Patents by Inventor Marc Mercken

Marc Mercken has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of binding amyloid beta protein having pyroglutamate at the third amino acid residue (3pE abeta) in vivo using anti-3pE abeta antibodies or antigen-binding fragments thereof
    Patent number: 11673943
    Abstract: The invention provides an antibody or antigen binding fragments thereof that binds to 3pE A? and methods of making and using the antibody or antigen binding fragment thereof, including use for formulations, administration and kits. The antibody and antigen binding fragments thereof and methods disclosed are useful for diagnosis, prognosis and treatment of Alzheimer's disease or other ?-amyloid-related diseases.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: June 13, 2023
    Assignee: Janssen Pharmaceutica NV
    Inventors: Marc Mercken, Bianca Van Broeck, Marc Vandermeeren, Bart Hermans, Astrid Bottelbergs
  • ANTI-PHF-TAU ANTIBODIES AND USES THEREOF
    Publication number: 20230151083
    Abstract: Monoclonal anti-PHF-tau antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies and using the antibodies for treating or preventing conditions such as tauopathies.
    Type: Application
    Filed: April 7, 2021
    Publication date: May 18, 2023
    Inventors: Kristof Van Kolen, Marc Mercken, Rupesh Nanjunda, Sanjaya Singh, Sherry La Porte, Jinquan Luo, Pharavee Jaiprasart, Sathya Venkataramani, Rajkumar Ganesan
  • Anti-PHF-Tau Antibodies and Uses Thereof
    Publication number: 20230047413
    Abstract: Monoclonal anti-PHF-tau antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and use of the antibodies for treating or preventing conditions such as tauopathies.
    Type: Application
    Filed: May 18, 2022
    Publication date: February 16, 2023
    Inventors: Marc Mercken, Thomas Malia, Marianne Borgers, Kristof Van Kolen
  • Anti-PHF-tau antibodies and uses thereof
    Patent number: 11365244
    Abstract: Monoclonal anti-PHF-tau antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies and using the antibodies for treating or preventing conditions such as tauopathies.
    Type: Grant
    Filed: August 6, 2020
    Date of Patent: June 21, 2022
    Assignee: Janssen Biotech, Inc.
    Inventors: Marc Mercken, Thomas Malia, Marianne Borgers, Kristof Van Kolen
  • Antibodies to Pyroglutamate Amyloid-B and Uses Thereof
    Publication number: 20220177560
    Abstract: The invention provides antibodies or antigen binding fragments thereof that bind to 3pE A? and methods of making and using the antibodies or antigen binding fragments thereof, including use for formulations, administration and kits. The antibody and antigen binding fragments thereof and methods disclosed are useful for diagnosis, prognosis and treatment of Alzheimer's disease or other ?-amyloid-related diseases.
    Type: Application
    Filed: March 25, 2020
    Publication date: June 9, 2022
    Inventors: Bianca Van Broeck, Marc Mercken, Wilson Edwards, Sanjaya Singh, Jinquan Luo, Sherry La Porte, Rajkumar Ganesan, Chichi Huang
  • ANTIBODIES TO PYROGLUTAMATE AMYLOID-B AND USES THEREOF
    Publication number: 20220106387
    Abstract: The invention provides antibodies or antigen binding fragments thereof that bind to 3pE A? and methods of making and using the antibodies or antigen binding fragments thereof, including use for formulations, administration and kits. The antibody and antigen binding fragments thereof and methods disclosed are useful for diagnosis, prognosis and treatment of Alzheimer's disease or other ?-amyloid-related diseases.
    Type: Application
    Filed: December 17, 2021
    Publication date: April 7, 2022
    Inventors: Bianca Van Broeck, Marc Mercken, Wilson Edwards, Sanjaya Singh, Jinquan Luo, Sherry La Porte, Rajkumar Ganesan, Chichi Huang
  • Antibodies to pyroglutamate amyloid-? and uses thereof
    Patent number: 11236155
    Abstract: The invention provides antibodies or antigen binding fragments thereof that bind to 3pE A? and methods of making and using the antibodies or antigen binding fragments thereof, including use for formulations, administration and kits. The antibody and antigen binding fragments thereof and methods disclosed are useful for diagnosis, prognosis and treatment of Alzheimer's disease or other ?-amyloid-related diseases.
    Type: Grant
    Filed: March 25, 2020
    Date of Patent: February 1, 2022
    Assignee: Janssen Pharmaceutica NV
    Inventors: Bianca Van Broeck, Marc Mercken, Wilson Edwards, Sanjaya Singh, Jinquan Luo, Sherry La Porte, Rajkumar Ganesan, Chichi Huang
  • Anti-PHF-Tau Antibodies and Uses Thereof
    Publication number: 20210179696
    Abstract: Monoclonal anti-PHF-tau antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies and using the antibodies for treating or preventing conditions such as tauopathies.
    Type: Application
    Filed: August 6, 2020
    Publication date: June 17, 2021
    Inventors: Marc Mercken, Thomas Malia, Marianne Borgers, Kristof Van Kolen
  • Antibodies to Pyroglutamate Amyloid-β and Uses Thereof
    Publication number: 20210147528
    Abstract: The invention provides an antibody or antigen binding fragments thereof that binds to 3pE A? and methods of making and using the antibody or antigen binding fragment thereof, including use for formulations, administration and kits. The antibody and antigen binding fragments thereof and methods disclosed are useful for diagnosis, prognosis and treatment of Alzheimer's disease or other ?-amyloid-related diseases.
    Type: Application
    Filed: November 25, 2020
    Publication date: May 20, 2021
    Applicant: Janssen Pharmaceutica NV
    Inventors: Marc Mercken, Bianca Van Broeck, Marc Vandermeeren, Bart Hermans, Astrid Bottelbergs
  • ANTI-PHF-TAU ANTIBODIES AND USES THEREOF
    Publication number: 20210002358
    Abstract: Monoclonal anti-tau antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies and using the antibodies for treating or preventing conditions such as tauopathies. The antibodies of the invention may also be used to quantify tau in biological samples.
    Type: Application
    Filed: March 4, 2019
    Publication date: January 7, 2021
    Inventors: Kristof Van Kolen, Marc Mercken, Linda Barone, Eilyn R. Lacy, Rupesh Nanjunda, John Wheeler, Jinquan Luo, Marianne Borgers
  • Methods of detecting pyroglutamate amyloid beta protein (3pE A?) using anti-3pE A? antibodies
    Patent number: 10851156
    Abstract: The invention provides an antibody or antigen binding fragments thereof that binds to 3pE A? and methods of making and using the antibody or antigen binding fragment thereof, including use for formulations, administration and kits. The antibody and antigen binding fragments thereof and methods disclosed are useful for diagnosis, prognosis and treatment of Alzheimer's disease or other ?-amyloid-related diseases.
    Type: Grant
    Filed: November 19, 2019
    Date of Patent: December 1, 2020
    Assignee: Janssen Pharmaceutica NV
    Inventors: Marc Mercken, Bianca Van Broeck, Marc Vandermeeren, Bart Hermans, Astrid Bottelbergs
  • Antibodies to Pyroglutamate Amyloid-B and Uses Thereof
    Publication number: 20200308261
    Abstract: The invention provides antibodies or antigen binding fragments thereof that bind to 3pE A? and methods of making and using the antibodies or antigen binding fragments thereof, including use for formulations, administration and kits. The antibody and antigen binding fragments thereof and methods disclosed are useful for diagnosis, prognosis and treatment of Alzheimer's disease or other ?-amyloid-related diseases.
    Type: Application
    Filed: March 25, 2020
    Publication date: October 1, 2020
    Inventors: Bianca Van Broeck, Marc Mercken, Wilson Edwards, Sanjaya Singh, Jinquan Luo, Sherry La Porte, Rajkumar Ganesan, Chichi Huang
  • Anti-PHF-tau antibodies and uses thereof
    Patent number: 10766953
    Abstract: Monoclonal anti-PHF-tau antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies and using the antibodies for treating or preventing conditions such as tauopathies.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: September 8, 2020
    Assignee: Janssen Biotech, Inc.
    Inventors: Marc Mercken, Thomas Malia, Marianne Borgers, Kristof Van Kolen
  • Antibodies to Pyroglutamate Amyloid-B and Uses Thereof
    Publication number: 20200165328
    Abstract: The invention provides an antibody or antigen binding fragments thereof that binds to 3pE A? and methods of making and using the antibody or antigen binding fragment thereof, including use for formulations, administration and kits. The antibody and antigen binding fragments thereof and methods disclosed are useful for diagnosis, prognosis and treatment of Alzheimer's disease or other ?-amyloid-related diseases.
    Type: Application
    Filed: November 19, 2019
    Publication date: May 28, 2020
    Applicant: JANSSEN PHARMACEUTICA NV
    Inventors: Marc Mercken, Bianca Van Broeck, Marc Vandermeeren, Bart Hermans, Astrid Bottelbergs
  • Anti-PHF-tau antibodies and uses thereof
    Patent number: 10633435
    Abstract: Monoclonal anti-tau antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies and using the antibodies for treating or preventing conditions such as tauopathies. The antibodies of the invention may also be used to quantify tau in biological samples.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: April 28, 2020
    Assignee: JANSSEN PHARMACEUTICA NV
    Inventors: Kristof Van Kolen, Marc Mercken, Linda Barone, Eilyn R. Lacy, Rupesh Nanjunda, John Wheeler, Jinquan Luo
  • Antibodies to pyroglutamate amyloid-? and uses thereof
    Patent number: 10519223
    Abstract: The invention provides an antibody or antigen binding fragments thereof that binds to 3pE A? and methods of making and using the antibody or antigen binding fragment thereof, including use for formulations, administration and kits. The antibody and antigen binding fragments thereof and methods disclosed are useful for diagnosis, prognosis and treatment of Alzheimer's disease or other ?-amyloid-related diseases.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: December 31, 2019
    Assignee: Jannsen Pharmaceutica NV
    Inventors: Marc Mercken, Bianca Van Broeck, Marc Vandermeeren, Bart Hermans, Astrid Bottelbergs
  • Anti-PHF-Tau Antibodies and Uses Thereof
    Publication number: 20190270793
    Abstract: Monoclonal anti-tau antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies and using the antibodies for treating or preventing conditions such as tauopathies. The antibodies of the invention may also be used to quantify tau in biological samples.
    Type: Application
    Filed: March 4, 2019
    Publication date: September 5, 2019
    Inventors: Kristof Van Kolen, Marc Mercken, Linda Barone, Eilyn R. Lacy, Rupesh Nanjunda, John Wheeler, Jinquan Luo
  • Anti-PHG-tau antibodies and their uses
    Patent number: 10196440
    Abstract: The present invention relates to anti-PHF-tau antibodies and methods of making and using them.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: February 5, 2019
    Assignee: Janssen Biotech, Inc.
    Inventors: Christopher Alderfer, Dariusz Janecki, Xuesong Liu, Melissa Murdock, Sheng-Jiun Wu, Marc Mercken, Marc Vandermeeren, Thomas Malia
  • ANTI-PHF-TAU ANTIBODIES AND THEIR USES
    Publication number: 20180305445
    Abstract: The present invention relates to anti-PHF-tau antibodies and methods of making and using them.
    Type: Application
    Filed: May 21, 2018
    Publication date: October 25, 2018
    Inventors: Christopher Alderfer, Dariusz Janecki, Xuesong Liu, Melissa Murdock, Sheng-Jiun Wu, Marc Mercken, Marc Vandermeeren, Thomas Malia
  • ANTI-PHF-TAU ANTIBODIES AND USES THEREOF
    Publication number: 20180265575
    Abstract: Monoclonal anti-PHF-tau antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies and using the antibodies for treating or preventing conditions such as tauopathies.
    Type: Application
    Filed: March 16, 2018
    Publication date: September 20, 2018
    Inventors: Marc Mercken, Thomas Malia, Marianne Borgers, Kristof Van Kolen