Abstract: A patient interface includes a plenum chamber pressurisable to a therapeutic pressure, and a seal-forming structure constructed and arranged to seal with a region of a patient's face surrounding an entrance to a patient's airways. The seal-forming structure is constructed and arranged to maintain the therapeutic pressure in the plenum chamber throughout a patient's respiratory cycle in use. The patient interface also includes a positioning and stabilizing structure configured to hold the seal-forming structure in a therapeutically effective position on a patients head. The positioning and stabilizing structure includes a rear strap arranged to contact an occiput of the patient's head. The rear strap is constructed from a first material is arranged to contact a temporal region of the patient's head, and a second material arranged to contact the occiput of the patients head. The second material is silicone.

Abstract: It relates to a pharmaceutical combination comprising a KRAS G12C inhibitor, in particular 1-{6-[(4M)-4-(5-Chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro [3.3] heptan-2-yl} prop-2-en-1-one (Compound A) and one or more therapeutically active agents selected from a SHP2 inhibitor (e.g. TNO155) and a PD-1 inhibitor, pharmaceutical compositions comprising the same; and methods of using such combinations and compositions in the treatment or prevention of a cancer or a tumor, in particular wherein the cancer or tumor is KRAS G12C mutated.

Abstract: Aspects of the present technology comprise a positioning and stabilising structure to hold a seal-forming structure in a therapeutically effective position on a head of a patient. The seal-forming structure may be constructed and arranged to form a seal with a region of the patient's face surrounding an entrance to the patient's airways for sealed delivery of a flow of air at a therapeutic pressure of at least 4 cmH2O with respect to ambient air pressure throughout the patient's respiratory cycle in use. The positioning and stabilising structure may comprise at least one gas delivery tube to deliver the flow of air to the entrance of a patient's airways via the seal-forming structure. The positioning and stabilising structure may comprise an adjustment mechanism for adjustment of a length of the at least one gas delivery tube to enable the positioning and stabilising structure to fit different size heads.

Abstract: Aspects of the present technology comprise a positioning and stabilising structure to hold a seal-forming structure in a therapeutically effective position on a head of a patient. The seal-forming structure may be constructed and arranged to form a seal with a region of the patient's face surrounding an entrance to the patient's airways for sealed delivery of a flow of air at a therapeutic pressure of at least 4 cmH2O with respect to ambient air pressure throughout the patient's respiratory cycle in use. The positioning and stabilising structure may comprise at least one gas delivery tube to deliver the flow of air to the entrance of a patient's airways via the seal-forming structure. The positioning and stabilising structure may comprise an adjustment mechanism for adjustment of a length of the at least one gas delivery tube to enable the positioning and stabilising structure to fit different size heads.

Abstract: A patient interface includes a plenum chamber pressurisable to a therapeutic pressure, and a seal-forming structure constructed and arranged to seal with a region of a patient's face surrounding an entrance to a patients airways. The seal-forming structure is constructed and arranged to maintain the therapeutic pressure in the plenum chamber throughout a patients respiratory cycle in use. The patient interface also includes a positioning and stabilizing structure configured to hold the seal-forming structure in a therapeutically effective position on a patients head. The positioning and stabilizing structure includes a rear strap arranged to contact an occiput of the patients head. The rear strap is constructed from a first material is arranged to contact a temporal region of the patients head, and a second material arranged to contact the occiput of the patients head. The second material is silicone.

Abstract: Aspects of the present technology comprise a positioning and stabilising structure to hold a seal-forming structure in a therapeutically effective position on a head of a patient. The seal-forming structure may be constructed and arranged to form a seal with a region of the patient's face surrounding an entrance to the patient's airways for sealed delivery of a flow of air at a therapeutic pressure of at least 4 cmH2O with respect to ambient air pressure throughout the patient's respiratory cycle in use. The positioning and stabilising structure may comprise at least one gas delivery tube to deliver the flow of air to the entrance of a patient's airways via the seal-forming structure. The positioning and stabilising structure may comprise an adjustment mechanism for adjustment of a length of the at least one gas delivery tube to enable the positioning and stabilising structure to fit different size heads.

Abstract: Aspects of the present technology comprise a positioning and stabilising structure to hold a seal-forming structure in a therapeutically effective position on a head of a patient. The positioning and stabilising structure may comprise at least one gas delivery tube to deliver the flow of air to the entrance of a patient's airways via the seal-forming structure. The at least one gas delivery tube may be constructed and arranged to contact, in use, at least a region of the patient's head superior to an otobasion superior of the patient's head. The positioning and stabilising structure may comprise an adjustment mechanism for adjustment of a length of the at least one gas delivery tube to enable the positioning and stabilising structure to fit different size heads.

Abstract: A method for spraying a fluid onto a charge air cooler of a motor vehicle includes measuring a first temperature with the aid of a first sensor of the motor vehicle; measuring a second temperature with the aid of a second sensor of the motor vehicle; comparing the first temperature with a first reference temperature by a controller of the motor vehicle; comparing the second temperature with a second reference temperature by the controller of the motor vehicle if the first temperature is higher than the first reference temperature or equal to the first reference temperature; and spraying at least some of the fluid onto the charge air cooler during a spray-on cycle if the second temperature is higher than the second reference temperature or equal to the second reference temperature.

Abstract: Aspects of the present technology comprise a positioning and stabilising structure to hold a seal-forming structure in a therapeutically effective position on a head of a patient. The positioning and stabilising structure may comprise at least one gas delivery tube to deliver the flow of air to the entrance of a patient's airways via the seal-forming structure. The at least one gas delivery tube may be constructed and arranged to contact, in use, at least a region of the patient's head superior to an otobasion superior of the patient's head. The positioning and stabilising structure may comprise an adjustment mechanism for adjustment of a length of the at least one gas delivery tube to enable the positioning and stabilising structure to fit different size heads.

Abstract: A method for spraying a fluid onto a charge air cooler of a motor vehicle includes measuring a first temperature with the aid of a first sensor of the motor vehicle; measuring a second temperature with the aid of a second sensor of the motor vehicle; comparing the first temperature with a first reference temperature by a controller of the motor vehicle; comparing the second temperature with a second reference temperature by the controller of the motor vehicle if the first temperature is higher than the first reference temperature or equal to the first reference temperature; and spraying at least some of the fluid onto the charge air cooler during a spray-on cycle if the second temperature is higher than the second reference temperature or equal to the second reference temperature.

Abstract: A method adapts a drive torque that is transmitted to driven wheels of a motor vehicle, especially during cornering. A supplementary torque which arises during a gear change operation and is produced by a moment of inertia, in particular that of an engine, is transmitted to the driven wheels in dependence on a longitudinal/transverse acceleration of the motor vehicle and of a friction coefficient of the tires.

Abstract: A telephone has several lists of phone numbers. Each phone number within a list has a number of digits which is not less than a predetermined minimum number, and not more than a predetermined maximum number. The maximum number is the “size” of the list. When a digit is entered, the phone compares (1B) the number of digits entered to the lists, and selects (1C) the list of the smallest size which is greater than or equal to the number of digits entered. That list is searched (1D) and the results displayed (1E) when the search is complete. If another digit is entered during the search (1F), the comparing (1B) and list selecting (1C) steps are repeated.

Abstract: A system and method for reducing power consumed by an integrated electronic device. The device includes a personal data assistant (PDA) unit and a wireless telephone integrated in a common housing. A common display on the housing is used for displaying messages from both the PDA and the wireless telephone to a user. A controller, coupled to the wireless telephone, places the wireless telephone in a power-off state after expiration of a predetermined period of time following cessation of voice traffic activity on the wireless telephone. The controller switches the wireless telephone from the power-off state to a power-on state if, during operation in the power-off state, a user begins an attempt to place an outgoing call with the wireless telephone. The wireless telephone is unable to receive an incoming call when the wireless telephone is in the power-off state.

Abstract: A device and method provide for an accurate output from a unit, such as an oscillator and/or clock providing an output indicative of frequency and/or time. The device includes a processing section having a microprocessor that develops a model characterizing the performance of the device, including establishing predicted accuracy variations, and the model is then used to correct the unit output. An external reference is used to provide a reference input for updating the model, including updating of predicted variations of the unit, by comparison of the reference input with the unit output. The ability of the model to accurately predict the performance of the unit improves as additional updates are carried out, and this allows the interval between the updates to be lengthened and/or the overall accuracy of the device to be improved. The accuracy of the output is thus adaptively optimized in the presence of systematic and random variations.