Patents by Inventor Marc Roger Fernand Orval

Marc Roger Fernand Orval has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fermentation of fastidious bacterial strain in perfusion suspension culture
    Patent number: 9701936
    Abstract: The present invention relates to improved processes for culturing bacteria, in particular to processes for perfusion suspension culturing of bacteria in a fermenter, wherein the culture medium including the bacteria is circulated over a separation system in alternating tangential flow, wherein the separation system removes a filtrate containing inhibitory metabolites from the culture medium.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: July 11, 2017
    Assignee: GLAXOSMITHKLINE BIOLOGICALS S.A.
    Inventors: Philippe Marc Helene Dehottay, Michael Lanero Fidalgo, Dominique Janssens, Marc Roger Fernand Orval
  • FERMENTATION PROCESS
    Publication number: 20150166948
    Abstract: The present invention relates to improved processes for culturing bacteria, in particular to processes for perfusion suspension culturing of bacteria in a fermenter, wherein the culture medium including the bacteria is circulated over a separation system in alternating tangential flow, wherein the separation system removes a filtrate containing inhibitory metabolites from the culture medium.
    Type: Application
    Filed: June 24, 2013
    Publication date: June 18, 2015
    Inventors: Philippe Marc Helene Dehottay, Michael Lanero Fidalgo, Dominique Janssens, Marc Roger Fernand Orval
  • Fermentation Process for the Production of Diphtheria Toxin
    Publication number: 20140242635
    Abstract: The present invention relates to a fermentation process comprising a fermentation step of growing a strain of Corynebacterium diphtheriae in medium in a fermenter under conditions of agitation sufficient to maintain a homogenous culture and limited aeration such that pO2 within the culture falls to less than 4% for the majority of the fermentation step.
    Type: Application
    Filed: March 14, 2014
    Publication date: August 28, 2014
    Applicant: GLAXOSMITHKLINE BIOLOGICALS S.A.
    Inventors: Philippe Marc Helene DEHOTTAY, Sandrine DESSOY, Olivier Marc Serge Ghislain LALOUX, Marc Roger Fernand ORVAL
  • Fermentation Process for the Production of Diphtheria Toxin
    Publication number: 20080193475
    Abstract: The present invention relates to a fermentation process comprising a fermentation step of growing a strain of Corynebacterium diphtheria in medium in a fermenter under conditions of agitation sufficient to maintain a homogenous culture and limited aeration such that pO2 within the culture falls to less than 4% for the majority of the fermentation step.
    Type: Application
    Filed: March 21, 2006
    Publication date: August 14, 2008
    Inventors: Philippe Marc Helene Dehottay, Sandrine Dessoy, Olivier Marc Serge Ghislain Laloux, Marc Roger Fernand Orval