Abstract: Provided herein are compositions of matter, e.g. solid forms, pharmaceutical compositions, pharmaceutical combinations and unit dosage forms, of a compound of the following structural formula: (I) or a pharmaceutically acceptable salt thereof, or a hydrate of either of the foregoing. The compositions of matter described herein can be used to treat tyrosine kinase non-receptor 1 (TNK1)-mediated diseases, disorders and/or conditions.

Abstract: A method for performing sub-nanometer three-dimensional magnetic resonance imaging of a sample under ambient conditions using a diamond having at least one shallowly planted nitrogen-vacancy (NV) center. A driving radio-frequency (RF) signal and a microwave signal are applied to provide independent control of the NV spin and the target dark spins. A magnetic-field gradient is applied to the sample with a scanning magnetic tip to provide a narrow spatial volume in which the target dark electronic spins are on resonance with the driving RF field. The sample is controllably scanned by moving the magnetic tip to systematically bring non-resonant target dark spins into resonance with RF signal. The dark spins are measured and mapped by detecting magnetic resonance of said nitrogen-vacancy center at each of said different magnetic tip positions. The dark-spin point-spread-function for imaging the dark spins is directly measured by the NV center.

Abstract: A method for performing sub-nanometer three-dimensional magnetic resonance imaging of a sample under ambient conditions using a diamond having at least one shallowly planted nitrogen-vacancy (NV) center. A driving radio-frequency (RF) signal and a microwave signal are applied to provide independent control of the NV spin and the target dark spins. A magnetic-field gradient is applied to the sample with a scanning magnetic tip to provide a narrow spatial volume in which the target dark electronic spins are on resonance with the driving RF field. The sample is controllably scanned by moving the magnetic tip to systematically bring non-resonant target dark spins into resonance with RF signal. The dark spins are measured and mapped by detecting magnetic resonance of said nitrogen-vacancy center at each of said different magnetic tip positions. The dark-spin point-spread-function for imaging the dark spins is directly measured by the NV center.

Abstract: A process for providing a simulated date and/or time to a time-sensitive application is disclosed herein. Such a process may include detecting the invocation of a time handler method configured to retrieve system time. Upon detecting the invocation, the contents of a call stack may be captured and analyzed to determine which requestor method initiated the invocation. The process may then determine whether the requestor method should receive a real or simulated system time. A real system time may be returned to the requestor method in the event it should receive the real system time. A simulated system time may be returned to the requestor method in the event it should receive the simulated system time. A corresponding apparatus and computer program product are also disclosed and claimed herein.

Abstract: A process for providing a simulated date and/or time to a time-sensitive application is disclosed herein. Such a process may include detecting the invocation of a time handler method configured to retrieve system time. Upon detecting the invocation, the contents of a call stack may be captured and analyzed to determine which requester method initiated the invocation. The process may then determine whether the requester method should receive a real or simulated system time. A real system time may be returned to the requester method in the event it should receive the real system time. A simulated system time may be returned to the requester method in the event it should receive the simulated system time. A corresponding apparatus and computer program product are also disclosed and claimed herein.

Abstract: A process for providing a simulated date and/or time to a time-sensitive application is disclosed herein. Such a process may include detecting the invocation of a time handler method configured to retrieve system time. Upon detecting the invocation, the contents of a call stack may be captured and analyzed to determine which requestor method initiated the invocation. The process may then determine whether the requestor method should receive a real or simulated system time. A real system time may be returned to the requestor method in the event it should receive the real system time. A simulated system time may be returned to the requestor method in the event it should receive the simulated system time. A corresponding apparatus and computer program product are also disclosed and claimed herein.

Abstract: A process for providing a simulated date and/or time to a time-sensitive application is disclosed herein. Such a process may include detecting the invocation of a time handler method configured to retrieve system time. Upon detecting the invocation, the contents of a call stack may be captured and analyzed to determine which requester method initiated the invocation. The process may then determine whether the requester method should receive a real or simulated system time. A real system time may be returned to the requester method in the event it should receive the real system time. A simulated system time may be returned to the requester method in the event it should receive the simulated system time. A corresponding apparatus and computer program product are also disclosed and claimed herein.