Patents by Inventor Marc Prindle

Marc Prindle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DP04 POLYMERASE VARIANTS WITH IMPROVED ACCURACY
    Publication number: 20230313157
    Abstract: Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and accurate incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.
    Type: Application
    Filed: November 16, 2022
    Publication date: October 5, 2023
    Inventors: Mark Kokoris, Marc Prindle, Gregory Scott Thiessen, Alexander Isaac Lehmann, Drew Goodman, Aaron Jacobs, John Chase
  • DP04 polymerase variants
    Patent number: 11708566
    Abstract: Recombinant DP04-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DP04 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: July 25, 2023
    Assignee: Stratos Genomics, Inc.
    Inventors: Mark Stamatios Kokoris, Marc Prindle, Jack Chase, Robert Busam, Michael Kovarik, Salka Keller, Megan Murt, Greg Thiessen
  • DPO4 polymerase variants with improved accuracy
    Patent number: 11530392
    Abstract: Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and accurate incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: December 20, 2022
    Assignee: Stratos Genomics, Inc.
    Inventors: Mark Kokoris, Marc Prindle, Gregory Scott Thiessen, Alexander Isaac Lehmann, Drew Goodman, Aaron Jacobs, John Chase
  • DPO4 POLYMERASE VARIANTS
    Publication number: 20220186205
    Abstract: Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.
    Type: Application
    Filed: March 3, 2022
    Publication date: June 16, 2022
    Inventors: Mark Stamatios Kokoris, Marc Prindle, Melud Nabavi, Craig Ostrander, Taylor Lehmann, Samantha Vellucci, Michael Kovarik, Jack Chase, Robert Busam, Miranda Lahman
  • DP04 polymerase variants
    Patent number: 11299725
    Abstract: Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: April 12, 2022
    Assignee: Stratos Genomics, Inc.
    Inventors: Mark Stamatios Kokoris, Marc Prindle, Melud Nabavi, Craig Ostrander, Taylor Lehmann, Samantha Vellucci, Michael Kovarik, Jack Chase, Robert Busam, Miranda Lahman
  • METHODS, COMPOSITIONS, AND DEVICES FOR SOLID-STATE SYNTEHSIS OF EXPANDABLE POLYMERS FO RUSE IN SINGLE MOLECULE SEQUENCINGS
    Publication number: 20220042075
    Abstract: Methods, compositions and devices for single molecule sequencing are provided, particularly for solid-state synthesis and processing of expandable polymers (e.g., Xpandomers), as well as methods and compositions for producing new expandable polymer constructs that provide more accurate sequence information when passed through a nanopore sensor.
    Type: Application
    Filed: August 17, 2021
    Publication date: February 10, 2022
    Inventors: Lacey Merrill, Marc Prindle, Samantha Vellucci, Jagadeeswaran Chandrasekar, Mark Stamatios Kokoris, Gerson Aguirre, John Tabone, Robert N. McRuer, Michael Lee, Matthew Corning, Greg Thiessen, Salka Keller Barrett, Christian Berrios, Aaron Jacobs, Taylor Lehmann
  • DPO4 POLYMERASE VARIANTS WITH IMPROVED ACCURACY
    Publication number: 20210163903
    Abstract: Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and accurate incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.
    Type: Application
    Filed: December 10, 2018
    Publication date: June 3, 2021
    Inventors: Mark KOKORIS, Marc PRINDLE, Gregory Scott Thiessen, Alexander Isaac LEHMANN, Drew GOODMAN, Aaron JACOBS, John CHASE
  • DP04 POLYMERASE VARIANTS
    Publication number: 20210108183
    Abstract: Recombinant DP04-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DP04 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.
    Type: Application
    Filed: May 3, 2018
    Publication date: April 15, 2021
    Inventors: Mark Stamatios Kokoris, Marc Prindle, Jack Chase, Robert Busam, Michael Kovarik, Salka Keller, Megan Murt, Greg Thiessen
  • DP04 POLYMERASE VARIANTS
    Publication number: 20200385701
    Abstract: Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.
    Type: Application
    Filed: May 4, 2020
    Publication date: December 10, 2020
    Inventors: Mark Stamatios Kokoris, Marc Prindle, Melud Nabavi, Craig Ostrander, Taylor Lehmann, Samantha Vellucci, Michael Kovarik, Jack Chase, Robert Busam, Miranda Lahman
  • DP04 polymerase variants
    Patent number: 10745685
    Abstract: Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: August 18, 2020
    Assignee: Stratos Genomics, Inc.
    Inventors: Mark Stamatios Kokoris, Marc Prindle, Melud Nabavi, Craig Ostrander, Taylor Lehmann, Samantha Vellucci, Michael Kovarik, Jack Chase, Robert Busam, Miranda Lahman
  • DIRECTED EVOLUTION OF ENZYMES BY PLASMID TAGGING IN DROPLETS
    Publication number: 20200032247
    Abstract: Methods and compositions for the selection of nucleic acid processing and other enzymes, and more specifically for the selection of DNA polymerases and other enzymes with desired properties employing the directed evolution of enzymes by plasmid tagging in droplets.
    Type: Application
    Filed: September 28, 2017
    Publication date: January 30, 2020
    Inventors: Mark Stamatios KOKORISKokoris, Michael KOVARIK, Marc PRINDLE, Salka KELLER, Robert BUSAM, Miranda LAHAM
  • DP04 POLYMERASE VARIANTS
    Publication number: 20190078075
    Abstract: Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.
    Type: Application
    Filed: November 11, 2016
    Publication date: March 14, 2019
    Inventors: Mark Stamatios Kokoris, Marc Prindle, Melud Nabavi, Craig Ostrander, Taylor Lehmann, Samantha Vellucci, Michael Kovarik, Jack Chase, Robert Busam, Miranda Lahman