Abstract: The invention relates to a 1-aza-bicyclo [2.2.2] oct-2-en-3-ylmethyl acetate of the formula (I), wherein said compound is useful as a synthesis intermediate for the production of mequitazine.

Abstract: The present invention relates to a method for synthesizing a pharmaceutically acceptable acid addition salt of (1S, 2R)-milnacipran comprising the following successive steps: (a) reaction of phenylacetonitrile and of (R)-epichlorhydrin in the presence of a base containing an alkaline metal, followed by a basic treatment, and then by an acid treatment in order to obtain a lactone; (b) reaction of said lactone with MNEt2, wherein M represents an alkaline metal, or with NHEt2 in the presence of a Lewis acid-amine complex, in order to obtain an amide-alcohol; (c) reaction of said amide-alcohol with thionyl chloride in order to obtain a chlorinated amide; (d) reaction of said chlorinated amide with a phthalimide salt in order to obtain a phthalimide derivative; (e) hydrolysis of the phthalimide group of said phthalimide derivative in order to obtain (1S, 2R)-milnacipran, and (f) salification of (1S, 2R)-milnacipran in a suitable solvent system in the presence of a pharmaceutically acceptable acid.

Abstract: The invention relates to a 1-aza-bicyclo[2.2.2]oct-2-en-3-ylmethyl acetate of the formula (I), wherein said compound is useful as a synthesis intermediate for the production of mequitazine.

Abstract: The invention relates to a can end for a can, such as an easy opening can, comprising: a central panel; a can end radius for connection to a body of the can; and a countersink connected via a transition wall to the can end radius and via a panel wall to the panel; wherein a panel wall angle is 2°-45°; a panel radius is larger than 0.5 mm; a panel depth is 1 mm-7 mm; and a countersink radius is less than 5 mm; and to cans provided with at least one such a can end.

Abstract: Described are heterobicyclic compounds such as 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]thiopyran 3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid amides, or benzo[b]thiophene-3-carboxylic acid amides and pharmaceutically acceptable salts thereof, the use of these derivatives for the prophylaxis and/or treatment of various diseases such as infectious diseases, including mycobacteriainduced infections and opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, as well as compositions containing at least one heterobicyclic compound and/or pharmaceutically acceptable salts thereof. Furthermore, reaction procedures for the synthesis of the heterobicyclic compound are disclosed.

Abstract: An assembly comprising at least one device remotely controlled by at least one transmitter (ESA, ESB) possessing an identity number capable of transmitting a signal consisting of a frame containing the identity number (A, B) and a command and a receiver (R1, R2) which are associated with the remotely controlled device (VR1, VR2) and capable of extracting the identity number from the signal received and of storing it. At least one transmitter of the assembly is a transmitter of simple type, that is to say whose signal frame contains an identifier signifying that this transmitter may control only a single receiver and the program contained in the processor of at least one receiver contains a routine for testing and identifying the type of transmitter preventing the recording of additional transmitter identity numbers in the memory if the identity number identified is that of a transmitter of simple type. A transmitter can then control only a single receiver.

Abstract: Process for the preparation of cericlamine which consists: i) in arylating methacrylic acid with the diazonium chloride of 3,4-dichloroaniline, to obtain (+/-)2-chloro-3-(3,4-dichlorophenyl)-2-methylpropionic acid, ii) in aminating the acid with dimethylamine, to obtain (+/-)3-(3,4-dichlorophenyl)-2-dimethylamino-2-methylpropionic acid, or an alkaline metal salt thereof, iii) in esterifying the amino-acid or its salt, then, iv) in reducing the ester by a metal or organometal hydride to obtain (+/-)3-(3,4-dichlorophenyl)-2-dimethylamino-2-methyl-propan-1-ol.

Abstract: Method for producing a shaped part made of a graphitized carbon/carbon composite material in which a compound of carbon fibers is prepared impregnated with a solution of carbon precursors and then cut into sections placed in a mould subjected to a carbonization stage by means of hot unidirectional pressing, wherein, so as to prepare the compound, the fiber is subjected to a heat deoxidation and oil removal treatment followed by a softening in a bath for increasing wettability and hooking and then impregnation in a bath formed of an aqueous solution containing pitch mesophase, high-yield pitch and a binder, the required sufficient calculated amount of compound being placed in bulk in a hot constant volume pressing mould so as to accurately fill the mould at the end of pressing before carrying out said carbonization, the moulded part finally being graphitized at a high temperature. Applications include the aeronautic and spatial fields.