Patents by Inventor Marc Kolkman

Marc Kolkman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250034609
    Abstract: Disclosed are compositions and methods relating to engineered ?-amylases. The engineered ?-amy lases outperform commercial combinatoral variant ?-amylases, which are currently the industry standard. The engineered ?-amylases are useful for starch liquefaction and saccharification, and may also be useful for cleaning starchy stains, textile desizing, baking, and brewing.
    Type: Application
    Filed: November 18, 2022
    Publication date: January 30, 2025
    Inventors: Veli ALKAN, Marc KOLKMAN, Frank KOOPMAN, Sang-kyu LEE, Chris LEEFLANG, Kefeng NI, Sina PRICELIUS, Zhen QIAN, Zhongmei TANG, Marco VAN BRUSSEL-ZWIJNEN
  • Patent number: 12146173
    Abstract: The present disclosure relates to serine proteases and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.
    Type: Grant
    Filed: June 30, 2022
    Date of Patent: November 19, 2024
    Assignee: Danisco US Inc.
    Inventors: Marc Kolkman, Anja Hemmingsen Kellett-Smith, Rie Mejldal, Lilia Maria Babe
  • Publication number: 20240360430
    Abstract: The present disclosure is generally related to recombinant microbial cells expressing heterologous proteins of interest. Certain aspects of the disclosure are therefore related to, inter alia, recombinant Bacillus cells having enhanced protein production capabilities, novel protein signal sequences, recombinant polynucleotides encoding heterologous proteins of interest, and related compositions and/or methods thereof. Thus, as exemplified herein, the recombinant Bacillus cells of the instant disclosure are particularly suitable for use in the expression, production and secretion of heterologous proteins.
    Type: Application
    Filed: August 19, 2022
    Publication date: October 31, 2024
    Inventors: Ryan L. Frisch, Wonchul Suh, Chris Leeflang, Marc Kolkman, Hongxian He
  • Publication number: 20240301384
    Abstract: The present disclosure relates to serine proteases and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.
    Type: Application
    Filed: April 15, 2024
    Publication date: September 12, 2024
    Inventors: MARC KOLKMAN, RIE MEJLDAL, ANJA HEMMINGSEN KELLETT-SMITH, LILIA MARIA BABE
  • Patent number: 11987825
    Abstract: The present disclosure relates to serine proteases and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.
    Type: Grant
    Filed: June 2, 2021
    Date of Patent: May 21, 2024
    Assignee: Danisco US Inc.
    Inventors: Marc Kolkman, Rie Mejldal, Anja Hemmingsen Kellett-Smith, Lilia Maria Babe
  • Patent number: 11859216
    Abstract: Bacillus agaradhaerens strain WDG185 expresses an inulosucrase that efficiently synthesizes a broad range of IOS with a GF range of GF3-GF30. The isolated and/or purified inulosucrase, recombinantly engineered variants thereof, active fragments thereof, synthetic nucleic acids encoding the inulosucrase, its variants, or its active fragments, host cells comprising the synthetic nucleic acids, and compositions comprising the inulosucrase are provided. Methods of using the compositions include the manufacture of inulooligosaccharides.
    Type: Grant
    Filed: September 17, 2020
    Date of Patent: January 2, 2024
    Assignee: Danisco US Inc.
    Inventors: Slavko Kralj, Marc Kolkman, Chris Leeflang, Johannes G. De Nobel, Arjen Hoekstra, Veli Alkan
  • Publication number: 20230348879
    Abstract: Disclosed are compositions and methods relating to variant alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.
    Type: Application
    Filed: September 1, 2022
    Publication date: November 2, 2023
    Inventors: LUIS G CASCAO-PEREIRA, DINA FINAN, DAVID EDWARD WILDES, PIETER AUGUSTINUS, ROEL HERMANT, MONICA OCHA RUIZ, DEWY VAN TOL, RICHARD R. BOTT, MARC KOLKMAN
  • Publication number: 20220333092
    Abstract: The present disclosure relates to serine proteases and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.
    Type: Application
    Filed: June 30, 2022
    Publication date: October 20, 2022
    Inventors: Marc Kolkman, Anja Hemmingsen Kellett-Smith, Rie Mejldal, Lilia Maria Babe
  • Patent number: 11447782
    Abstract: The instant disclosure is generally related to novel engineered (hybrid) promoters. In certain embodiments, the instant disclosure is directed to one or more nucleic acid compositions comprising engineered promoters operably linked to nucleic acids encoding proteins of interest. Thus, the disclosure set forth herein described methods and compositions for the production of proteins of interest using one or more novel engineered (hybrid) promoters of the disclosure.
    Type: Grant
    Filed: March 6, 2017
    Date of Patent: September 20, 2022
    Assignee: DANISCO US INC.
    Inventors: Cristina Bongiorni, Marc Kolkman, Chris Leeflang, Virgil Arthur Rhodius, Anita Van Kimmenade
  • Patent number: 11384348
    Abstract: The present disclosure relates to serine proteases cloned from Bacillus gibsonii, and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.
    Type: Grant
    Filed: December 4, 2019
    Date of Patent: July 12, 2022
    Assignee: DANISCO US INC
    Inventors: Marc Kolkman, Frits Goedegebuur, Lilia Maria Babe, Rie Mejldal, Harm Mulder, Anja Hemmingsen Kellett-Smith, Richard R Bott, Miles Christopher Scotcher
  • Publication number: 20220002685
    Abstract: Bacillus agaradhaerens strain WDG185 expresses an inulosucrase that efficiently synthesizes a broad range of IOS with a GF range of GF3-GF30. The isolated and/or purified inulosucrase, recombinantly engineered variants thereof, active fragments thereof, synthetic nucleic acids encoding the inulosucrase, its variants, or its active fragments, host cells comprising the synthetic nucleic acids, and compositions comprising the inulosucrase are provided. Methods of using the compositions include the manufacture of inulooligosaccharides.
    Type: Application
    Filed: September 17, 2020
    Publication date: January 6, 2022
    Applicant: DANISCO US INC.
    Inventors: Slavko KRALJ, Marc Kolkman, Chris Leeflang, Johannes G. De Nobel, Arjen Hoekstra, Veli Alkan
  • Publication number: 20210395715
    Abstract: The present disclosure relates to serine proteases and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.
    Type: Application
    Filed: June 2, 2021
    Publication date: December 23, 2021
    Inventors: Marc Kolkman, Rie Mejldal, Anja Hemmingsen Kellett-Smith, Lilia Maria Babe
  • Patent number: 11008559
    Abstract: The present disclosure relates to serine proteases cloned from Bacillus Akibai and Bacillus Clarkii, and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: May 18, 2021
    Assignee: DANISCO US INC
    Inventors: Marc Kolkman, Rie Mejldal, Anja Hemmingsen Kellett Smith, Lilia Maria Babe, Richard R. Bott
  • Publication number: 20200407703
    Abstract: The present disclosure relates to serine proteases cloned from Bacillus spp., and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.
    Type: Application
    Filed: September 17, 2020
    Publication date: December 31, 2020
    Inventors: MARC KOLKMAN, Anja Hemmingsen Kellett-Smith, Rie Mejldal, Richard R. Bott, Lilia Marie Babe
  • Publication number: 20200362326
    Abstract: The present disclosure relates to serine proteases and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.
    Type: Application
    Filed: January 27, 2020
    Publication date: November 19, 2020
    Inventors: Marc Kolkman, Anja Hemmingsen Kellett-Smith, Rie Mejldal, Lilia Maria Babe
  • Publication number: 20200291374
    Abstract: Aspects of the present compositions and methods relate to novel metalloproteases, polynucleotides encoding the novel metalloproteases, and compositions and methods for use thereof.
    Type: Application
    Filed: May 22, 2020
    Publication date: September 17, 2020
    Inventors: LILIA M. BABE, FRITS GOEDEGEBUUR, ROOPA GHIRNIKAR, XIAOGANG GU, MARC KOLKMAN, JIAN YAO
  • Publication number: 20200277590
    Abstract: The present disclosure relates to endo-beta-mannanases from Paenibacillus and Bacillus spp., polynucleotides encoding such endo-beta-mannanases, compositions containing such mannanases, and methods of use thereof. Compositions containing such endo-beta-mannanases are suitable for use as detergents and cleaning fabrics and hard surfaces, as well as a variety of other industrial applications.
    Type: Application
    Filed: September 20, 2019
    Publication date: September 3, 2020
    Inventors: Christian D. Adams, Roopa Santosh Ghirnikar, Victoria Huang, Marc Kolkman, Zhen Qian, Liling Jin
  • Publication number: 20200248160
    Abstract: The present disclosure relates to serine proteases cloned from Bacillus gibsonii, and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.
    Type: Application
    Filed: December 4, 2019
    Publication date: August 6, 2020
    Inventors: MARC KOLKMAN, FRITS GOEDEGEBUUR, LILIA MARIA BABE, RIE MEJLDAL, HARM MULDER, ANJA HEMMINGSEN KELLETT-SMITH, RICHARD R BOTT, MILES CHRISTOPHER SCOTCHER
  • Publication number: 20200239814
    Abstract: The present disclosure relates to serine proteases cloned from Bacillus spp., and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.
    Type: Application
    Filed: November 7, 2019
    Publication date: July 30, 2020
    Inventors: Marc Kolkman, Anja Hemmingsen Kellett-Smith, Rie Mejldal, Lilia Maria Babe
  • Patent number: 10696958
    Abstract: Aspects of the present compositions and methods relate to novel metalloproteases, polynucleotides encoding the novel metalloproteases, and compositions and methods for use thereof.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: June 30, 2020
    Assignee: DANISCO US INC
    Inventors: Lilia M. Babe, Frits Goedegebuur, Roopa Ghirnikar, Xiaogang Gu, Marc Kolkman, Jian Yao