Abstract: The invention pertains to methods and means for the targeted modulation of B-cell mediated immune responses by bringing into contact a B-cell with a specific ratio of soluble single monovalent antigens and complexed multivalent antigens. The targeted modulation of B-cell immunity can be used in mammals for the diagnosis and therapy of various conditions associated with antibody-mediated immunity. Such conditions include proliferative disorders such as cancer, autoimmune disorders, pathogenic infections, inflammatory diseases, allergies and food intolerances. The invention is predicated on the observation that complexed multivalent antigenic structures induce a strong IgG type antibody B-cell response while surprisingly monovalent antigenic structures harbour the ability to suppress such IgG responses, or even induce in the case of autoantigens protective IgM responses. The invention in this regard offers methods, compositions, therapeutics, diagnostics and food additives.

Abstract: The invention pertains to methods and means for the targeted modulation of B-cell mediated immune responses by bringing into contact a B-cell with a specific ratio of soluble single monovalent antigens and complexed multivalent antigens. The targeted modulation of B-cell immunity can be used in mammals for the diagnosis and therapy of various conditions associated with antibody-mediated immunity. Such conditions include proliferative disorders such as cancer, autoimmune disorders, pathogenic infections, inflammatory diseases, allergies and food intolerances. The invention is predicated on the observation that complexed multivalent antigenic structures induce a strong IgG type antibody B-cell response while surprisingly monovalent antigenic structures harbour the ability to suppress such IgG responses, or even induce in the case of autoantigens protective IgM responses, in particular protective oligomeric anti-insulin antibodies.

Abstract: Suggested edits to translated text are enabled to be provided by users. The suggested edits are associated with the translated text in a content database. A subsequent user may view the translated text and any associated suggested edits. The subsequent user may be enabled to approve a suggested edit to the translated text. The translated text is enabled to be displayed as modified according to the approved suggested edit. This may include enabling multiple instances of the translated text to be displayed as modified according to the suggested edit if the translated text occurs multiple times (e.g., appears multiple times in one or more documents) in the content database. Further users that attempt to view the translated text in a document of the content database will be provided with the modified version of the translated text.

Abstract: Suggested edits to translated text are enabled to be provided by users. The suggested edits are associated with the translated text in a content database. A subsequent user may view the translated text and any associated suggested edits. The subsequent user may be enabled to approve a suggested edit to the translated text. The translated text is enabled to be displayed as modified according to the approved suggested edit. This may include enabling multiple instances of the translated text to be displayed as modified according to the suggested edit if the translated text occurs multiple times (e.g., appears multiple times in one or more documents) in the content database. Further users that attempt to view the translated text in a document of the content database will be provided with the modified version of the translated text.