Patents by Inventor Marc Prindle
Marc Prindle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250115895Abstract: Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.Type: ApplicationFiled: May 28, 2024Publication date: April 10, 2025Inventors: Mark Stamatios Kokoris, Marc Prindle, Melud Nabavi, Craig Ostrander, Taylor Lehmann, Samantha Vellucci, Michael Kovarik, Jack Chase, Robert Busam, Miranda Lahman
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Publication number: 20250002899Abstract: Methods and compositions for the selection of nucleic acid processing and other enzymes, and more specifically for the selection of DNA polymerases and other enzymes with desired properties employing the directed evolution of enzymes by plasmid tagging in droplets.Type: ApplicationFiled: September 5, 2024Publication date: January 2, 2025Inventors: Mark Stamatios Kokoris, Michael Kovarik, Marc Prindle, Salka Keller, Robert Busam, Miranda Lahman
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Patent number: 12116570Abstract: Methods and compositions for the selection of nucleic acid processing and other enzymes, and more specifically for the selection of DNA polymerases and other enzymes with desired properties employing the directed evolution of enzymes by plasmid tagging in droplets.Type: GrantFiled: September 28, 2017Date of Patent: October 15, 2024Assignee: Roche Sequencing Solutions, Inc.Inventors: Mark Stamatios Kokoris, Michael Kovarik, Marc Prindle, Salka Keller, Robert Busam, Miranda Lahman
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Publication number: 20240240161Abstract: Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.Type: ApplicationFiled: June 2, 2023Publication date: July 18, 2024Inventors: Mark Stamatios Kokoris, Marc Prindle, Jack Chase, Robert Busam, Michael Kovarik, Salka Keller, Megan Murt, Greg Thiessen
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Patent number: 12037577Abstract: Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.Type: GrantFiled: March 3, 2022Date of Patent: July 16, 2024Assignee: Roche Sequencing Solutions, Inc.Inventors: Mark Stamatios Kokoris, Marc Prindle, Melud Nabavi, Craig Ostrander, Taylor Lehmann, Samantha Vellucci, Michael Kovarik, Jack Chase, Robert Busam, Miranda Lahman
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Publication number: 20230313157Abstract: Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and accurate incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.Type: ApplicationFiled: November 16, 2022Publication date: October 5, 2023Inventors: Mark Kokoris, Marc Prindle, Gregory Scott Thiessen, Alexander Isaac Lehmann, Drew Goodman, Aaron Jacobs, John Chase
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Patent number: 11708566Abstract: Recombinant DP04-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DP04 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.Type: GrantFiled: May 3, 2018Date of Patent: July 25, 2023Assignee: Stratos Genomics, Inc.Inventors: Mark Stamatios Kokoris, Marc Prindle, Jack Chase, Robert Busam, Michael Kovarik, Salka Keller, Megan Murt, Greg Thiessen
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Patent number: 11530392Abstract: Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and accurate incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.Type: GrantFiled: December 10, 2018Date of Patent: December 20, 2022Assignee: Stratos Genomics, Inc.Inventors: Mark Kokoris, Marc Prindle, Gregory Scott Thiessen, Alexander Isaac Lehmann, Drew Goodman, Aaron Jacobs, John Chase
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Publication number: 20220186205Abstract: Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.Type: ApplicationFiled: March 3, 2022Publication date: June 16, 2022Inventors: Mark Stamatios Kokoris, Marc Prindle, Melud Nabavi, Craig Ostrander, Taylor Lehmann, Samantha Vellucci, Michael Kovarik, Jack Chase, Robert Busam, Miranda Lahman
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Patent number: 11299725Abstract: Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.Type: GrantFiled: May 4, 2020Date of Patent: April 12, 2022Assignee: Stratos Genomics, Inc.Inventors: Mark Stamatios Kokoris, Marc Prindle, Melud Nabavi, Craig Ostrander, Taylor Lehmann, Samantha Vellucci, Michael Kovarik, Jack Chase, Robert Busam, Miranda Lahman
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Publication number: 20220042075Abstract: Methods, compositions and devices for single molecule sequencing are provided, particularly for solid-state synthesis and processing of expandable polymers (e.g., Xpandomers), as well as methods and compositions for producing new expandable polymer constructs that provide more accurate sequence information when passed through a nanopore sensor.Type: ApplicationFiled: August 17, 2021Publication date: February 10, 2022Inventors: Lacey Merrill, Marc Prindle, Samantha Vellucci, Jagadeeswaran Chandrasekar, Mark Stamatios Kokoris, Gerson Aguirre, John Tabone, Robert N. McRuer, Michael Lee, Matthew Corning, Greg Thiessen, Salka Keller Barrett, Christian Berrios, Aaron Jacobs, Taylor Lehmann
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Publication number: 20210163903Abstract: Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and accurate incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.Type: ApplicationFiled: December 10, 2018Publication date: June 3, 2021Inventors: Mark KOKORIS, Marc PRINDLE, Gregory Scott Thiessen, Alexander Isaac LEHMANN, Drew GOODMAN, Aaron JACOBS, John CHASE
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Publication number: 20210108183Abstract: Recombinant DP04-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DP04 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.Type: ApplicationFiled: May 3, 2018Publication date: April 15, 2021Inventors: Mark Stamatios Kokoris, Marc Prindle, Jack Chase, Robert Busam, Michael Kovarik, Salka Keller, Megan Murt, Greg Thiessen
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Publication number: 20200385701Abstract: Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.Type: ApplicationFiled: May 4, 2020Publication date: December 10, 2020Inventors: Mark Stamatios Kokoris, Marc Prindle, Melud Nabavi, Craig Ostrander, Taylor Lehmann, Samantha Vellucci, Michael Kovarik, Jack Chase, Robert Busam, Miranda Lahman
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Patent number: 10745685Abstract: Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.Type: GrantFiled: November 11, 2016Date of Patent: August 18, 2020Assignee: Stratos Genomics, Inc.Inventors: Mark Stamatios Kokoris, Marc Prindle, Melud Nabavi, Craig Ostrander, Taylor Lehmann, Samantha Vellucci, Michael Kovarik, Jack Chase, Robert Busam, Miranda Lahman
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Publication number: 20200032247Abstract: Methods and compositions for the selection of nucleic acid processing and other enzymes, and more specifically for the selection of DNA polymerases and other enzymes with desired properties employing the directed evolution of enzymes by plasmid tagging in droplets.Type: ApplicationFiled: September 28, 2017Publication date: January 30, 2020Inventors: Mark Stamatios KOKORISKokoris, Michael KOVARIK, Marc PRINDLE, Salka KELLER, Robert BUSAM, Miranda LAHAM
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Publication number: 20190078075Abstract: Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.Type: ApplicationFiled: November 11, 2016Publication date: March 14, 2019Inventors: Mark Stamatios Kokoris, Marc Prindle, Melud Nabavi, Craig Ostrander, Taylor Lehmann, Samantha Vellucci, Michael Kovarik, Jack Chase, Robert Busam, Miranda Lahman
