Patents by Inventor Marc SAPOVAL

Marc SAPOVAL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240050390
    Abstract: The present invention relates to an embolizing emulsion comprising iodinated oil and an aqueous phase comprising a water-soluble contrast agent for use in the treatment of inflammatory hypervascularization associated with a musculoskeletal disorder.
    Type: Application
    Filed: December 10, 2021
    Publication date: February 15, 2024
    Applicants: ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS, GUERBET, UNIVERSITÉ PARIS CITÉ
    Inventors: Marc SAPOVAL, Constantino DEL GIUDICE, Carole DEAN, Olivier PELLERIN
  • Publication number: 20220409668
    Abstract: The present invention relates to a genetically modified human stem cell, in which said human stem cell comprises an exogenous nucleic acid comprising a region coding for a fusion protein comprising a mutant human cytochrome P450 2B6 (CYP2B6*) protein of SEQ ID No. 1 or a variant or fragment thereof and an NADPH-cytochrome P450 reductase protein of SEQ ID No. 2 or a variant or fragment thereof, functionally bound to a promoter, said exogenous nucleic acid having been integrated into one of the genomic safe harbors of said human stem cell. The invention also relates to the use of said cell for the treatment of cancer and/or cancer recurrences and/or associated metastases, particularly the solid tumours, and in particular the hepatocellular carcinomas and/or associated metastases.
    Type: Application
    Filed: October 13, 2020
    Publication date: December 29, 2022
    Inventors: Isabelle DE WAZIERS, Philippe BEAUNE, Marc SAPOVAL, Olivier PELLERIN, Benjamin NAYAGOM