Patents by Inventor Marc V. Gorenstein
Marc V. Gorenstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8480110Abstract: Methods and apparatus for LC/IMS/MS analysis involve obtaining noisy raw data from a sample, convolving the data with an artifact-reducing filter, and locating, in retention-time, ion mobility, and mass-to-charge-ratio dimensions, one or more ion peaks of the convolved data.Type: GrantFiled: April 13, 2012Date of Patent: July 9, 2013Assignee: Waters Technologies CorporationInventors: Marc V. Gorenstein, Guo-Zhong Li
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Patent number: 8447527Abstract: A method for matching a precursor ion with one or more related product ions includes providing input data sets obtained from sample injections, each of the data sets including a precursor ion and one or more product ions, normalizing the input data sets in accordance with a single retention time for the precursor ion, determining which product ions are within a predetermined retention time window with respect to the single retention time, and, if a product ion is within the predetermined retention time window for a specified number of the input data sets, determining that the product ion is related to the precursor having the single retention time. An apparatus for analyzing a sample includes a chromatography module, a mass-spectrometry module in communication with the chromatography module, and control unit in communication with the chromatography module and the mass-spectrometry module.Type: GrantFiled: March 14, 2012Date of Patent: May 21, 2013Assignee: Waters Technologies CorporationInventors: Marc V. Gorenstein, Scott J. Geromanos, Jeffrey Cruz Silva, Guo-Zhong Li
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Patent number: 8440465Abstract: A method for analyzing chemicals includes fractionating a complex sample into at least two sample portions that each include portions of two polypeptides though in different concentration ratios, digesting and performing LC/MS on each of the sample portions, and associating precursor ions observed via LC/MS with their corresponding polypeptide in response to LC/MS-provided intensity data. A set of precursor-ions that has substantially similar intensity ratios in both sample portions is determined to be associated with the same polypeptide.Type: GrantFiled: February 24, 2012Date of Patent: May 14, 2013Assignee: Waters Technologies CorporationInventors: Marc V. Gorenstein, Scott J. Geromanos, Jeffrey Cruz Silva, Guo-Zhong Li
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Publication number: 20130116933Abstract: Embodiments of the present invention are directed to apparatus and methods for performing mass spectrometry. Data pair information is subjected to an ion audit process in which data pair information that relates to scored compounds is subtracted from the data pair information. The depleted information more readily reveals data pair information for compounds present with smaller signals.Type: ApplicationFiled: November 7, 2011Publication date: May 9, 2013Inventors: Scott J. GEROMANOS, Guo-Zhong Li, Jeffrey C. Silva, Marc V. Gorenstein, Hans Vissers
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Publication number: 20120259557Abstract: Methods and apparatus for LC/IMS/MS analysis involve obtaining noisy raw data from a sample, convolving the data with an artifact-reducing filter, and locating, in retention-time, ion mobility, and mass-to-charge-ratio dimensions, one or more ion peaks of the convolved data.Type: ApplicationFiled: April 13, 2012Publication date: October 11, 2012Inventors: Marc V. Gorenstein, Guo-Zhong Li
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Publication number: 20120253684Abstract: A method for matching a precursor ion with one or more related product ions includes providing input data sets obtained from sample injections, each of the data sets including a precursor ion and one or more product ions, normalizing the input data sets in accordance with a single retention time for the precursor ion, determining which product ions are within a predetermined retention time window with respect to the single retention time, and, if a product ion is within the predetermined retention time window for a specified number of the input data sets, determining that the product ion is related to the precursor having the single retention time. An apparatus for analyzing a sample includes a chromatography module, a mass-spectrometry module in communication with the chromatography module, and control unit in communication with the chromatography module and the mass-spectrometry module.Type: ApplicationFiled: March 14, 2012Publication date: October 4, 2012Applicant: Waters Technologies CorporationInventors: Marc V. GORENSTEIN, Scott Geromanos, Jeffrey Cruz Silva, Guo-Zhong Li
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Publication number: 20120225444Abstract: A method for analyzing chemicals includes fractionating a complex sample into at least two sample portions that each include portions of two polypeptides though in different concentration ratios, digesting and performing LC/MS on each of the sample portions, and associating precursor ions observed via LC/MS with their corresponding polypeptide in response to LC/MS-provided intensity data. A set of precursor-ions that has substantially similar intensity ratios in both sample portions is determined to be associated with the same polypeptide.Type: ApplicationFiled: February 24, 2012Publication date: September 6, 2012Applicant: Waters Technologies CorporationInventors: Marc V. GORENSTEIN, Scott J. Geromanos, Jeffrey Cruz Silva, Guo-Zhong Li
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Patent number: 8178834Abstract: Methods and apparatus for LC/IMS/MS analysis involve obtaining noisy raw data from a sample, convolving the data with an artifact-reducing filter, and locating, in retention-time, ion mobility, and mass-to-charge-ratio dimensions, one or more ion peaks of the convolved data.Type: GrantFiled: May 25, 2007Date of Patent: May 15, 2012Assignee: Waters Technologies CorporationInventors: Marc V. Gorenstein, Guo-Zhong Li
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Patent number: 8165820Abstract: A method for matching a precursor ion with one or more related product ions includes providing input data sets obtained from sample injections, each of the data sets including a precursor ion and one or more product ions, normalizing the input data sets in accordance with a single retention time for the precursor ion, determining which product ions are within a predetermined retention time window with respect to the single retention time, and, if a product ion is within the predetermined retention time window for a specified number of the input data sets, determining that the product ion is related to the precursor having the single retention time. An apparatus for analyzing a sample includes a chromatography module, a mass-spectrometry module in communication with the chromatography module, and a control unit in communication with the chromatography module and the mass-spectrometry module.Type: GrantFiled: June 5, 2006Date of Patent: April 24, 2012Assignee: Waters Technologies CorporationInventors: Marc V. Gorenstein, Scott J. Geromanos, Jeffrey Cruz Silva, Guo-Zhong Li
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Patent number: 8143066Abstract: A method (100) for analyzing chemicals includes fractionating a complex sample into at least two sample portions that each includes portions of two polypeptides though in different concentration ratios, digesting and performing LC/MS on each of the sample portions (110, and associating precursor ions observed via LC/MS with their corresponding polypeptide in response to LC/MS provided intensity data (170). A set of precursor ions that has substantially similar intensity ratios in both sample portions is determined to be associated with the same polypeptide.Type: GrantFiled: June 5, 2006Date of Patent: March 27, 2012Assignee: Waters Technologies CorporationInventors: Marc V. Gorenstein, Scott J. Geromanos, Jeffrey Cruz Silva, Guo-Zhong Li
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Patent number: 8106350Abstract: A method of mass spectrometry is disclosed wherein distortions in a mass spectrum are corrected for by determining or estimating the number of ions Qi which arrived in an ith time bin, wherein: Formula (I) and wherein qi is the actual total number of ion arrival events recorded in the ith time bin and x is an integer corresponding to the number of time bins which correspond with an estimated deadtime period.Type: GrantFiled: February 22, 2006Date of Patent: January 31, 2012Assignee: Micromass UK LimitedInventors: Martin Green, Jason Lee Wildgoose, Marc V. Gorenstein
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Patent number: 8105838Abstract: A method (100) for performing chemical analyses includes digesting a reference sample to obtain precursors associated with a peptide in the sample (110), separating the precursors to determine values associated with retention times of the separated precursors (120), ionizing the separated precursors to form precursor ions (130), mass analyzing the precursor ions to determine values associated with mass and with ion intensity (140), and storing a <fcfile of the polypeptide defined by the determined values (150). A subject sample is analyzed (160), and the polypeptide is detected in the subject sample in response to a match between subject-sample and profile values. An apparatus (900) for performing chemical analyses includes a chromatography module (904), a mass-spectrometry module (912), and a computer module (926).Type: GrantFiled: June 5, 2006Date of Patent: January 31, 2012Assignee: Waters Technologies CorporationInventors: Marc V. Gorenstein, Scott Geromanos, Jeffrey Cruz Silva, Guo-Zhong Li
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Patent number: 8076635Abstract: Embodiments of the present invention are directed to apparatus and methods for performing mass spectrometry. Data pair information is subjected to an ion audit process in which data pair information that relates to scored compounds is subtracted from the data pair information. The depleted information more readily reveals data pair information for compounds present with smaller signals.Type: GrantFiled: May 24, 2007Date of Patent: December 13, 2011Assignee: Waters Technologies CorporationInventors: Scott J. Geromanos, Guo-Zhong Li, Jeffrey C. Silva, Marc V. Gorenstein, Hans Vissers
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Publication number: 20110226941Abstract: Techniques are described for matching a precursor ion with one or more related product ions, including providing a plurality of input data sets obtained from a plurality of injections, each of the plurality of input data sets including a same precursor ion and one or more product ions, normalizing the plurality of input data sets in accordance with a single retention time for the precursor ion, for each of the plurality of input data sets, determining which product ions are within a predetermined retention time window with respect to the single retention time for the precursor ion, and if a product ion is within the predetermined retention time window in at least one of the plurality of input data sets, determining that the product ion is related to the precursor ion having the single retention timeType: ApplicationFiled: May 29, 2009Publication date: September 22, 2011Applicant: WATERS TECHNOLOGIES CORPORATIONInventors: Marc V. Gorenstein, Martha Degen Stapels, Scott Geromanos, Jeffrey C. Silva, Guo-Zhong Li
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Patent number: 8017908Abstract: Chromatograms and mass spectra produced by an LC/MS system are analyzed by creating a two-dimensional data matrix of the spectral and chromatographic data. The two-dimensional matrix can be created by placing the spectra generated by the mass spectrometer portion of the LC/MS system in successive columns of the data matrix. In this way, the rows of the data matrix correspond to chromatographic data and the columns of the data matrix correspond to the spectra. A two-dimensional filter is specified and applied to the data matrix to enhance the ability of the system to detect peaks associated with ions. The two-dimensional filter is specified according to desired criteria. Rank-1 and rank-2 filters can be specified to improve computational efficiency. One method of applying the two-dimensional filter is through convolution of the data matrix with the two-dimensional filter to produce an output data matrix. Peaks corresponding to detected ions are identified in the output data matrix.Type: GrantFiled: December 18, 2009Date of Patent: September 13, 2011Assignee: Waters Technologies CorporationInventors: Marc V. Gorenstein, Robert S. Plumb, Chris L. Stumpf
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Publication number: 20110184648Abstract: A method for matching a precursor ion with one or more related product ions includes providing input data sets obtained from sample injections, each of the data sets including a precursor ion and one or more product ions, normalizing the input data sets in accordance with a single retention time for the precursor ion, determining which product ions are within a predetermined retention time window with respect to the single retention time, and, if a product ion is within the predetermined retention time window for a specified number of the input data sets, determining that the product ion is related to the precursor having the single retention time. An apparatus for analyzing a sample includes a chromatography module, a mass-spectrometry module in communication with the chromatography module, and a control unit in communication with the chromatography module and the mass-spectrometry module.Type: ApplicationFiled: June 5, 2006Publication date: July 28, 2011Applicant: WATERS INVESTMENTS LIMITEDInventors: Marc V. Gorenstein, Scott J. Geromanos, Jeffrey Cruz Silva, Guo-Zhong Li
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Publication number: 20100280811Abstract: An apparatus and a method of chemical analysis entail acquiring a chromatogram, median filtering the chromatogram to produce a model baseline, smoothing the model baseline to reduce noise, and subtracting the smoothed model baseline from the acquired chromatogram to produce a modified chromatogram having a substantially flat baseline.Type: ApplicationFiled: October 25, 2006Publication date: November 4, 2010Applicant: WATERS INVESTMENTS LIMITEDInventors: Marc V. Gorenstein, Anthony C. Gilby
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Publication number: 20100187414Abstract: Chromatograms and mass spectra produced by an LC/MS system are analyzed by creating a two-dimensional data matrix of the spectral and chromatographic data. The two-dimensional matrix can be created by placing the spectra generated by the mass spectrometer portion of the LC/MS system in successive columns of the data matrix. In this way, the rows of the data matrix correspond to chromatographic data and the columns of the data matrix correspond to the spectra. A two-dimensional filter is specified and applied to the data matrix to enhance the ability of the system to detect peaks associated with ions. The two-dimensional filter is specified according to desired criteria. Rank-1 and rank-2 filters can be specified to improve computational efficiency. One method of applying the two-dimensional filter is through convolution of the data matrix with the two-dimensional filter to produce an output data matrix. Peaks corresponding to detected ions are identified in the output data matrix.Type: ApplicationFiled: December 18, 2009Publication date: July 29, 2010Applicant: WATERS TECHNOLOGIES CORPORATIONInventors: Marc V. Gorenstein, Robert S. Plumb, Chris L. Stumpf
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Patent number: 7645984Abstract: Chromatograms and mass spectra produced by an LC/MS system are analyzed by creating a two-dimensional data matrix of the spectral and chromatographic data. The two-dimensional matrix can be created by placing the spectra generated by the mass spectrometer portion of the LC/MS system in successive columns of the data matrix. In this way, the rows of the data matrix correspond to chromatographic data and the columns of the data matrix correspond to the spectra. A two-dimensional filter is specified and applied to the data matrix to enhance the ability of the system to detect peaks associated with ions. The two-dimensional filter is specified according to desired criteria. Rank-1 and rank-2 filters can be specified to improve computational efficiency. One method of applying the two-dimensional filter is through convolution of the data matrix with the two-dimensional filter to produce an output data matrix. Peaks corresponding to detected ions are identified in the output data matrix.Type: GrantFiled: February 11, 2005Date of Patent: January 12, 2010Assignee: Waters Technologies CorporationInventors: Marc V. Gorenstein, Robert S. Plumb, Chris L. Stumpf
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Publication number: 20090317791Abstract: A method (100) for analyzing chemicals includes fractionating a complex sample into at least two sample portions that each includes potions of two polypeptides though in different concentration ratios, digesting and performing LC/MS on each of the sample portions (110, and associating precursor ions observed via LC/MS with their corresponding polypeptide in response to LC/MS provided intensity data (170). A set of precursor ions that has substantially similar intensity ratios in both sample portions is determined to be associated with the same polypeptide.Type: ApplicationFiled: June 5, 2006Publication date: December 24, 2009Applicant: WATERS INVESTMENTS LIMITEDInventors: Marc V. Gorenstein, Scott J. Geromanos, Jeffrey Cruz Silva, Guo-Zhong Li