an embodiment, the system further includes an anchor, such as a suture anchor, coupled to a distal portion of the shaft. An anchor delivery tool and a method of repairing soft tissue are also described.

Abstract: An apparatus for elevating tissue within a body, including a tubular member having a proximal end and a distal end and a central axis defined therethrough, in which the tubular member comprises a first lumen and a second lumen, separately formed therein, a balloon secured to a region of the tubular member, in which a region of the tubular member is engagable with an injection mechanism, in which the engaged injection mechanism is engagable to be in communication with the first lumen of the tubular member, and in which the first lumen of the tubular member provides a path to an interior of the balloon.

Abstract: A system and method for forming a hip implant offering minimal invasiveness is described. The system comprises means for positioning the implant under optical and X-ray control, an implant and an applicator for screwing and expanding the implant. The implant includes an insert body and an expansion tube with cut-outs and slits defining legs. The legs expand radially through windows in the insert body when the expansion tube is pushed against the sloped distal portion of the insert body. The expansion process may be ensured by using an anti-rotation device to prevent the insertion tube from rotating within the insert body. Applicator and implant are provided with means preventing cold welding during the implantation process.

Abstract: A device for accessing and distending a joint comprises a distraction structure having a generally tapered distal portion adapted to penetrate a tissue region and create an access space within a joint. The distraction structure also includes a lumen extending from a proximal surface to a distal portion. The device further includes a distention structure deployable through the lumen and adapted to exert a force between a first joint surface and a second joint surface and create a working space. The distention structure may, in some embodiments, include an elongate member having a proximal end, a distal end, and a lumen extending along at least a portion of the length of the elongate member, a first expandable region deployable from a first substantially collapsed position to a second substantially expanded position, the first expandable region adapted to exert a force between the first joint surface from the second joint surface.

Abstract: An apparatus for elevating tissue within a body, including a tubular member having a proximal end and a distal end and a central axis defined therethrough, in which the tubular member comprises a first lumen and a second lumen, separately formed therein, a balloon secured to a region of the tubular member, in which a region of the tubular member is engagable with an injection mechanism, in which the engaged injection mechanism is engagable to be in communication with the first lumen of the tubular member, and in which the first lumen of the tubular member provides a path to an interior of the balloon.

Abstract: The present disclosure relates to an anchor delivery system. The system includes a guide and an anchor delivery tool disposed within the guide. The tool includes a shaft and a handle coupled to a proximal portion of the shaft. The handle includes a hub and a nose cone coupled to the hub. In an embodiment, the tool further includes a knob coupled to the hub and located between the handle and the nose cone. In an embodiment, the system further includes an anchor, such as a suture anchor, coupled to a distal portion of the shaft. An anchor delivery tool and a method of repairing soft tissue are also disclosed.

Abstract: An apparatus for elevating tissue within a body, including a tubular member having a proximal end and a distal end and a central axis defined therethrough, in which the tubular member comprises a first lumen and a second lumen, separately formed therein, a balloon secured to a region of the tubular member, in which a region of the tubular member is engagable with an injection mechanism, in which the engaged injection mechanism is engagable to be in communication with the first lumen of the tubular member, and in which the first lumen of the tubular member provides a path to an interior of the balloon.

Abstract: The present disclosure relates to an anchor delivery system. The system includes a guide and an anchor delivery tool disposed within the guide. The tool includes a shaft and a handle coupled to a proximal portion of the shaft. The handle includes a hub and a nose cone coupled to the hub. In an embodiment, the tool further includes a knob coupled to the hub and located between the handle and the nose cone. In an embodiment, the system further includes an anchor, such as a suture anchor, coupled to a distal portion of the shaft. An anchor delivery tool and a method of repairing soft tissue are also disclosed.

Abstract: An apparatus for elevating tissue within a body, including a tubular member having a proximal end and a distal end and a central axis defined therethrough, in which the tubular member comprises a first lumen and a second lumen, separately formed therein, a balloon secured to a region of the tubular member, in which a region of the tubular member is engagable with an injection mechanism, in which the engaged injection mechanism is engagable to be in communication with the first lumen of the tubular member, and in which the first lumen of the tubular member provides a path to an interior of the balloon.

Abstract: The present disclosure relates to a guide. The guide includes a handle and a shaft coupled to the handle, the shaft including a lip located at a distance from the longitudinal axis of the shaft and extending a distance from an end of the shaft. A method of tissue repair is also disclosed.

Abstract: The present disclosure relates to an anchor delivery system. The system includes a guide and an anchor delivery tool disposed within the guide. The tool includes a shaft and a handle coupled to a proximal portion of the shaft. The handle includes a hub and a nose cone coupled to the hub. In an embodiment, the tool further includes a knob coupled to the hub and located between the handle and the nose cone. In an embodiment, the system further includes an anchor, such as a suture anchor, coupled to a distal portion of the shaft. An anchor delivery tool and a method of repairing soft tissue are also disclosed.