Abstract: The invention relates to a method for dosing a target component (20), wherein a dosing system (10) doses the target component (20) to a target value (Z20), which corresponds to a desired nominal value (S20soll), wherein an additional dosing system (12) doses at least one additional component (21, 22, 23) to be follow-on dosed, to a target value (Z21) of the component (21, 22, 23) to be follow-on dosed which is lower than a desired nominal value (S21soll) of the component (21, 22, 23) to be follow-on dosed, wherein an actual value (G20ist) of the target component (20) and at least one actual value (G21ist) of the component (21, 22, 23) to be follow-on dosed are then determined, a content (A) of the target component (20) then being calculated according to the actual value (G20ist) of the target component (20) and/or the actual value (G21ist) of the component (21, 22, 23) to be follow-on dosed and the content (A) being compared to a limit value (T) or tolerance band (T), at least the component (21, 22, 23) to be

Abstract: A method and apparatus (100) for recognizing a fault state of a machine (102) or of a process is disclosed. The apparatus (100) is configured to detect actual values of parameters of the process at the machine (102) for carrying out the process. The parameters include at least one controllable process parameter (204) of the process, at least one non-controllable process parameter (206) of the process or at least one control parameter (202) for controlling the or another controllable process parameter (204) in the process. The apparatus (100) is configured to predefine a target correlation for actual values of at least two of the parameters, to determine an actual correlation depending on the actual values of the at least two of the parameters, and to recognize a fault state of the machine (102) or of the process depending on the actual correlation and the target correlation.

Abstract: A production module for producing solid medicaments in individual batches, comprising a supplying device for supplying powdered starting materials, a mixing device connected to the feeding device and is intended for working the supplied powdered starting materials into a product, a final working device connected to the mixing device and is intended for the final production of an end product from the worked starting materials, and a control device for automatically controlling the supplying device and the mixing device and the final working device. Diverters allow a batch to be passed on from the supplying device to the mixing device and from the mixing device to the final working device without any backmixing. Data of all the process sensors and quality sensors of the production module are linked with the respective batch by the control device such that tracking and tracing of the batches is made possible.

Abstract: The invention relates to a method for dosing a target component (20), wherein a dosing system (10) doses the target component (20) to a target value (Z20), which corresponds to a desired nominal value (S20soll), wherein an additional dosing system (12) doses at least one additional component (21, 22, 23) to be follow-on dosed, to a target value (Z21) of the component (21, 22, 23) to be follow-on dosed which is lower than a desired nominal value (S21soll) of the component (21, 22, 23) to be follow-on dosed, wherein an actual value (G20ist) of the target component (20) and at least one actual value (G21ist) of the component (21, 22, 23) to be follow-on dosed are then determined, a content (A) of the target component (20) then being calculated according to the actual value (G20ist) of the target component (20) and/or the actual value (G21ist) of the component (21, 22, 23) to be follow-on dosed and the content (A) being compared to a limit value (T) or tolerance band (T), at least the component (21, 22, 23) to be

Abstract: The invention relates to a fluidised bed system (1) comprising a plurality of granulation units (2), arranged so as to be functionally parallel, for producing pharmaceutical granules, each granulation unit (2) comprising: a fluidised bed container (3), an inlet (4) and an outlet (5) on said fluidised bed container (3), a fluid supply (6) and a fluid discharge (7) on said fluidised bed container (3), and at least one injection nozzle (8) for injecting a processing substance into the fluidised bed container (3), as well as a control unit for adjusting processing conditions within each granulation unit (2).

Abstract: The present invention relates to a production module (1) for producing solid medicaments (22) in individual batches (37, 38, 39, 40), comprising a supplying device (2) for supplying powdered starting materials, a mixing device (3), which is connected to the feeding device (2) and is intended for working the supplied powdered starting materials into a product, a final working device (4), which is connected to the mixing device (3) and is intended for the final production of an end product from the worked starting materials, and a control device (5) for automatically controlling the supplying device (2) and the mixing device (3) and the final working device (4), characterized in that diverters (6, 7, 9, 12) allow a batch (37, 38, 39, 40) to be passed on from the supplying device (2) to the mixing device (3) and from the mixing device (3) to the final working device (4) without any backmixing, and in that data of all the process sensors and quality sensors of the production module (1) are linked with the respect

Abstract: The invention relates to a fluidised bed system (1) comprising a plurality of granulation units (2), arranged so as to be functionally parallel, for producing pharmaceutical granules, each granulation unit (2) comprising: a fluidised bed container (3), an inlet (4) and an outlet (5) on said fluidised bed container (3), a fluid supply (6) and a fluid discharge (7) on said fluidised bed container (3), and at least one injection nozzle (8) for injecting a processing substance into the fluidised bed container (3), as well as a control unit for adjusting processing conditions within each granulation unit (2).

Abstract: The invention relates to a method for connecting at least two sheet metal parts (1, 5), wherein an impressing/press-insertion element is fastened to the first sheet metal part (1) and then the impressing/press-insertion element (3) fastened to the first sheet metal part (1) is welded to the second sheet metal part (5), in particular by spot welding. According to the invention, in order to fasten the impressing/press-insertion element to the first sheet metal part (1), the impressing/press-insertion element (3) is pressed into the material of the first sheet metal part (1) in a deep-drawing direction (T) in a deep-drawing process and enters into a form-locked connection to the first sheet metal part (1) under plastic deformation.