Abstract: The invention relates to novel pharmaceutical compositions comprising 2-isoxazole-8-aminotetralin derivatives. The invention more specifically relates to compositions in the form of a patch comprising a therapeutically efficacious amount of a derivative of 2-isoxazole-8-aminotetraline, especially 1,2,3,4-tetrahydro-8(5-isoxazolyl)N-N-diisopropyl-2-naphtalenamine. The invention also relates to a 2-isoxazole-8-aminotetralin derivative, especially 1,2,3,4-tetrahydro-8-(5-isoxazolyl)-N,N-diisopropyl-2-naphtalenamine, which is used to produce a medicament which can be administered transdermally to treat irritable bowel syndrome.

Abstract: Solid or semisolid pharmaceutical composition comprising a gellable and water-soluble peptide salt optionally combined with an appropriate excipient, said pharmaceutical composition being characterized in that the peptide salt has a high specific surface area and in that, once injected into a patient, it forms a gel in contact with this patient's body substances, said gel being capable of releasing the peptide over a prolonged period of at least 15 days.

Abstract: The invention relates to compositions in the form of microcapsules or implants comprising a biodegradable polymeric or copolymeric excipient or a mixture of such excipients with an inherent viscosity of between 0.5 dl/g and 1.6 dl/g in CHCl3, and one active substance or a mixture of active substances, it being possible for said microcapsules or implants to release the active substance or mixture of active substances over a prolonged period of up to three months or more. These compositions may also comprise an active principle having a high specific surface area.

Abstract: The invention relates to compositions in the form of microcapsules or implants comprising a biodegradable polymeric or copolymeric excipient or a mixture of such excipients with an inherent viscosity of between 0.5 dl/g and 1.6 dl/g in CHCl3, and one active substance or a mixture of active substances, it being possible for said microcapsules or implants to release the active substance or mixture of active substances over a prolonged period of up to three months or more. These compositions may also comprise an active principle having a high specific surface area.

Abstract: A method of manufacturing an enclosure containing hot gases cooled by transpiration comprises:forming a shaped rigid shell comprised of a microperforated sheet metal, hydraulic calibration sheath,welding spacers to an outside face of the hydraulic calibration sheath;welding an outer sealing envelope on an outside surface of the spacers and the partitions; andforming a porous wall by applying a deposit onto an inside face of the hydraulic calibration sheath.

Abstract: An enclosure containing hot gases cooled by transpiration includes means for applying a cooling fluid, said means comprising a hydraulic calibration sheath applied on the outside face of a porous wall that forms the inside portion of the enclosure, said sheath being made of a material that is proof to the cooling liquid and that is perforated by a multiplicity of microperforations having a distribution density that varies progressively over various different portions of said wall so as to provide greater perforation density wherever the heat flow to be cooled reaching the porous wall is high, and a cooling fluid feed volume formed between the sheath secured to the porous wall and an outer sealing envelope so as to apply a pre-determined flow rate per unit of area to said sheath in various different zones of the wall of the enclosure, spacers being interposed between the hydraulic calibration sheath and the outer sealing envelope.