Abstract: The present invention relates to antibodies having specificity to Nectin-4 and uses thereof.

Abstract: The present invention relates to an antibody-drug conjugate comprising a monoclonal antibody or an antigen-binding fragment thereof wherein the monoclonal antibody or the antigen-binding fragment thereof binds to Nectin-4 and wherein the drug is an amatoxin, particularly ?-amanitin.

Abstract: The present invention relates to an antibody -drug conjugate comprising a monoclonal antibody or an antigen-binding fragment thereof wherein the monoclonal antibody or the antigen-binding fragment thereof binds to Nectin-4 and wherein the drug is a topoisomerase I inhibitor, particularly exatecan.

Abstract: The present invention relates to antibodies having specificity to Nectin-4 and uses thereof.

Abstract: The present invention relates to antibodies having specificity for Nectin-4 and uses thereof, in particular for the treatment of cancer.

Abstract: The present invention relates to a new antibody anti-nectin-4. Nectin-4 is a tumor-associated antigen overexpressed in several cancers and notably in 30%, 49% and 86% of breast, ovarian and lung carcinomas, respectively, which are tumors of bad prognosis. Treatments remain still elusive. That's why the inventors developed a new targeted therapy based on an antibody having specificity to nectin-4 (called 14A5.2 mab). Indeed, the inventors selected this antibody for its intrinsic prophylactic anti-metastatic properties and also for the treatment of localized primary and metastatic cancer. More, the 14A5.2 mab could be indicated for the treatment of cancer resistant to ASG-22ME (from Astellas company). Thus, the invention relates to the 14A5.2 mab and its uses thereof.

Abstract: A shunt tube entry device comprises one or more inlet ports, a shroud disposed at least partially about a wellbore tubular, and a shunt tube in fluid communication with the chamber. The shroud defines a chamber between the shroud and the wellbore tubular, and the chamber is in fluid communication with the one or more entry ports.

Abstract: This invention relates generally to apparatus and methods for tightening tissue of the female genitalia by heating targeted connective tissue with radiant energy, while cooling the mucosal epithelial surface over the target tissue to protect it from the heat. Embodiments include a handle and treatment tip that has both an energy delivery element and a cooling mechanism. The handle may be a two-handed handle allowing control even while rotating and maneuvering the treatment around the genital opening. The apparatus or system may also include an integrated controller, which may confirm tissue contact without applying RF energy, based only on the temperature of the applicator and the time since the last application of energy from the applicator.

Abstract: A downhole assembly is disclosed. The downhole assembly includes a tube disposed in a wellbore, and a shroud coupled to and disposed around the circumference of the tube to form an annulus between an inner surface of the shroud and an outer surface of the tube. The downhole assembly further includes a flow control device disposed in the annulus, and a degradable plug disposed in the annulus and positioned to prevent fluid flow between the annulus and the tube.

Abstract: This invention relates generally to apparatus and methods for tightening tissue of the female genitalia by heating targeted connective tissue with radiant energy, while cooling the mucosal epithelial surface over the target tissue to protect it from the heat. Embodiments include a handle and treatment tip that has both an energy delivery element and a cooling mechanism. The handle may be a two-handed handle allowing control even while rotating and maneuvering the treatment around the genital opening. The apparatus or system may also include an integrated controller, which may confirm tissue contact without applying RF energy, based only on the temperature of the applicator and the time since the last application of energy from the applicator.

Abstract: The present invention relates to a new antibody anti-nectin-4. Nectin-4 is a tumor-associated antigen overexpressed in several cancers and notably in 30%, 49% and 86% of breast, ovarian and lung carcinomas, respectively, which are tumors of bad prognosis. Treatments remain still elusive. That's why the inventors developed a new targeted therapy based on an antibody having specificity to nectin-4 (called 14A5.2 mab). Indeed, the inventors selected this antibody for its intrinsic prophylactic anti-metastatic properties and also for the treatment of localized primary and metastatic cancer. More, the 14A5.2 mab could be indicated for the treatment of cancer resistant to ASG-22ME (from Astellas company). Thus, the invention relates to the 14A5.2 mab and its uses thereof.

Abstract: A well screen assembly residing in a well bore has a base pipe and a filtration screen carried on the base pipe. The screen is radially extended with force from fluid while maintaining the base pipe radially unextended.

Abstract: The present invention relates to antibodies having specificity to nectin-4 and uses thereof.

Abstract: A shunt tube entry device comprises one or more inlet ports, a shroud disposed at least partially about a wellbore tubular, and a shunt tube in fluid communication with the chamber. The shroud defines a chamber between the shroud and the wellbore tubular, and the chamber is in fluid communication with the one or more entry ports.

Abstract: A flow control device includes an annular inner shroud coupled to a work string that defines one or more flow ports therein, and an annular outer shroud also coupled to the work string and radially offset from the inner shroud such that a channel is defined between at least a portion of the inner and outer shrouds. The channel is in fluid communication with at least one of the one or more flow ports and configured to restrict a flow rate of a fluid. The work string has a central axis and the inner and outer shrouds extend longitudinally within the work string.

Abstract: A shunt tube entry device comprises one or more inlet ports, a shroud disposed at least partially about a wellbore tubular, and a shunt tube in fluid communication with the chamber. The shroud defines a chamber between the shroud and the wellbore tubular, and the chamber is in fluid communication with the one or more entry ports.

Abstract: This invention relates generally to apparatus and methods for tightening tissue of the female genitalia by heating targeted connective tissue with radiant energy, while cooling the mucosal epithelial surface over the target tissue to protect it from the heat. Embodiments include a handle and treatment tip that has both an energy delivery element and a cooling mechanism. The handle may be a two-handed handle allowing control even while rotating and maneuvering the treatment around the genital opening. The apparatus or system may also include an integrated controller, which may confirm tissue contact without applying RF energy, based only on the temperature of the applicator and the time since the last application of energy from the applicator.

Abstract: Embodiments herein include an assembly comprising a base pipe having at least one flow port defined therein; a well screen arranged about the base pipe and in fluid communication with the at least one flow port, the well screen having an end disposed at or near the at least one flow port; a shroud arranged about the end of the well screen and extending axially along a length of the well screen; and an annular gap defined between the well screen and the shroud and configured to receive a flow of a fluid, wherein the shroud increases a flow resistance of the fluid by channeling the fluid across the annular gap to distribute a flow energy of the fluid over the length of the well screen.

Abstract: A downhole assembly is disclosed. The downhole assembly includes a tube disposed in a wellbore, and a shroud coupled to and disposed around the circumference of the tube to form an annulus between an inner surface of the shroud and an outer surface of the tube. The downhole assembly further includes a flow control device disposed in the annulus, and a degradable plug disposed in the annulus and positioned to prevent fluid flow between the annulus and the tube.

Abstract: This invention relates generally to apparatus and methods for tightening tissue of the female genitalia by heating targeted connective tissue with radiant energy, while cooling the mucosal epithelial surface over the target tissue to protect it from the heat. Embodiments include a handle and treatment tip that has both an energy delivery element and a cooling mechanism. The handle may be a two-handed handle allowing control even while rotating and maneuvering the treatment around the genital opening. The apparatus or system may also include an integrated controller, which may confirm tissue contact without applying RF energy, based only on the temperature of the applicator and the time since the last application of energy from the applicator.