Patents by Inventor Marc Therrien

Marc Therrien has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biosensor for detecting RAF/KSR family kinase dimerization and uses thereof
    Patent number: 9464313
    Abstract: Disclosed herein are biosensors useful for detecting the dimerization of RAF and/or KSR polypeptides. These biosensors comprise fusion proteins comprising RAF and/or KSR proteins fused to bioluminescent or fluorescent proteins. Also disclosed are methods of using the biosensors to detect and measure the dimerization of RAF/RAF and RAF/KSR polypeptides by resonance energy transfer such as BRET or FRET, for example to screen for inhibitors of dimerization.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: October 11, 2016
    Assignees: MOUNT SINAI HOSPITAL, UNIVERSITÉ DE MONTRÉAL
    Inventors: Hugo Lavoie, Malha Sahmi, Marc Therrien, Thanashan Rajakulendran, Frank Sicheri
  • RAF DIMERS AND USES THEREOF
    Publication number: 20140378324
    Abstract: Disclosed herein are mutated RAF and KSR nucleic acids and polypeptides. Also disclosed are methods of using the mutated RAF and KSR to inhibit the dimerization of RAF/RAF and RAF/KSR. Also disclosed are methods of using the mutated RAF and KSR to screen for inhibitors of dimerization.
    Type: Application
    Filed: December 20, 2013
    Publication date: December 25, 2014
    Applicants: MOUNT SINAI HOSPITAL, UNIVERSITE DE MONTREAL
    Inventors: HUGO LAVOIE, Malha Sahmi, Marc Therrien, Thanashan Rajakulendran, Frank Sicheri
  • RAF DIMERS AND USES THEREOF
    Publication number: 20120190039
    Abstract: Disclosed herein are mutated RAF and KSR nucleic acids and polypeptides. Also disclosed are methods of using the mutated RAF and KSR to inhibit the dimerization of RAF/RAF and RAF/KSR. Also disclosed are methods of using the mutated RAF and KSR to screen for inhibitors of dimerization.
    Type: Application
    Filed: January 23, 2012
    Publication date: July 26, 2012
    Inventors: Hugo Lavoie, Malha Sahmi, Marc Therrien, Thanashan Rajakulendran, Frank Sicheri
  • NOVEL PROTEIN MEMBER OF THE RAS/MAPK PATHWAY, ANTIBODIES THEREOF AND METHODS AND KITS OF USING SAME
    Publication number: 20090042233
    Abstract: A polypeptide comprising a SAM domain, the sequence of said SAM domain being as set forth in SEQ ID NO: 33.
    Type: Application
    Filed: April 2, 2007
    Publication date: February 12, 2009
    Inventors: Marc THERRIEN, Malha Sahmi, Melanie Douziech
  • Protein kinase required for RAS signal transduction
    Patent number: 5747275
    Abstract: The kinase suppressor of Ras (Ksr), a novel protein kinase involved in the regulation of cell growth and differentiation, provides an important target for therapeutic intervention. The subject compositions also include nucleic acids which encode a Ksr kinase, and hybridization probes and primers capable of hybridizing with a Ksr gene. Such probes are used to identify mutant Ksr alleles associated with disease. The invention includes methods, including phosphorylation and binding assays, for screening chemical libraries for lead compounds for a pharmacological agent useful in the diagnosis or treatment of disease associated Ksr activity or Ksr-dependent signal transduction.
    Type: Grant
    Filed: August 12, 1997
    Date of Patent: May 5, 1998
    Assignee: The Regents of the University of California
    Inventors: Gerry Rubin, Marc Therrien, Henry Chang, Felix Karim, David Wassarman
  • Protein kinase required for Ras signal transduction
    Patent number: 5747288
    Abstract: The kinase suppressor of Ras (Ksr), a novel protein kinase involved in the regulation of cell growth and differentiation, provides an important target for therapeutic intervention. The subject compositions also include nucleic acids which encode a Ksr kinase, and hybridization probes and primers capable of hybridizing with a Ksr gene. Such probes are used to identify mutant Ksr alleles associated with disease. The invention includes methods, including phosphorylation and binding assays, for screening chemical libraries for lead compounds for a pharmacological agent useful in the diagnosis or treatment of disease associated Ksr activity or Ksr-dependent signal transduction.
    Type: Grant
    Filed: June 12, 1997
    Date of Patent: May 5, 1998
    Assignee: The Regents of the University of California
    Inventors: Gerry Rubin, Marc Therrien, Henry Chang, Felix Karim, David Wassarman
  • Protein kinase required for Ras signal transduction
    Patent number: 5700675
    Abstract: The kinase suppressor of Ras (Ksr), a novel protein kinase involved in the regulation of cell growth and differentiation, provides an important target for therapeutic intervention. The subject compositions also include nucleic acids which encode a Ksr kinase, and hybridization probes and primers capable of hybridizing with a Ksr gene. Such probes are used to identify mutant Ksr alleles associated with disease. The invention includes methods, including phosphorylation and binding assays, for screening chemical libraries for lead compounds for a pharmacological agent useful in the diagnosis or treatment of disease associated Ksr activity or Ksr-dependent signal transduction.
    Type: Grant
    Filed: December 13, 1995
    Date of Patent: December 23, 1997
    Assignee: Regents of the University of California
    Inventors: Gerry Rubin, Marc Therrien, Henry Chang, Felix Karim, David Wassarman