Patents by Inventor Marc Spingola

Marc Spingola has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isothermal strand displacement nucleic acid amplification
    Patent number: 6214587
    Abstract: Methods for amplifying target nucleic acid sequences using a nucleic acid polymerase lacking 5′ exonuclease activity and a set of oligonucleotide primers. Preferably, a primer array is used. The primer array contains two sets of primers. One set contains at least two complementary primers. The other set contains at least two sense primers. Using the described methods amplification can be carried out under essentially constant environmental conditions without the requirement for exonuclease activity or restriction endonuclease activity.
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: April 10, 2001
    Assignee: Gen-Probe Incorporated
    Inventors: Nanibhushan Dattagupta, Paul Douglas Stull, Marc Spingola, Daniel Louis Kacian
  • Isothermal strand displacement nucleic acid amplification
    Patent number: 6087133
    Abstract: Methods for amplifying target nucleic acid sequences using a nucleic acid polymerase lacking 5' exonuclease activity and a set of oligonucleotide primers. Preferably, a primer array is used. The primer array contains two sets of primers. One set contains at least two complementary primers. The other set contains at least two sense primers. Using the described methods amplification can be carried out under essentially constant environmental conditions without the requirement for exonuclease activity or restriction endonuclease activity.
    Type: Grant
    Filed: November 18, 1997
    Date of Patent: July 11, 2000
    Assignee: Gen-Probe Incorporated
    Inventors: Nanibhushan Dattagupta, Paul Douglas Stull, Marc Spingola, Daniel Louis Kacian
  • Compositions for the detection of Chlamydia trachomatis
    Patent number: 5514551
    Abstract: Oligonucleotides and methods for the amplification and specific detection of Chlamydia trachomatis. The invention relates to amplification oligonucleotides capable of amplifying Chlamydia trachomatis nucleotide sequences and to probes and helper oligonucleotides for the specific detection of Chlamydia trachomatis nucleic acids. The invention also relates to methods for using the oligonucleotides of the present invention and specific combinations and kits useful for the detection of Chlamydia trachomatis.
    Type: Grant
    Filed: October 14, 1994
    Date of Patent: May 7, 1996
    Assignee: Gen-Probe Incorporated
    Inventors: Yeasing Yang, Paul D. Stull, Marc Spingola
  • Methods for the detection of Chlamydia trachomatis
    Patent number: 5512445
    Abstract: Oligonucleotides and methods for the amplification and specific detection of Chlamydia trachomatis. The invention relates to amplification oligonucleotides capable of amplifying Chlamydia trachomatis nucleotide sequences and to probes and helper oligonucleotides for the specific detection of Chlamydia trachomatis nucleic acids. The invention also relates to methods for using the oligonucleotides of the present invention and specific combinations and kits useful for the detection of Chlamydia trachomatis.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: April 30, 1996
    Assignee: Gen-Probe Incorporated
    Inventors: Yeasing Yang, Paul D. Stull, Marc Spingola
  • Isothermal strand displacement nucleic acid amplification
    Patent number: RE38960
    Abstract: Methods for amplifying target nucleic acid sequences using a nucleic acid polymerase lacking 5? exonuclease activity and a set of oligonucleotide primers. Preferably, a primer array is used. The primer array contains two sets of primers. One set contains at least two complementary primers. The other set contains at least two sense primers. Using the described methods amplification can be carried out under essentially constant environmental conditions without the requirement for exonuclease activity or restriction endonuclease activity.
    Type: Grant
    Filed: June 7, 2002
    Date of Patent: January 31, 2006
    Assignee: Gen-Probe Incorporated
    Inventors: Nanibhushan Dattagupta, Paul Douglas Stull, Marc Spingola, Daniel Louis Kacian
  • Isothermal strand displacement nucleic acid amplification
    Patent number: RE39007
    Abstract: Methods for amplifying target nucleic acid sequences using a nucleic acid polymerase lacking 5? exonuclease activity and a set of oligonucleotide primers. Preferably, a primer array is used. The primer array contains two sets of primers. One set contains at least two complementary primers. The other set contains at least two sense primers. Using the described methods amplification can be carried out under essentially constant environmental conditions without the requirement for exonuclease activity or restriction endonu- clease activity.
    Type: Grant
    Filed: June 7, 2002
    Date of Patent: March 7, 2006
    Assignee: Gen-Probe Incorporated
    Inventors: Nanibhushan Dattagupta, Paul Douglas Stull, Marc Spingola, Daniel Louis Kacian