Patents by Inventor Marc Key

Marc Key has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10495553
    Abstract: The present disclosure relates to an aqueous sealing fluid for sealing a stained biological specimen present on a microscope slide for microscopic analysis. The sealing fluid protects the biological specimen from drying artifacts, protects stains performed on biological specimen from fading, and protects stains performed on biological specimens from being dissolved by organic mounting media. Methods of using the aqueous sealing fluid are also disclosed.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: December 3, 2019
    Assignees: Diagnostic BioSystems
    Inventor: Marc Key
  • Patent number: 10379015
    Abstract: A method for labeling concentration density differentials of an analyte in a biological sample is provided. The method may including the steps of: binding an enzyme to an analyte contained in a sample, the enzyme capable of acting on at least two chromogens; incubating the sample with a first chromogen for a first time period to generate a first color chromogen-enzyme product, the first color chromogen-enzyme product reflecting light observable as a first color; and incubating the sample with a second chromogen for a second time period to generate a second color chromogen-enzyme product, the second color chromogen-enzyme product reflecting light observable as second color. A combination of the light observable as the first color and the light observable as the second color may be observable as a third color, and each color may describe a different analyte density in the biological sample.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: August 13, 2019
    Assignees: Diagnostic BioSystems
    Inventors: Bipin Gupta, Marc Key
  • Patent number: 10281374
    Abstract: Disclosed are methods for treating a biological sample for an analyte-staining assay. These methods are conducted with the use of a single aqueous multi-functional composition for the purposes of performing the steps of deparaffinization, rehydration, antigen retrieval and endogenous enzyme blocking simultaneously optionally at an elevated temperature. These methods are alternatively conducted with use of a single aqueous multi-functional composition that contains a thermostable protease for the purpose of deparaffinization, rehydration, antigen retrieval and endogenous enzyme blocking at an elevated temperature.
    Type: Grant
    Filed: September 4, 2016
    Date of Patent: May 7, 2019
    Assignees: Diagnostic BioSystems
    Inventors: Marc Key, Bipin Gupta
  • Patent number: 10280445
    Abstract: The present disclosure relates methods of chromogen layering, wherein a first chromogen and a first stain (color) are produced on a sample, specific for a first analyte, followed by a second chromogen and a second stain (color) being produced on the same sample, specific for a second analyte. In addition, if desired, by overlaying the second stain on top of the first stain, a unique third color is produced that is specific for a third analyte. Therefore, the distribution of different colors throughout the sample could be used to identify at least two or more analytes simultaneously within a single sample.
    Type: Grant
    Filed: July 16, 2017
    Date of Patent: May 7, 2019
    Assignees: Diagnostic BioSystems, Marc Key
    Inventors: Bipin Gupta, Marc Key
  • Publication number: 20190128784
    Abstract: A deparaffinizing composition and method are provided for removing paraffin wax from biological samples. The deparaffinizing composition may include: a paraffin solvent that may be a first apolar paraffin solvent; a second apolar solvent that may be at least partially miscible with water; a first polar solvent that may be miscible with both water and apolar solvents; a second polar solvent that may be water; and a detergent. The deparaffinizing method may include the steps of: incubating the sample for a time period in a deparaffinizing composition; and rinsing the sample with an aqueous buffer. Preferably, the step of incubating the sample for a time period in the deparaffinizing composition may include heating the sample and the composition to between approximately 35 to 65 degrees Celsius.
    Type: Application
    Filed: August 24, 2018
    Publication date: May 2, 2019
    Inventors: Bipin Gupta, Marc Key
  • Patent number: 10156580
    Abstract: A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: December 18, 2018
    Assignee: DAKO DENMARK A/S
    Inventors: Gordon Feingold, Marc Key, John Favuzzi, Rosanne Welcher
  • Publication number: 20180348099
    Abstract: A method for labeling concentration density differentials of an analyte in a biological sample is provided. The method may including the steps of: binding an enzyme to an analyte contained in a sample, the enzyme capable of acting on at least two chromogens; incubating the sample with a first chromogen for a first time period to generate a first color chromogen-enzyme product, the first color chromogen-enzyme product reflecting light observable as a first color; and incubating the sample with a second chromogen for a second time period to generate a second color chromogen-enzyme product, the second color chromogen-enzyme product reflecting light observable as second color. A combination of the light observable as the first color and the light observable as the second color may be observable as a third color, and each color may describe a different analyte density in the biological sample.
    Type: Application
    Filed: September 29, 2017
    Publication date: December 6, 2018
    Applicant: Diagnostic BioSystems
    Inventors: Bipin Gupta, Marc Key
  • Publication number: 20180258463
    Abstract: The present disclosure relates methods of chromogen layering, wherein a first chromogen and a first stain (color) are produced on a sample, specific for a first analyte, followed by a second chromogen and a second stain (color) being produced on the same sample, specific for a second analyte. In addition, if desired, by overlaying the second stain on top of the first stain, a unique third color is produced that is specific for a third analyte. Therefore, the distribution of different colors throughout the sample could be used to identify at least two or more analytes simultaneously within a single sample.
    Type: Application
    Filed: July 16, 2017
    Publication date: September 13, 2018
    Applicant: DIAGNOSTIC BIOSYSTEMS
    Inventors: BIPIN GUPTA, MARC KEY
  • Publication number: 20170299482
    Abstract: The present disclosure relates to counterstains for staining a biological sample on a single slide in preparation for microscopic examination. The counterstains are used to analyze the sample on the single slide using both brightfield and fluorescent illumination. The counterstains can identify both morphological details and molecular structures within the cells contained in the sample. The counterstains can be used in conjunction with other molecular stains.
    Type: Application
    Filed: April 4, 2017
    Publication date: October 19, 2017
    Applicant: DIAGNOSTIC BIOSYSTEMS
    Inventor: MARC KEY
  • Patent number: 9778273
    Abstract: A sample processing system 101 that may be automated and methods are disclosed where a number of sample processing systems 101, such as stainer, may be connected to a number of separate full function computers 181 through a stainer network 183 that may be isolated from other communication traffic. A network configuration may permit scalability and addressability so that additional sample processing systems 101, additional separate full function computers 181, and additional other devices such as label printers 200 may be easily added to the system. One or more remote information links 171 may be provided so that information transfer on a continuous or perhaps constant basis can be accommodated.
    Type: Grant
    Filed: December 22, 2003
    Date of Patent: October 3, 2017
    Assignee: Dako Denmark A/S
    Inventors: Gordon Feingold, Marc Key
  • Publication number: 20170167956
    Abstract: The present disclosure relates to an aqueous sealing fluid for sealing a stained biological specimen present on a microscope slide for microscopic analysis. The sealing fluid protects the biological specimen from drying artifacts, protects stains performed on biological specimen from fading, and protects stains performed on biological specimens from being dissolved by organic mounting media. Methods of using the aqueous sealing fluid are also disclosed.
    Type: Application
    Filed: December 14, 2016
    Publication date: June 15, 2017
    Applicant: DIAGNOSTIC BIOSYSTEMS
    Inventor: MARC KEY
  • Publication number: 20170122850
    Abstract: Disclosed are methods for treating a biological sample for an analyte-staining assay. These methods are conducted with the use of a single aqueous multi-functional composition for the purposes of performing the steps of deparaffinization, rehydration, antigen retrieval and endogenous enzyme blocking simultaneously optionally at an elevated temperature. These methods are alternatively conducted with use of a single aqueous multi-functional composition that contains a thermostable protease for the purpose of deparaffinization, rehydration, antigen retrieval and endogenous enzyme blocking at an elevated temperature.
    Type: Application
    Filed: September 4, 2016
    Publication date: May 4, 2017
    Inventors: Marc Key, Bipin Gupta
  • Patent number: 9599630
    Abstract: The present invention concerns an apparatus for staining tissue samples, said apparatus including a reagent section or reagent containers; at least one staining section or tissue samples, a robotic head or robotic element that may move reagent to a predetermined tissue sample, said robotic element being moveable above the reagent and the staining sections, a control element that may manage a staining process, a 2-D optical sensor to detect two-dimensional image data of a relevant property and that can feed the captured image data to the control element. By providing the robotic element with a 2-D optical sensor, a common image processor may be provided having multiple functions. By using a 2-D optical image processing system, the control system of the apparatus may easily be adapted to read various types of data presentations, just as actual images for sections of the apparatus may be identified in order to assess the condition of the apparatus.
    Type: Grant
    Filed: January 9, 2014
    Date of Patent: March 21, 2017
    Assignee: DAKO DENMARK A/S
    Inventors: Doug Sweet, Marc Key, Gordon Feingold, Kristopher Buchanan, Bob Lathrop, John Favuzzi
  • Publication number: 20160232292
    Abstract: Disclosed are techniques for implementing knowledge base-driven generation of immunoassay protocols and procedures. These techniques invoke an expert system or knowledge engineering base to identify or determine one or more proteins of interest for one or more tumor types of interest or a disease group of interest and further invoke a protocol generation module that is stored at least partially in memory and includes or functions in tandem with one or more processors of a computing system to generate a concurrent or a sequential immunoassay protocol based in part or in whole upon one or more immunoassay protocol rules and the one or more tumor types of interest or a disease group of interest. These techniques may further invoke an immunoassay procedure generation module to generate a sequential or concurrent immunoassay procedure based in part or in whole upon one or more immunoassay experimental conditions.
    Type: Application
    Filed: February 5, 2016
    Publication date: August 11, 2016
    Inventors: Marc Key, Bipin Gupta
  • Publication number: 20160084862
    Abstract: A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.
    Type: Application
    Filed: December 4, 2015
    Publication date: March 24, 2016
    Inventors: Gordon Feingold, Marc Key, John Favuzzi, Rosanne Welcher
  • Patent number: 9229016
    Abstract: A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: January 5, 2016
    Assignee: Dako Denmark A/S
    Inventors: Gordon Feingold, Marc Key, John Favuzzi, Rosanne Welcher
  • Patent number: 9040284
    Abstract: Systems and methods of sample processing and temperature control are disclosed. The invention may especially relate to temperature control, and may in some embodiments be methods of temperature control of an automated sample processing system and methods of automated sample processing. Specifically, the present invention provides temperature control in relation to sample processing systems and methods of processing samples, and in some embodiments provides temperature control in relation to sample carriers and processing materials such as reagents. Corresponding systems and devices are disclosed, including sample processing systems (1), sample carrier temperature regulation systems (60), reagent temperature regulation systems, sample processing control systems, and temperature regulation devices, among other embodiments.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: May 26, 2015
    Assignee: DAKO DENMARK A/S
    Inventors: Kristopher Buchanan, Marc Key, John Favuzzi, Rosanne Welcher, Benno Guggenheimer, Robert Clark, Michael Barber, Bob Lathrop
  • Patent number: 8969086
    Abstract: A sample processing system 101 that may be automated and methods are disclosed where sample(s) 198 are arranged on a carrier element 197 and a process operation control system 171 automatically processes the sample(s) perhaps robotically according to an desired aggregation of event dictated by an input 173. Alteration of an initial aggregated event topology may be accepted while the system is processing an initial aggregation and varied-parameter robotic control simulation functionalities 606 may be accomplished to determine an enhanced sequence for processing. Suggested operator actions may be displayed that might further enhance the scheduling of the altered aggregated event topology together with an automatic operator need prompt 608 that may inform an operator of a need for a particular action in order to accomplish the desired tasks.
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: March 3, 2015
    Assignee: Dako Denmark A/S
    Inventors: Marc Key, Gordon Feingold, Rosanne Welcher
  • Publication number: 20140356935
    Abstract: A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.
    Type: Application
    Filed: June 17, 2014
    Publication date: December 4, 2014
    Inventors: Gordon Feingold, Marc Key, John Favuzzi, Rosanne Welcher
  • Publication number: 20140286838
    Abstract: The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.
    Type: Application
    Filed: June 9, 2014
    Publication date: September 25, 2014
    Inventors: Lars Winther, Marc Key, Kristopher Buchanan, John Favuzzi, Benno Guggenheimer