Patents by Inventor Marc W. Kirschner
Marc W. Kirschner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
DIAGNOSTIC METHOD BASED ON LARGE SCALE IDENTIFICATION OF POST-TRANSLATIONAL MODIFICATION OF PROTEINS
Publication number: 20150309044Abstract: Methods for the large scale identification of post-translational modification states of proteins and enzyme activities for carrying out post-translational modification reactions involve the analysis of functional extracts from fresh and frozen samples using protein arrays. The methods and kits of the present invention can be used to analyze and characterize compounds for their effects on post-translational modifications and their pathways. The methods and kits can also be used to diagnose and characterize a wide variety of diseases and medical conditions, including cancer, neurodegenerative diseases, immune diseases, infectious diseases, genetic diseases, metabolic conditions, and drug effects using cells or body fluids of a patient.Type: ApplicationFiled: July 10, 2015Publication date: October 29, 2015Inventors: Yifat Merbl, Marc W. Kirschner -
Publication number: 20150298091Abstract: The present invention generally relates to microfluidics and labeled nucleic acids. For example, certain aspects are generally directed to systems and methods for labeling nucleic acids within microfluidic droplets. In one set of embodiments, the nucleic acids may include “barcodes” or unique sequences that can be used to distinguish nucleic acids in a droplet from those in another droplet, for instance, even after the nucleic acids are pooled together. In some cases, the unique sequences may be incorporated into individual droplets using particles and attached to nucleic acids contained within the droplets (for example, released from lysed cells). In some cases, the barcodes may be used to distinguish tens, hundreds, or even thousands of nucleic acids, e.g., arising from different cells or other sources.Type: ApplicationFiled: June 9, 2015Publication date: October 22, 2015Inventors: David A. Weitz, Allon Moshe Klein, Ilke Akartuna, Linas Mazutis, Marc W. Kirschner
-
Publication number: 20150293058Abstract: Embodiments are directed to a method, a computer readable medium encoded with instructions that, when executed, perform a method, and a system for performing mass spectrometry analysis. Molecules of different samples may be labeled with a chemical tag, allowing a multiplexed analysis of multiple samples. The labeled molecules may be fragmented, each fragmented molecule creating at least two separate ions. The relative abundance of each of the heavier ions, which may comprise the original molecule from the sample, may be measured. A relative abundance of the labeled molecules in each of the samples may be determined from the measured relative abundances of the heavier ions.Type: ApplicationFiled: October 22, 2013Publication date: October 15, 2015Applicant: President and Fellows of Harvard CollegeInventors: Martin Helmut Wuhr, Steven P. Gygi, Wilhelm Haas, Graeme Conrad McAlister, Leonid Peshkin, Ramin Rad, Marc W. Kirschner
-
Publication number: 20100297747Abstract: Microsystem for monitoring cell growth. A microfluidic structure is designed to allow cells to circulate therethrough and the microfluidic structure includes modules to monitor mass, mass density and fluorescence of the cell.Type: ApplicationFiled: October 24, 2008Publication date: November 25, 2010Inventors: Scott R. Manalis, Andrea K. Bryan, Yao-Chung Weng, Thomas Burg, William H. Grover, Marc W. Kirschner, Paul Jorgensen, Michel Godin
-
DIAGNOSTIC METHOD BASED ON LARGE SCALE IDENTIFICATION OF POST-TRANSLATIONAL MODIFICATION OF PROTEINS
Publication number: 20100160177Abstract: Methods for the large scale identification of post-translational modification states of proteins and enzyme activities for carrying out post-translational modification reactions involve the analysis of functional extracts from fresh and frozen samples using protein arrays. The methods and kits of the present invention can be used to analyze and characterize compounds for their effects on post-translational modifications and their pathways. The methods and kits can also be used to diagnose and characterize a wide variety of diseases and medical conditions, including cancer, neurodegenerative diseases, immune diseases, infectious diseases, genetic diseases, metabolic conditions, and drug effects using cells or body fluids of a patient.Type: ApplicationFiled: January 29, 2010Publication date: June 24, 2010Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Yifat Merbl, Marc W. Kirschner -
Patent number: 6844193Abstract: Disclosed herein are compositions and methods which are useful in the identification and isolation of components involved in transmembrane receptor-mediated signaling. Such components include the receptors themselves (e.g., tyrosine kinase receptors, cytokine receptors and tyrosine phosphatase receptors), as well as ligands which bind the receptors and modulators of the downstream intracellular catalytic event which characterizes receptor-mediated signalling. Two novel ligands for the FGF receptor and the nucleotide sequences encoding them are also described.Type: GrantFiled: December 10, 2001Date of Patent: January 18, 2005Assignee: President and Fellows of Harvard CollegeInventors: Marc W. Kirschner, Noriyuki Kinoshita
-
Publication number: 20030170866Abstract: Disclosed are novel human and clam ubiquitin carrier polypeptides involved in the ubiquitination of cyclins A and/or B. Also disclosed are inhibitors of such polypeptides, nucleic acids encoding such polypeptides and inhibitors, antibodies specific for such polypeptides, and methods of their use.Type: ApplicationFiled: February 10, 2003Publication date: September 11, 2003Applicant: Harvard UniversityInventors: Joan V. Ruderman, Avram Hershko, Marc W. Kirschner, Fiona Townsley, Alexander Aristarkhov, Esther Eytan, Hongtao Yu
-
Publication number: 20030148462Abstract: The invention provides nucleic acid molecules, designated separase nucleic acid molecules, which encode separase, an endopeptidase that modulates sister chromatid separation. The invention also provides recombinant expression vectors containing separase nucleic acid molecules and host cells into which the expression vectors have been introduced. The invention still further provides separase proteins, fusion proteins, antigenic peptides and anti-separase antibodies. The invention also provides methods for the identification of modulators of separase, methods of modulating separase, methods of modulating sister chromatid separation, and methods for the treatment of disorders related to aberrant sister chromatid separation, such as cancer, Down's syndrome, and spontaneous fetal abortion.Type: ApplicationFiled: December 16, 2002Publication date: August 7, 2003Applicant: President and fellows of Harvard CollegeInventors: Marc W. Kirschner, Olaf Stemmann, Hui Zou, Steven P. Gygi
-
Patent number: 6548290Abstract: The claimed invention pertains to a novel protein called Geminin which is able to inhibit DNA replication and/or induce neurogenesis. The claimed invention includes the amino acid sequence, the nucleic acid sequence, and various domains thereof. The invention further relates to methods for treating patients with a proliferative disease by administering an effective amount of the Geminin protein and/or nucleic acid. Similarly, the claimed inventions pertains to methods for treating various neurological disorders by administering neuronal cells which were differentiated by exposure to Geminin.Type: GrantFiled: June 11, 1998Date of Patent: April 15, 2003Assignee: President and Fellows of Harvard CollegeInventors: Thomas J. McGarry, Kristen Kroll, Marc W. Kirschner
-
Patent number: 6528633Abstract: Disclosed are novel human and clam ubiquitin carrier polypeptides involved in the ubiquitination of cyclins A and/or B. Also disclosed are inhibitors of such polypeptides, nucleic acids encoding such polypeptides and inhibitors, antibodies specific for such polypeptides, and methods of their use.Type: GrantFiled: January 29, 2001Date of Patent: March 4, 2003Assignees: President and Fellows of Havard College, Rappaport Family Institute for Research in the Medical SciencesInventors: Joan V. Ruderman, Avram Hershko, Marc W. Kirschner, Fiona Townsley, Alexander Aristarkov, Esther Eytan, Hongtao Yu
-
Publication number: 20020090651Abstract: Disclosed herein are compositions and methods which are useful in the identification and isolation of components involved in transmembrane receptor-mediated signaling. Such components include the receptors themselves (e.g., tyrosine kinase receptors, cytokine receptors and tyrosine phosphatase receptors), as well as ligands which bind the receptors and modulators of the downstream intracellular catalytic event which characterizes receptor-mediated signalling. Two novel ligands for the FGF receptor and the nucleotide sequences encoding them are also described.Type: ApplicationFiled: December 10, 2001Publication date: July 11, 2002Applicant: President and Fellows of Harvard CollegeInventors: Marc W. Kirschner, Noriyuki Kinoshita
-
Publication number: 20020086401Abstract: Disclosed are novel human and clam ubiquitin carrier polypeptides involved in the ubiquitination of cyclins A and/or B. Also disclosed are inhibitors of such polypeptides, nucleic acids encoding such polypeptides and inhibitors, antibodies specific for such polypeptides, and methods of their use.Type: ApplicationFiled: January 29, 2001Publication date: July 4, 2002Inventors: Joan V. Ruderman, Avram Hershko, Marc W. Kirschner, Fiona Townsley, Alexander Aristarkov, Esther Eytan, Hongtao Yu
-
Patent number: 6399386Abstract: Disclosed herein are compositions and methods which are useful in the identification and isolation of components involved in transmembrane receptor-mediated signaling. Such components include the receptors themselves (e.g., tyrosine kinase receptors, cytokine receptors and tyrosine phosphatase receptors), as well as ligands which bind the receptors and modulators of the downstream intracellular catalytic event which characterizes receptor-mediated signalling. Two novel ligands for the FGF receptor and the nucleotide sequences encoding them are also described.Type: GrantFiled: February 18, 2000Date of Patent: June 4, 2002Assignee: President and Fellows of Harvard CollegeInventors: Marc W. Kirschner, Noriyuki Kinoshita
-
Patent number: 6180379Abstract: Disclosed are novel human and clam ubiquitin carrier polypeptides involved in the ubiquitination of cyclins A and/or B. Also disclosed are inhibitors of such polypeptides, nucleic acids encoding such polypeptides and inhibitors, antibodies specific for such polypeptides, and methods of their use.Type: GrantFiled: March 31, 1997Date of Patent: January 30, 2001Assignee: President and Fellows of Harvard UniversityInventors: Joan V. Ruderman, Avram Hershko, Marc W. Kirschner, Fiona Townsley, Alexander Aristarkov, Esther Eytan, Hongtao Yu
-
Patent number: 6127158Abstract: Disclosed herein are novel ubiquitin-conjugating enzymes and methods for using same. More specifically, disclosed are nucleic acid sequences encoding the UBC9 protease.Type: GrantFiled: December 7, 1994Date of Patent: October 3, 2000Assignee: President and Fellows of Harvard CollegeInventors: Stefan Jentsch, Marc W. Kirschner, Randall W. King, P. Renee Yew
-
Patent number: 6080718Abstract: Disclosed herein are compositions and methods which are useful in the identification and isolation of components involved in transmembrane receptor-mediated signaling. Such components include the receptors themselves (e.g., tyrosine kinase receptors, cytokine receptors and tyrosine phosphatase receptors), as well as ligands which bind the receptors and modulators of the downstream intracellular catalytic event which characterizes receptor-mediated signalling. Two novel ligands for the FGF receptor and the nucleotide sequences encoding them are also described.Type: GrantFiled: June 23, 1997Date of Patent: June 27, 2000Assignee: President and Fellows of Harvard CollegeInventors: Marc W. Kirschner, Noriyuki Kinoshita
-
Patent number: 6066460Abstract: The invention provides a method for isolating nucleic acids encoding proteins comprising a signal peptide, e.g., a secreted protein. The method of the invention comprises isolating an RNA molecule associated with an endoplasmic reticulumn membrane preparation under conditions wherein the RNA is at least partially translated. The invention also provides a library of nucleic acids encoding proteins comprising a signal peptide, individual nucleic acids isolated according to the method of the invention, peptides encoded thereby, pharmaceutical compositions comprising such and kits for performing the method of the invention.Type: GrantFiled: July 24, 1998Date of Patent: May 23, 2000Assignee: President and Fellows of Harvard CollegeInventors: Marc W. Kirschner, Noriyuki Kinoshita
-
Patent number: 5955288Abstract: Disclosed herein are compositions and methods which are useful in the identification and isolation of components involved in transmembrane receptor-mediated signaling. Such components include the receptors themselves (e.g., tyrosine kinase receptors, cytokine receptors and tyrosine phosphatase receptors), as well as ligands which bind the receptors and modulators of the downstream intracellular catalytic event which characterizes receptor-mediated signalling.Type: GrantFiled: October 18, 1996Date of Patent: September 21, 1999Assignee: President and Fellows of Harvard CollegeInventors: Marc W. Kirschner, Noriyuki Kinoshita
-
Patent number: 5866098Abstract: The present invention concerns a novel paracrine signaling assay.Type: GrantFiled: December 13, 1996Date of Patent: February 2, 1999Assignee: President and Fellows of Harvard CollegeInventors: Kevin D. Lustig, Marc W. Kirschner
-
Patent number: 5766923Abstract: Disclosed herein are compositions and methods which are useful in the identification and isolation of components involved in transmembrane receptor-mediated signaling. Such components include the receptors themselves (e.g., tyrosine kinase receptors, cytokine receptors and tyrosine phosphatase receptors), as well as ligands which bind the receptors and modulators of the downstream intracellular catalytic event which characterizes receptor-mediated signalling. Two novel ligands for the FGF receptor and the nucleotide sequences encoding them are also described.Type: GrantFiled: May 15, 1995Date of Patent: June 16, 1998Assignee: President & Fellows of Harvard CollegeInventors: Marc W. Kirschner, Noriyuki Kinoshita