Abstract: The invention relates to small photosensitizers, their process of preparation and uses of the compounds in optical imaging and photodynamic therapy. The invention provides a compound of formula (I), a derivative or a salt thereof Wherein R1 is selected from the group consisting of amines, anilines, phenols, thiophenols, selenols and aryl groups; R2 and R3 independently are H or halogen; R4 is selected from the group consisting of H, nitro and cyano: and R5 and R6 independently are either absent or oxygen or methyl.

Abstract: The invention relates to small photosensitizers, their process of preparation and uses of the compounds in optical imaging and photodynamic therapy. The invention provides a compound of formula (I), a derivative or a salt thereof Wherein R1 is selected from the group consisting of amines, anilines, phenols, thiophenols, selenols and aryl groups; R2 and R3 independently are H or halogen; R4 is selected from the group consisting of H, nitre and cyano: and R5 and R6 independently are either absent or oxygen or methyl.

Abstract: The invention relates to small, conjugatable, orthogonal and tunable fluorophores for imaging of small bioactive molecules. The invention further relates to processes for the preparation of the compounds, and uses of the compounds in therapeutic, diagnostic, surgery and analytical applications. The invention provides a compound of formula (I), a derivative or a salt thereof. Wherein X is selected from the group consisting of NH, O, S, SeR5R6, CR7R8; R1 is selected from the group consisting of amines, alcohols, thiols, thiophenols, selenols, selenophenols and aryl groups; R2 and R3 are independently H or a halogen; R4 tis either H, nitro or cyano; R5 is either absent or methyl or oxygen; R6 is either absent or methyl or oxygen; and R7 and R8 are independently selected from the group consisting of linear or cyclic alkyl groups containing halogen, amino, cyano or carboxylic ester substituents, and alkyl aryl groups.

Abstract: A probe is provided comprising a label and a binding moiety, wherein the binding moiety is adapted to bind to gram-negative bacteria, and to substantially not bind to animal cells or gram-positive bacteria. A method of detecting the presence of bacteria in a target area is also provided, which allows the detection of bacteria generally, and the determination of whether that bacteria is gram negative or gram positive.

Abstract: A probe for detecting bacteria and/or fungi in vitro and in vivo is provided, the probe having a core and a plurality of probe elements; each probe element within the plurality of probe elements extending from the core and having a fluorophore and a binding moiety, wherein the binding moiety is a bacteria binding moiety and selectively binds to bacteria and/or to fungi and not to animal cells. Methods of use of the probe and kits comprising the probe are also provided.

Abstract: A probe is provided comprising a label and a binding moiety, Deliver First Probe wherein the binding moiety is adapted to bind to gram-negative bacteria, and to Target Area to substantially not bind to animal cells or gram-positive bacteria. A method of detecting the presence of bacteria in a target area is also provided, which allows the detection of bacteria generally, and the determination of whether that bacteria is gram negative or gram positive.

Abstract: A probe is provided comprising a core and a plurality of probe elements; each probe element within the plurality of probe elements extending from the core and comprising a fluorophore and a binding moiety. Methods of use of the probe and kits comprising the probe are also provided.

Abstract: A library of novel amino-triazolyl-BODIPY compounds is described. Particular compounds of the library serve as selective fluorescent probes for human serum albumin (HSA) and for live primary neurons. The fluorescent probe for HSA binds uniquely and specifically to the fatty acid site 1 of HSA, and thus proves a valuable and unique probe for drugs that bind to such a site on HSA. Methods of synthesis for the library compounds are also described.

Abstract: The present invention discloses a series of alkylamino BODIPY dyes, methods for preparing a library of alkyl-amino BODIPY dyes via solid-phase synthesis, and the use of the alkyl-amino BODIPY dyes as fluorescent sensors for protein detection, cell imaging and cytometry applications, and staining of certain cell line.

Abstract: A compound of structural formula (I): The values and alternative values are as defined herein. The invention also includes biosensors comprising nanoparticles functionalized with a compound of structural formula (I). Also described is a method for labeling a biomolecule using a compound of structural formula (I) and a method of detecting a target biomolecule using a compound of structural formula (I) or a biosensor of the invention.

Abstract: A library of novel amino-triazolyl-BODIPY compounds is described. Particular compounds of the library serve as selective fluorescent probes Human Serum Albumin (HSA) and for live primary neurons. The fluorescent probe for HSA binds uniquely and specifically to the fatty acid site 1 of HSA, and thus proves a valuable and unique probe for drugs that bind to such a site on HSA. Methods of synthesis for the library compounds are also described.

Abstract: The present invention discloses a series of alkylamino BODIPY dyes, methods for preparing a library of alkyl-amino BODIPY dyes via solid-phase synthesis, and the use of the alkyl-amino BODIPY dyes as fluorescent sensors for protein detection, cell imaging and cytometry applications, and staining of certain cell line.

Abstract: Pyrrolopyrimidine derivatives of Formula (I) that are useful as JAK3 kinase inhibitors.

Abstract: Pyrrolopyrimidine derivatives of Formula (I) that are useful as JAK3 kinase inhibitors.