Patents by Inventor Marcel Andre BREUNING

Marcel Andre BREUNING has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell culture media
    Patent number: 10619131
    Abstract: The present invention relates to cell culture media comprising inorganic ester derivatives of tyrosine and/or cysteine. The poor solubility of tyrosine and the often non-sufficient stability of cysteine in cell culture media is overcome by substituting them with an inorganic ester derivative, e.g. with a phosphorylated derivative.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: April 14, 2020
    Assignee: Merck Patent GmbH
    Inventors: Joerg Von Hagen, Marcel Andre Breuning, Christian Jasper
  • CELL CULTURE MEDIA
    Publication number: 20180230422
    Abstract: The present invention relates to cell culture media comprising inorganic ester derivatives of tyrosine and/or cysteine. The poor solubility of tyrosine and the often non-sufficient stability of cysteine in cell culture media is overcome by substituting them with an inorganic ester derivative, e.g. with a phosphorylated derivative.
    Type: Application
    Filed: April 13, 2018
    Publication date: August 16, 2018
    Applicant: Merck Patent GmbH
    Inventors: Joerg VON HAGEN, Marcel Andre BREUNING, Christian JASPER
  • Cell culture media
    Patent number: 10030225
    Abstract: The present invention relates to cell culture media comprising inorganic ester derivatives of tyrosine and/or cysteine. The poor solubility of tyrosine and the often non-sufficient stability of cysteine in cell culture media is overcome by substituting them with an inorganic ester derivative, e.g. with a phosphorylated derivative.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: July 24, 2018
    Assignee: Merck Patent GmbH
    Inventors: Joerg Von Hagen, Marcel Andre Breuning, Christian Jasper
  • SYNTHESIS OF 1-ALKYL-2-AMINO-IMIDAZOL-5-CARBOXYLIC ACID ESTER VIA CALPHA-SUBSTITUTED N-ALKYL-GLYCINE ESTER DERIVATIVES
    Publication number: 20160251387
    Abstract: The invention provides an efficient and high yielding process for preparing TH-302, comprising at least one step wherein a dioxolane intermediate is generated in an aqueous layer, resulting in a synthesis that is amenable to scale up conditions.
    Type: Application
    Filed: October 10, 2014
    Publication date: September 1, 2016
    Inventors: Christian JASPER, Helmut Dieter HAHN, Marcel Andre BREUNING, Philipp KRATTIGER, Michaela DEBOR
  • CELL CULTURE MEDIA
    Publication number: 20150337258
    Abstract: The present invention relates to cell culture media comprising inorganic ester derivatives of tyrosine and/or cysteine. The poor solubility of tyrosine and the often non-sufficient stability of cysteine in cell culture media is overcome by substituting them with an inorganic ester derivative, e.g. with a phosphorylated derivative.
    Type: Application
    Filed: November 14, 2013
    Publication date: November 26, 2015
    Applicant: Merck Patent GmbH
    Inventors: Joerg VON HAGEN, Marcel Andre BREUNING, Christian JASPER