Abstract: The present invention concerns an automated substance preparation method comprising:—providing a first substance container containing a first substance;—a step of sampling to extract at least one portion of the first substance;—determination of a mass of the extracted at least one portion of the first substance;—encapsulating, in a first capsule, the extracted at least one portion of the first substance; and—repeating the step of sampling, mass determination and encapsulating to form a plurality of first capsules of the first substance having randomly distributed different masses of the first substance.

Abstract: The present invention relates to medical uses comprising the administration of anti-human CCR8 antibodies in specifically defined dosage regimens in monotherapy or combination therapy with an anti-PD-(L)1 antibody. The dosing schemes were developed for anti-human/cynomolgus CCR8 antibody TPP-23411, but they can also be used for other antibodies having similar properties as TPP-23411. The medical uses or dosage regimens may comprise a stratification step to select patients with an increased probability of treatment success. Suggested biomarkers are a) Tumor Proportion Score or Combined Positive Score as a measure for PD-(L)1 expression, b) analysing in a blood, plasma or serum sample inflammatory cytokines and c) previous treatment of the cancer for at least 6 months with an anti-PD-(L)1 antibody.

Abstract: A system for mounting electronic components on a substrate includes component holders each configured to hold an electronic components to be mounted on the substrate. A revolving device is configured to revolve the component holders along a pre-determined path so that each one of the component holders is moveable into a component receiving location for receiving a respective electronic component and/or a component mounting location for mounting the respective electronic component on the substrate. An actuator is configured to actuate a respective component holder in the component receiving location and/or the component mounting location. A safety device is configured to determine whether the respective component holder to be actuated by the actuator is properly placed in an operative position on the revolving device. The safety device is arranged separately from the actuator and is spaced apart from the actuator along the pre-determined path.

Abstract: A positioning device is adapted for positioning a tool at a setpoint position on a flat substrate in an X-Y plane, the tool exerting a process force in its axial direction perpendicularly onto the substrate. The tool includes a multicomponent force sensor to measure unwanted process-force components in the lateral direction. The setpoint position of the tool is correctable by the positioning device such that the lateral process-force components are minimized.

Abstract: A system for mounting electronic components on a substrate includes component holders each configured to hold an electronic components to be mounted on the substrate. A revolving device is configured to revolve the component holders along a pre-determined path so that each one of the component holders is moveable into a component receiving location for receiving a respective electronic component and/or a component mounting location for mounting the respective electronic component on the substrate. An actuator is configured to actuate a respective component holder in the component receiving location and/or the component mounting location. A safety device is configured to determine whether the respective component holder to be actuated by the actuator is properly placed in an operative position on the revolving device. The safety device is arranged separately from the actuator and is spaced apart from the actuator along the pre-determined path.

Abstract: A positioning device is adapted for positioning a tool at a setpoint position on a flat substrate in an X-Y plane, the tool exerting a process force in its axial direction perpendicularly onto the substrate. The tool includes a multicomponent force sensor to measure unwanted process-force components in the lateral direction. The setpoint position of the tool is correctable by the positioning device such that the lateral process-force components are minimized.