Abstract: The present invention relates to a system for protecting medical personnel and/or a patient from airborne pathogens in a surgical environment and a method for protecting medical personnel and/or a patient from airborne pathogens in a surgical environment.

Abstract: The present invention relates to an anti-cancer delivery system with a delayed and sustained release of one or more chemotherapeutic agent(s), a mixture for use in the treatment of cancer comprising such a delivery system and a method for producing such a delivery system.

Abstract: The present invention relates to an active substance delivery system, preferably an anti-cancer agent delivery system, comprising one or more active substances included in nanoparticles and a method for producing such a delivery system.

Abstract: The present invention relates to a medical instrument for the targeted introduction of a substance into a body cavity and to a tool (1) therefor. According to the invention, the tool (1) has a shaft (2) with a lumen (6), on the distal end (1?) of which is situated a nozzle head (3) with at least two nozzles (4), wherein the nozzles (4) are spaced from each other at an angle of less than 180° and equally relative to a centre axis (M) of the shaft (2).

Abstract: The present invention relates to a medical instrument for the targeted introduction of a substance into a body cavity and to a tool (1) therefor. According to the invention, the tool (1) has a shaft (2) with a lumen (6), on the distal end (1?) of which is situated a nozzle head (3) with at least two nozzles (4), wherein the nozzles (4) are spaced from each other at an angle of less than 180° and equally relative to a centre axis (M) of the shaft (2).

Abstract: A surgical device and a method for using the surgical device are disclosed. In an embodiment the device for applying a substance (X) in a hollow space of a body cavity such as a hollow organ, in particular a therapeutic pneumoperitoneum, includes a trocar system with a trocar sleeve, the trocar system having a gas connection to which an insufflation gas-supply line can be connected and a nozzle system, which in its interior forms a lumen with a proximal end and a distal end, wherein the nozzle system has a needle nozzle fixed at the distal end of the lumen, and wherein the nozzle system is guided by the trocar sleeve.

Abstract: A device suitable for insertion into and for use within a tubular body cavity of a patient includes a first expandable fluid chamber for sealing a first section of the body cavity, an aerosol generating apparatus for generation of a therapeutic aerosol within a treatment section of the body cavity positioned adjacent to the first section, and an insufflation apparatus for insufflation of a gaseous medium into the treatment section of the body cavity.

Abstract: The present invention relates to a male fluid coupling to be pushed into a female coupling in order to form a fluidic coupling device with no dead volume able to transfer a fluid, and to such a device. The female coupling (102) is coupled to a first pipe (C1) communicating with a second pipe (C2) passing through the male coupling, this female coupling having an internal push-fitting surface (103) ending in a female end (104) at which the first pipe emerges, and male coupling comprises an external push-fitting surface (106) ending in a male end (107) intended to lie inside the female coupling.

Abstract: The invention relates to a device (1) for the directed application of a substance (X) in a hollow space (200), such as a hollow organ, of a body cavity, in particular a therapeutic pneumoperitoneum, comprising: a trocar system with a trocar sleeve (45), said trocar system (40) having a gas connection (43) to which an insufflation gas-supply line (81) can be connected, and a nozzle system (20), which in its interior forms a lumen (26), with a proximal end (21) and a distal end (22), wherein the nozzle system (20) has a needle nozzle (30) fixed at the distal end (22) with the lumen (26) and is guided by the trocar sleeve (45).

Abstract: A continuous automated extraction system and method for physically extracting at least one liquid phase of a series of liquid microsamples which are taken beforehand in discrete packets, both in space and in time, and are in stored is provided. The method may include an extraction system having a centrifuge provided with a plurality of microholders, at least one of which is filled with the corresponding microsample and includes a filling upper portion that is extended by a separating lower portion of smaller cross section than that of the upper portion. Each filled microholder has a mass which is more than ten times the mass of this microsample, in such a way that it is possible to extract, by centrifugation, at a given instant, only a single microsample contained in a single microholder, or several microsamples contained in some or all of these microholders, progressively as the latter are filled.

Abstract: The invention relates to a fluid connection device and to a continuous automated system and method for taking fluid microsamples using this device. A device (20) according to the invention, which is intended to be connected to a first line (21) via a first opening and includes a second opening through which a second line (28) passes, comprises: a female fluid connector (22) that defines the first opening and has an internal fitting surface (23) terminating in a female end (24) into which this first line opens; and a male fluid connector (25) that defines the second opening, which is fitted into the female connector via its external surface (26) and terminates via its male radial end (27) inside the female connector.

Abstract: The present invention relates to a male fluid coupling to be pushed into a female coupling in order to form a fluidic coupling device with no dead volume able to transfer a fluid, and to such a device. The female coupling (102) is coupled to a first pipe (C1) communicating with a second pipe (C2) passing through the male coupling, this female coupling having an internal push-fitting surface (103) ending in a female end (104) at which the first pipe emerges, and male coupling comprises an external push-fitting surface (106) ending in a male end (107) intended to lie inside the female coupling.

Abstract: The invention relates to a device and a method for counting elementary particles emitted by a fluid, the device comprising a line for transferring the fluid and, outside the line, detection means (6a) for detecting the particles that are attenuated by a wall of the line and/or by this fluid. A counting device according to the invention includes at least one counting portion (4a) of oblong cross section which joins together two adjacent portions of the line having a larger flow section and which has an [internal height (h)/internal width (l)] ratio of 20% or less, in which the internal height and the internal width represent the smallest and largest transverse dimensions respectively of the portion, these being measured along two approximately perpendicular directions, said detection means extending transversely to this portion, facing its entire internal width and on either side thereof.

Abstract: The invention relates to a device and a method for counting elementary particles emitted by a fluid, the device comprising a line for transferring the fluid and, outside the line, detection means (6a) for detecting the particles that are attenuated by a wall of the line and/or by this fluid. A counting device according to the invention includes at least one counting portion (4a) of oblong cross section which joins together two adjacent portions of the line having a larger flow section and which has an [internal height (h)/internal width (l)] ratio of 20% or less, in which the internal height and the internal width represent the smallest and largest transverse dimensions respectively of the portion, these being measured along two approximately perpendicular directions, said detection means extending transversely to this portion, facing its entire internal width and on either side thereof.

Abstract: The present invention relates in particular to a continuous automated extraction system and method for physically extracting at least one liquid phase of a series of liquid microsamples which are taken beforehand in discrete packets, both in space and in time, and are in stored. An extraction system (10) according to the invention comprises a centrifuge (13) provided with a plurality of microholders (12), at least one of which is filled with the corresponding microsample and includes a filling upper portion that is extended by a separating lower portion of smaller cross section than that of the upper portion. According to the invention, the or each holder thus filled has a mass which is more than ten times the mass of this microsample, in such a way that it is possible to extract, by centrifugation, at a given instant, only a single microsample contained in a single microholder, or several microsamples contained in some or all of these microholders, progressively as the latter are filled.

Abstract: The invention relates to a fluid connection device and to a continuous automated system and method for taking fluid microsamples using this device. A device (20) according to the invention, which is intended to be connected to a first line (21) via a first opening and includes a second opening through which a second line (28) passes, comprises: a female fluid connector (22) that defines the first opening and has an internal fitting surface (23) terminating in a female end (24) into which this first line opens; and a male fluid connector (25) that defines the second opening, which is fitted into the female connector via its external surface (26) and terminates via its male radial end (27) inside the female connector.

Abstract: The invention relates to compositions comprising caveolin polypeptides and nucleic acids, and methods of use thereof. The invention is useful in the treatment of non-steroid dependent carcinoma, especially for treatment of gastrointestinal carcinoma. According to the invention, caveolin-1 or the gene encoding caveolin are especially preferred to treat colon carcinoma.

Abstract: The invention relates to compositions comprising caveolin polypeptides and nucleic acids, and methods of use thereof. The invention is useful in the treatment of non-steroid dependent carcinoma, especially for treatment of gastrointestinal carcinoma. According to the invention, caveolin-1 or the gene encoding caveolin are especially preferred to treat colon carcinoma.

Abstract: A process for isomerising a feed comprising aromatic compounds containing 8 carbon atoms is carried out in two steps: an isomerisation step and a dehydrogenation step. In FIG. 1, the feed to be treated is introduced into isomerisation zone R1 via line 1. Substantially pure hydrogen is introduced into line 1 via line 12 and recycled hydrogen is introduced into line 1 via line 13. Hydrogen which circulates in line 13 is purged via line 15. The effluent from isomerisation zone R1 is sent to a separation zone S1 via line 2. In S1, hydrogen contained in the effluent is isolated and recycled to the inlet to isomerisation zone R1 via line 13, the remaining effluent being evacuated from this separation zone S1 via line 3. The fluid contained in line 3 is heated in an oven F1 then evacuated therefrom via line 4. The effluent leaving the oven is enriched in recycled hydrogen via line 14 then it is introduced into dehydrogenation zone R2. The effluent from zone R2 is sent via line 5 to separation zone S2.

Abstract: For isomerising aromatic compounds containing eight carbon atoms in the presence of hydrogen, a mixture containing compounds with a boiling point of about 80° C. to 135° C. comprising at least one paraffin containing eight carbon atoms, at least one naphthene containing eight carbon atoms, at least benzene and at least toluene is added to the feed before introducing it into the isomerisation reactor R via line 1. These additions are made by a recycle via line 6 or by adding fresh compounds via line 11, or be a combination of fresh and recycled compounds via lines 6 and 11. Hydrogen is added via line 15.