Patents by Inventor Marc Zabeau
Marc Zabeau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120214706Abstract: The present invention relates to the rapid detection of clusters of single nucleotide polymorphisms (SNPs) using an array technology. It further relates to the use of these clusters as markers in strain improvement and breeding, and in strain identification.Type: ApplicationFiled: October 5, 2010Publication date: August 23, 2012Inventor: Marc Zabeau
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Patent number: 7996157Abstract: The present invention is in the field of nucleic acid-based genetic analysis. More particularly, it discloses novel insights into the overall structure of genetic variation in all living species. The structure can be revealed with the use of any data set of genetic variants from a particular locus. The invention is useful to define the subset of variations that are most suited as genetic markers to search for correlations with certain phenotypic traits. Additionally, the insights are useful for the development of algorithms and computer programs that convert genotype data into the constituent haplotypes that are laborious and costly to derive in an experimental way. The invention is useful in areas such as (i) genome-wide association studies, (ii) clinical in vitro diagnosis, (iii) plant and animal breeding, (iv) the identification of micro-organisms.Type: GrantFiled: September 3, 2009Date of Patent: August 9, 2011Assignee: Methexis Genomics N.V.Inventors: Marc Zabeau, Patrick Stanssens, Yannick Gansemans
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Patent number: 7974789Abstract: The present invention is in the field of nucleic acid-based genetic analysis. More particularly, it discloses novel insights into the overall structure of genetic variation in all living species. The structure can be revealed with the use of any data set of genetic variants from a particular locus. The invention is useful to define the subset of variations that are most suited as genetic markers to search for correlations with certain phenotypic traits. Additionally, the insights are useful for the development of algorithms and computer programs that convert genotype data into the constituent haplotypes that are laborious and costly to derive in an experimental way. The invention is useful in areas such as (i) genome-wide association studies, (ii) clinical in vitro diagnosis, (iii) plant and animal breeding, (iv) the identification of micro-organisms.Type: GrantFiled: July 29, 2009Date of Patent: July 5, 2011Assignee: Methexis Genomics N.V.Inventors: Marc Zabeau, Patrick Stanssens, Yannick Gansemans
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Publication number: 20110104677Abstract: The invention relates to a process for the controlled amplification of at least one part of a starting DNA containing a plurality of restriction sites for a determined specific restriction endonuclease, and of which at least part of its nucleic acid is unknown. This technology can be applied to human, animal or plant DNA fingerprinting, to identify restriction fragment length polymorphisms. Also encompassed by the inventive technology are kits for the application of the process.Type: ApplicationFiled: July 18, 2010Publication date: May 5, 2011Inventors: MARC ZABEAU, PIETER VOS
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Patent number: 7935488Abstract: The invention relates to a process for the controlled amplification of at least one part of a starting DNA containing a plurality of restriction sites for a determined specific restriction endonuclease, and of which at least part of its nucleic acid is unknown. This technology can be applied to human, animal or plant DNA fingerprinting, to identify restriction fragment length polymorphisms. Also encompassed by the inventive technology are kits for the application of the process.Type: GrantFiled: October 5, 2010Date of Patent: May 3, 2011Assignee: Keygene N.V.Inventors: Marc Zabeau, Pieter Vos
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Publication number: 20110059457Abstract: The invention relates to a process for the controlled amplification of at least one part of a starting DNA containing a plurality of restriction sites for a determined specific restriction endonuclease, and of which at least part of its nucleic acid is unknown. This technology can be applied to human, animal or plant DNA fingerprinting, to identify restriction fragment length polymorphisms. Also encompassed by the inventive technology are kits for the application of the process.Type: ApplicationFiled: October 5, 2010Publication date: March 10, 2011Inventors: MARC ZABEAU, PIETER VOS
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Publication number: 20100323353Abstract: The present invention is directed at a novel method to enhance the genetic improvement of industrial microorganisms. More specifically, the present invention is directed at molecular methods for the identification of genetic variants that contribute to the genetic improvement of the microorganisms. The methods of the present invention comprise novel approaches for identifying genetic markers that linked to said genetic variants, and for using said genetic markers to select improved industrial microorganisms. In one of the embodiments, the genetic markers linked to said genetic variants are identified in microbial populations that are subjected to directed evolution. In another embodiment the genetic markers linked to said genetic variants are identified in microbial sub populations that have been prescreened for improved characteristics.Type: ApplicationFiled: November 27, 2008Publication date: December 23, 2010Inventor: Marc Zabeau
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Publication number: 20100267023Abstract: The invention relates to a process for the controlled amplification of at least one part of a starting DNA containing a plurality of restriction sites for a determined specific restriction endonuclease, and of which at least part of its nucleic acid is unknown. Application of this process to human, animal or plant DNA fingerprinting, to identification of restriction fragment length polymorphisms. Kit for the application of the process.Type: ApplicationFiled: June 15, 2009Publication date: October 21, 2010Inventors: Marc Zabeau, Pieter Vos
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Publication number: 20100092964Abstract: The present invention is in the field of nucleic acid-based genetic analysis. More particularly, it discloses novel insights into the overall structure of genetic variation in all living species. The structure can be revealed with the use of any data set of genetic variants from a particular locus. The invention is useful to define the subset of variations that are most suited as genetic markers to search for correlations with certain phenotypic traits. Additionally, the insights are useful for the development of algorithms and computer programs that convert genotype data into the constituent haplotypes that are laborious and costly to derive in an experimental way. The invention is useful in areas such as (i) genome-wide association studies, (ii) clinical in vitro diagnosis, (iii) plant and animal breeding, (iv) the identification of micro-organisms.Type: ApplicationFiled: July 29, 2009Publication date: April 15, 2010Applicant: METHEXIS GENOMICS N.V.Inventors: Marc Zabeau, Patrick Stanssens, Yannick Gansemans
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Publication number: 20100082261Abstract: The present invention is in the field of nucleic acid-based genetic analysis. More particularly, it discloses novel insights into the overall structure of genetic variation in all living species. The structure can be revealed with the use of any data set of genetic variants from a particular locus. The invention is useful to define the subset of variations that are most suited as genetic markers to search for correlations with certain phenotypic traits. Additionally, the insights are useful for the development of algorithms and computer programs that convert genotype data into the constituent haplotypes that are laborious and costly to derive in an experimental way. The invention is useful in areas such as (i) genome-wide association studies, (ii) clinical in vitro diagnosis, (iii) plant and animal breeding, (iv) the identification of micro-organisms.Type: ApplicationFiled: September 3, 2009Publication date: April 1, 2010Applicant: METHEXIS GENOMICS N.V.Inventors: Marc Zabeau, Patrick Stanssens, Yannick Gansemans
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Patent number: 7593818Abstract: The present invention is in the field of nucleic acid-based genetic analysis. More particularly, it discloses novel insights into the overall structure of genetic variation in all living species. The structure can be revealed with the use of any data set of genetic variants from a particular locus. The invention is useful to define the subset of variations that are most suited as genetic markers to search for correlations with certain phenotypic traits. Additionally, the insights are useful for the development of algorithms and computer programs that convert genotype data into the constituent haplotypes that are laborious and costly to derive in an experimental way. The invention is useful in areas such as (i) genome-wide association studies, (ii) clinical in vitro diagnosis, (iii) plant and animal breeding, (iv) the identification of micro-organisms.Type: GrantFiled: March 9, 2005Date of Patent: September 22, 2009Assignee: Methexis Genomics N.V.Inventors: Marc Zabeau, Patrick Stanssens, Yannick Gansemans
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Patent number: 7584058Abstract: The present invention is in the field of nucleic acid-based genetic analysis. More particularly, it discloses novel insights into the overall structure of genetic variation in all living species. The structure can be revealed with the use of any data set of genetic variants from a particular locus. The invention is useful to define the subset of variations that are most suited as genetic markers to search for correlations with certain phenotypic traits. Additionally, the insights are useful for the development of algorithms and computer programs that convert genotype data into the constituent haplotypes that are laborious and costly to derive in an experimental way. The invention is useful in areas such as (i) genome-wide association studies, (ii) clinical in vitro diagnosis, (iii) plant and animal breeding, (iv) the identification of micro-organisms.Type: GrantFiled: February 26, 2004Date of Patent: September 1, 2009Assignee: Methexis Genomics N.V.Inventors: Marc Zabeau, Patrick Stanssens, Yannick Gansemans
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Patent number: 7572583Abstract: The invention relates to a process for the controlled amplification of at least one part of a starting DNA containing a plurality of restriction sites for a determined specific restriction endonuclease, and of which at least part of its nucleic acid is unknown. Application of this process to human, animal or plant DNA fingerprinting, to identification of restriction fragment length polymorphisms. Kit for the application of the process.Type: GrantFiled: August 17, 2005Date of Patent: August 11, 2009Assignee: Keygene N.V.Inventors: Marc Zabeau, Pieter Vos
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Publication number: 20090104601Abstract: The present invention is in the field of nucleic acid-based genetic analysis. More particularly, it discloses novel insights into the overall structure of genetic variation in all living species. The structure can be revealed with the use of any data set of genetic variants from a particular locus. The invention is useful to define the subset of variations that are most suited as genetic markers to search for correlations with certain phenotypic traits. Additionally, the insights are useful for the development of algorithms and computer programs that convert genotype data into the constituent haplotypes that are laborious and costly to derive in an experimental way. The invention is useful in areas such as (i) genome-wide association studies, (ii) clinical in vitro diagnosis, (iii) plant and animal breeding, (iv) the identification of micro-organisms.Type: ApplicationFiled: March 9, 2006Publication date: April 23, 2009Applicant: Methexis Genomics N.V.Inventors: Marc Zabeau, Patrick Stanssens, Yannick Gansemans
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Publication number: 20060257888Abstract: The present invention is in the field of nucleic acid-based genetic analysis. More particularly, it discloses novel insights into the overall structure of genetic variation in all living species. The structure can be revealed with the use of any data set of genetic variants from a particular locus. The invention is useful to define the subset of variations that are most suited as genetic markers to search for correlations with certain phenotypic traits. Additionally, the insights are useful for the development of algorithms and computer programs that convert genotype data into the constituent haplotypes that are laborious and costly to derive in an experimental way. The invention is useful in areas such as (i) genome-wide association studies, (ii) clinical in vitro diagnosis, (iii) plant and animal breeding, (iv) the identification of micro-organisms.Type: ApplicationFiled: December 19, 2005Publication date: November 16, 2006Applicant: METHEXIS GENOMICS, N.V.Inventors: Marc Zabeau, Patrick Stanssens, Yannick Gansemans
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Publication number: 20060252061Abstract: The present invention is in the field of nucleic acid-based diagnostic assays. More particularly, it relates to methods useful for the “diagnostic sequencing” of regions of sample nucleic acids for which a prototypic or reference sequence is already available (also referred to as “re-sequencing”), or which may be determined using the methods described herein. This diagnostic technology is useful in areas that require such re-sequencing in a rapid and reliable way: (i) the identification of the various allelic sequences of a certain region/gene, (ii) the scoring of disease-associated mutations. (iii) the detection of somatic variations, (iv) studies in the field of molecular evolution, (v) the determination of the nucleic acid sequences of prokaryotic and eukaryotic genomes; (vi) identifying one or more nucleic acids in one or more biological samples; (vii) and determining the expression profile of genes in a biological sample and other areas.Type: ApplicationFiled: February 6, 2006Publication date: November 9, 2006Applicant: Sequenom, Inc.Inventors: Marc Zabeau, Patrick Stanssens
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Patent number: 7026115Abstract: The invention relates to a process for the controlled amplification of at least one part of a starting DNA containing a plurality of restriction sites for a determined specific restriction endonuclease, and of which at least part or its nucleic acid is unknown. Application of this process to human, animal or plant DNA fingerprinting, to identification of restriction fragment length polymorphisms. Kit for the application of the process.Type: GrantFiled: December 19, 1996Date of Patent: April 11, 2006Assignee: Keygene N.V.Inventors: Marc Zabeau, Pieter Vos
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Publication number: 20060035261Abstract: The invention relates to a process for the controlled amplification of at least one part of a starting DNA containing a plurality of restriction sites for a determined specific restriction endonuclease, and of which at least part of its nucleic acid is unknown. Application of this process to human, animal or plant DNA fingerprinting, to identification of restriction fragment length polymorphisms. Kit for the application of the process.Type: ApplicationFiled: August 17, 2005Publication date: February 16, 2006Applicant: Keygene N.V.Inventors: Marc Zabeau, Pieter Vos
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Patent number: 6994969Abstract: The present invention is in the field of nucleic acid-based diagnostic assays. More particularly, it relates to methods useful for the “diagnostic sequencing” of regions of sample nucleic acids for which a prototypic or reference sequence is already available (also referred to as “re-sequencing”), or which may be determined using the methods described herein. This diagnostic technology is useful in areas that require such re-sequencing in a rapid and reliable way: (i) the identification of the various allelic sequences of a certain region/gene, (ii) the scoring of disease-associated mutations, (iii) the detection of somatic variations, (iv) studies in the field of molecular evolution, (v) the determination of the nucleic acid sequences of prokaryotic and eukaryotic genomes, (vi) identifying one or more nucleic acids in one or more biological samples', (vii) and determining the expression profile of genes in a biological sample and other areas.Type: GrantFiled: April 30, 2000Date of Patent: February 7, 2006Assignee: Methexis Genomics, N.V.Inventors: Marc Zabeau, Patrick Stanssens
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Publication number: 20050277135Abstract: The present invention is in the field of nucleic acid-based genetic analysis. More particularly, it discloses novel insights into the overall structure of genetic variation in all living species. The structure can be revealed with the use of any data set of genetic variants from a particular locus. The invention is useful to define the subset of variations that are most suited as genetic markers to search for correlations with certain phenotypic traits. Additionally, the insights are useful for the development of algorithms and computer programs that convert genotype data into the constituent haplotypes that are laborious and costly to derive in an experimental way. The invention is useful in areas such as (i) genome-wide association studies, (ii) clinical in vitro diagnosis, (iii) plant and animal breeding, (iv) the identification of micro-organisms.Type: ApplicationFiled: March 9, 2005Publication date: December 15, 2005Applicant: METHEXIS GENOMICS NVInventors: Marc Zabeau, Patrick Stanssens, Yannick Gansemans