Abstract: There is provide an extended release dosage form comprising a release modifying excipient comprising high amylose starch, cross-linked hydroxypropylated amylopectin, and a pre-gelatinized common starch; wherein the release modifying excipient is substantially free of crosslinks between amylose and amylopectin and substantially free of crosslinks between amylose and amylose. It has been found that the extended release properties of conventional cross-linked high amylose starches (e.g., Contramid®) can be reproduced by intimately mixing i) cross-linked chemically modified amylopectin; ii) a high amylose, non-chemically modified starch and; iii) a pre-gelatinized common starch. Producing a release modifying excipient in this way means that no chemical cross linking between (a) amylose and amylopectin or (b) amylose and amylose has occurred—properties heretofore considered vital for Contramid® function.

Abstract: A system includes an input/output interface, a processor, and a non-transitory computer-readable medium having instructions stored thereon. The instructions, when executed, cause the processor to receive a fault code, display on the input/output interface a first component of an aircraft that is associated with the fault code, upon selection by a user of a first hyperlink associated with the first component, display a physical layout of the aircraft in which the first component is indicated, and upon selection by the user of a second hyperlink associated with the first component, display a first wiring diagram of the aircraft in which the first component is indicated.

Abstract: There is provide an extended release dosage form comprising a release modifying excipient comprising high amylose starch, cross-linked hydroxypropylated amylopectin, and a pre-gelatinized common starch; wherein the release modifying excipient is substantially free of crosslinks between amylose and amylopectin and substantially free of crosslinks between amylose and amylose. It has been found that the extended release properties of conventional cross-linked high amylose starches (e.g., Contramid®) can be reproduced by intimately mixing i) cross-linked chemically modified amylopectin; ii) a high amylose, non-chemically modified starch and; iii) a pre-gelatinized common starch. Producing a release modifying excipient in this way means that no chemical cross linking between (a) amylose and amylopectin or (b) amylose and amylose has occurred—properties heretofore considered vital for Contramid® function.

Abstract: There is provide an extended release dosage form comprising a release modifying excipient comprising high amylose starch, cross-linked hydroxypropylated amylopectin, and a pre-gelatinized common starch; wherein the release modifying excipient is substantially free of crosslinks between amylose and amylopectin and substantially free of crosslinks between amylose and amylose. It has been found that the extended release properties of conventional cross-linked high amylose starches (e.g., Contramid®) can be reproduced by intimately mixing i) cross-linked chemically modified amylopectin; ii) a high amylose, non-chemically modified starch and; iii) a pre-gelatinized common starch. Producing a release modifying excipient in this way means that no chemical cross linking between (a) amylose and amylopectin or (b) amylose and amylose has occurred—properties heretofore considered vital for Contramid® function.

Abstract: An example tiled display imaging system includes a frame and a plurality of tiles supported on the frame in a geometrical configuration for displaying a composite image. Each tile includes a display configured to display a respective portion of the composite image according to image data. Each tile further includes an acoustic coupling device coupled to the display, the acoustic coupling device configured to induce resonance in the display to generate an audio response at the tile according to audio data.

Abstract: There is provide an extended release dosage form comprising a release modifying excipient comprising high amylose starch, cross-linked hydroxypropylated amylopectin, and a pre-gelatinized common starch; wherein the release modifying excipient is substantially free of crosslinks between amylose and amylopectin and substantially free of crosslinks between amylose and amylose. It has been found that the extended release properties of conventional cross-linked high amylose starches (e.g., Contramid®) can be reproduced by intimately mixing i) cross-linked chemically modified amylopectin; ii) a high amylose, non-chemically modified starch and; iii) a pre-gelatinized common starch. Producing a release modifying excipient in this way means that no chemical cross linking between (a) amylose and amylopectin or (b) amylose and amylose has occurred—properties heretofore considered vital for Contramid® function.

Abstract: A system and method for pit design that that operates directly on a geological model without creating a three dimensional block model thereby minimizing modeling dilution. A resource in a deposit may be divided into a set of base resource units that closely conform to the resource geometry and value distribution and that can be mined by the equipment assumed to perform the excavation. A resource increment (RI) is defined by a base resource unit and any resource and waste over the base resource unit which is assumed to be excavated in conformance with slope stability and safe practices forming an approximation of a truncated inverted cone. A systematic sorting and grouping process of the RIs iterates down a list of RIs and identifies RIs and/or RI groups that add value to the pit while excluding RIs and/or RI groups that do not add value.

Abstract: A light emitting diode (LED) display is provided, including an array of LEDs comprising a first set of LEDs, and a second set of LEDs, alternating with the first set of LEDs, in a grid pattern. A driver drives the first and second set of LEDs according to, respectively, a first and second image. The display further includes a monolithic wire-grid polarizer, in front of the array, comprising first and second regions configured to respectively polarize light from the first and second set of LEDs, according to, respectively, a first linear polarization state and a second linear polarization state perpendicular to the first linear polarization state. The first and second regions are respectively aligned with the first and second sets of LEDs. A quarter-wave retarder is located in front of the wire-grid polarizer, for converting the first and second linear polarization states into respective circular polarization states.

Abstract: Amorphous solid dispersions suitable for oral delivery comprising fenretinide or an analog thereof and at least one matrix polymer, and processes for making the dispersions, are disclosed. Also disclosed are solid oral formulations comprising the amorphous solid dispersions, as well as uses thereof for the prevention and/or treatment of diseases or conditions treatable by fenretinide, including but not limited to cancers, conditions associated with a lipid imbalance, cystic fibrosis, osteoporosis, conditions associated with inflammation or opportunistic infections, and other diseases such as diabetes, obesity, dry-form age-related macular degeneration.

Abstract: Amorphous solid dispersions suitable for oral delivery comprising fenretinide or an analog thereof and at least one matrix polymer, and processes for making the dispersions, are disclosed. Also disclosed are solid oral formulations comprising the amorphous solid dispersions, as well as uses thereof for the prevention and/or treatment of diseases or conditions treatable by fenretinide, including but not limited to cancers, conditions associated with a lipid imbalance, cystic fibrosis, osteoporosis, conditions associated with inflammation or opportunistic infections, and other diseases such as diabetes, obesity, dry-form age-related macular degeneration.

Abstract: An LED display system having an LED module for reducing dark line defects. LED modules arranged adjacently in an LED display system form seams therebetween. An LED module for reducing dark line defects includes a set of imaging pixels for generating an image and a set of illuminating pixels for generating seam illumination through the seams. Seam illumination is directed through the seams directly or by a reflector integral with or attachable to the LED module or to a coupling assembly of the LED display system. The illuminating pixels may be controlled to track colour or intensity of the image being generated by imaging pixels.

Abstract: Amorphous solid dispersions suitable for oral delivery comprising fenretinide or an analog thereof and at least one matrix polymer, and processes for making the dispersions, are disclosed. Also disclosed are solid oral formulations comprising the amorphous solid dispersions, as well as uses thereof for the prevention and/or treatment of diseases or conditions treatable by fenretinide, including but not limited to cancers, conditions associated with a lipid imbalance, cystic fibrosis, osteoporosis, conditions associated with inflammation or opportunistic infections, and other diseases such as diabetes, obesity, dry-form age-related macular degeneration.

Abstract: A system includes an input/output interface, a processor, and a non-transitory computer-readable medium having instructions stored thereon. The instructions, when executed, cause the processor to receive a fault code, display on the input/output interface a first component of an aircraft that is associated with the fault code, upon selection by a user of a first hyperlink associated with the first component, display a physical layout of the aircraft in which the first component is indicated, and upon selection by the user of a second hyperlink associated with the first component, display a first wiring diagram of the aircraft in which the first component is indicated.

Abstract: An LED display system having an LED module for reducing dark line defects. LED modules arranged adjacently in an LED display system form seams therebetween. An LED module for reducing dark line defects includes a set of imaging pixels for generating an image and a set of illuminating pixels for generating seam illumination through the seams. Seam illumination is directed through the seams directly or by a reflector integral with or attachable to the LED module or to a coupling assembly of the LED display system. The illuminating pixels may be controlled to track colour or intensity of the image being generated by imaging pixels.

Abstract: Amorphous solid dispersions suitable for oral delivery comprising fenretinide or an analog thereof and at least one matrix polymer, and processes for making the dispersions, are disclosed. Also disclosed are solid oral formulations comprising the amorphous solid dispersions, as well as uses thereof for the prevention and/or treatment of diseases or conditions treatable by fenretinide, including but not limited to cancers, conditions associated with a lipid imbalance, cystic fibrosis, osteoporosis, conditions associated with inflammation or opportunistic infections, and other diseases such as diabetes, obesity, dry-form age-related macular degeneration.

Abstract: A system and method for pit design that that operates directly on a geological model without creating a three dimensional block model thereby minimizing modeling dilution. A resource in a deposit may be divided into a set of base resource units that closely conform to the resource geometry and value distribution and that can be mined by the equipment assumed to perform the excavation. A resource increment (RI) is defined by a base resource unit and any resource and waste over the base resource unit which is assumed to be excavated in conformance with slope stability and safe practices forming an approximation of a truncated inverted cone. A systematic sorting and grouping process of the RIs iterates down a list of RIs and identifies RIs and/or RI groups that add value to the pit while excluding RIs and/or RI groups that do not add value.

Abstract: A method of preparing a composite element for forming a composite assembly having a cavity is disclosed. The method includes laying a barrier layer on a surface of the composite element which defines at least part of the cavity. A support assembly including a mandrel (38) and a film bag (40) extending on the surface of the mandrel is positioned with the film bag against the barrier layer. A sealed enclosure containing the composite element is formed through sealing engagement with the film bag. The pressure within the sealed enclosure is reduced, and the mandrel is separated from the film bag while maintaining the film bag positioned against the barrier layer. In one embodiment, the element is a stringer and is positioned against a skin. An assembly for forming a composite member is also provided.

Abstract: A method, system and apparatus for dynamically monitoring and calibrating display tiles are provided. The apparatus comprises: an array of light emitting devices; one or more light emitting devices paired with light emitting devices of the array; one or more sensors configured to detect an optical characteristic and/or an electrical characteristic of the one or more paired light emitting devices; and, circuitry configured to: drive the array; drive each of the one or more further light emitting devices under same conditions as light emitting devices of the array; temporarily drive each of the one or more paired light emitting devices under different conditions from the array; and, adjust driving of the array based on the optical characteristic and/or electrical characteristic of the one or more paired light emitting devices detected at sensor(s) when the one or more paired light emitting devices are driven under the different conditions.

Abstract: A method, system and apparatus for dynamically monitoring and calibrating display tiles are provided. The apparatus comprises: an array of light emitting devices; one or more light emitting devices paired with light emitting devices of the array; one or more sensors configured to detect an optical characteristic and/or an electrical characteristic of the one or more paired light emitting devices; and, circuitry configured to: drive the array; drive each of the one or more further light emitting devices under same conditions as light emitting devices of the array; temporarily drive each of the one or more paired light emitting devices under different conditions from the array; and, adjust driving of the array based on the optical characteristic and/or electrical characteristic of the one or more paired light emitting devices detected at sensor(s) when the one or more paired light emitting devices are driven under the different conditions.

Abstract: A method, system and apparatus for dynamically monitoring and calibrating display tiles are provided. The apparatus comprises: an array of light emitting devices; one or more light emitting devices paired with light emitting devices of the array; one or more sensors configured to detect an optical characteristic and/or an electrical characteristic of the one or more paired light emitting devices; and, circuitry configured to: drive the array; drive each of the one or more further light emitting devices under same conditions as light emitting devices of the array; temporarily drive each of the one or more paired light emitting devices under different conditions from the array; and, adjust driving of the array based on the optical characteristic and/or electrical characteristic of the one or more paired light emitting devices detected at sensor(s) when the one or more paired light emitting devices are driven under the different conditions.