Patents by Inventor Marcel De Jong
Marcel De Jong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10327449Abstract: A variant polypeptide having alpha-amylase activity, wherein the variant has an amino acid sequence which, when aligned with the alpha-amylase comprising the sequence set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue. Such a variant polypeptide may be used in the preparation of a baked product.Type: GrantFiled: September 26, 2017Date of Patent: June 25, 2019Assignee: DSM IP ASSETS B.V.Inventors: Rene Marcel De Jong, Hanna Elsabet Abbas, Evert Tjeerd Van Rij
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Publication number: 20190185830Abstract: The present invention relates to a polypeptide having lipase activity wherein the polypeptide, which, when aligned with a polypeptide according to SEQ ID NO: 1, comprises at least one amino acid substitution resulting in Ser (S), Ala (A) or Leu (L) at position 246, Trp (W) at position 307, Leu (L) at position 345, Ile (I) at position 365, and/or Phe (F) at position 534, wherein the position is defined with reference to SEQ ID NO: 1, wherein Ala(A) at position 1 in SEQ ID NO: 1 is counted as number 1 and a method for preparing the polypeptide. The present invention further relates to a process for preparing a food product wherein a polypeptide according to the present invention is used.Type: ApplicationFiled: June 8, 2017Publication date: June 20, 2019Inventors: Rene Marcel DE JONG, Willem BIJLEVELD, Evert Tjeerd VAN RIJ
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Patent number: 10316305Abstract: The invention relates to a polypeptide having hemicellulase activity. The invention features the full length coding sequence of the novel gene as well as the amino acid sequence of the full-length functional protein and functional equivalents of the gene or the amino acid sequence. The invention also relates to methods for using the polypeptide in industrial processes. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins.Type: GrantFiled: April 25, 2018Date of Patent: June 11, 2019Assignee: DSM IP ASSETS B.V.Inventors: Alrik Pieter Los, Rene Marcel De Jong, Maaike Appeldoorn
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Publication number: 20190161000Abstract: The invention describes a lighting assembly for use in a lighting arrangement of a vehicle. The lighting assembly includes a projection lens and a light source array, wherein a center of the light source array and an optical axis of the projection lens have a lateral offset, and light sources of the light source array are individually controllable to adjust a swivel angle of a light beam generated by that lighting assembly. The invention further describes a controller for controlling the light sources of such a lighting assembly. The invention also describes a lighting arrangement for a vehicle, comprising such a lighting assembly and such a controller for controlling the light sources of the lighting assembly to adjust the swivel angle of the light beam. The invention also describes a method of generating a front beam for a vehicle comprising such a lighting assembly.Type: ApplicationFiled: January 30, 2019Publication date: May 30, 2019Inventors: Marten Sikkens, Marcel De Jong, Silvia Maria Booij, Martinus Petrus Creusen
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Publication number: 20190136213Abstract: The invention relates to a polypeptide having hemicellulase activity which comprises the amino acid sequence set out in SEQ ID NO: 2, 7, 12, 17, 22, 27, 32, 37, 42, 47, 52, 57, 62, 67 or 72 or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 1, 6, 11, 16, 21, 26, 31, 36, 41, 46, 51, 56, 61, 66 or 71, SEQ ID NO: 4, 9, 14, 19, 24, 29, 34, 39, 44, 49, 54, 59, 64, 69 or 74, or a variant polypeptide or variant polynucleotide thereof, wherein the variant polypeptide has at least 75% sequence identity with the sequence set out in SEQ ID NO: 2, 7, 12, 17, 22, 27, 32, 37, 42, 47, 52, 57, 62, 67 or 72 or the variant polynucleotide encodes a polypeptide that has at least 75% sequence identity with the sequence set out in SEQ ID NO: 2, 7, 12, 17, 22, 27, 32, 37, 42, 47, 52, 57, 62, 67 or 72.Type: ApplicationFiled: January 17, 2019Publication date: May 9, 2019Inventors: Alrik Pieter LOS, Rene Marcel De Jong, Maaike Appeldoorn
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Patent number: 10273507Abstract: The invention relates to a cell capable of converting one or more pentose sugar and one or more hexose sugar into fermentation product constitutively expressing one or more heterologous or homologous polypeptide having the amino acid sequence set out in SEQ ID NO: 20, or a variant polypeptide thereof having at least 45% identity to SEQ ID NO 20. In an embodiment the heterologous polypeptide has glyoxalase activity.Type: GrantFiled: October 15, 2013Date of Patent: April 30, 2019Assignee: DSM IP ASSETS B.V.Inventors: Maria Bernedina Elizabeth Jonkers, Paul Klaassen, Aloysius Wilhelmus Rudolphus Hubertus Teunissen, Rene Marcel De Jong
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Patent number: 10253305Abstract: A variant polypeptide having chymosin activity, wherein the variant has an amino acid sequence which, when aligned with the chymosin comprising the sequence set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue corresponding to any of amino acids 2, 22, 40, 48, 50, 51, 53, 61, 62, 76, 88, 98, 99, 109, 112, 117, 125, 126, 135, 144, 160, 161, 163, 187, 189, 194, 200, 201, 202, 203, 221, 223, 240, 242, 244, 254, 267, 271, 273, 278, 280, 284, 289, 292, 294 or 295 said positions being defined with reference to SEQ ID NO: 2 and wherein the variant has one or more altered properties as compared with a reference polypeptide having chymosin activity. Such a variant polypeptide may be used in the preparation of a cheese.Type: GrantFiled: October 12, 2017Date of Patent: April 9, 2019Assignee: DSM IP ASSETS B.V.Inventors: Petrus Jacobus Theodorus Dekker, Rene Marcel De Jong, Cornelis Marinus Muijlwijk
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Patent number: 10227033Abstract: The invention describes a lighting assembly (10, 10?, 20, 20?) for use in a lighting arrangement (2) of a vehicle (1), comprising a projection lens (11, 21) and an array (12, 22) of light sources (S11, . . . , S26), wherein the projection lens (11, 21) and the light source array (12, 22) are arranged according to an asymmetry displacement (?i, ?2, di, d2) of the optical axis (X1, X2) of the projection lens (11, 21), and wherein the light sources (S11, . . . , S26) of the light source array (12, 22) of the lighting assembly (10, 10?, 20, 20?) are individually controllable to adjust a swivel angle (?1, ?2) of a light beam (BL, BH) generated by that lighting assembly (10, 10?, 20, 20?). The invention further describes a controller (3) for controlling the light sources (S11, . . . , S26) of such a lighting assembly (10, 10?, 20, 20?).Type: GrantFiled: March 11, 2011Date of Patent: March 12, 2019Assignee: Lumileds LLCInventors: Marten Sikkens, Marcel De Jong, Silvia Maria Booij, Martinus Petrus Creusen
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Patent number: 10167463Abstract: The invention relates to a polypeptide having chymosin activity which: a. is capable of hydrolyzing bovine alpha s1-casein at position F23F24 so as to form ?s1-I CN (f24-199) more rapidly than camel chymosin; and b. has a C/P ratio higher than the C/P ratio of bovine chymosin.Type: GrantFiled: May 3, 2013Date of Patent: January 1, 2019Assignee: DSM IP ASSETS B.V.Inventors: Petrus Jacobus Theodorus Dekker, Rene Marcel De Jong, Michael Dennis Tabeling, Cornelis Marinus Muijlwijk
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Publication number: 20180320156Abstract: The invention relates to a variant polypeptide having lactase activity. The invention also relates to a nucleic acid sequence encoding such a variant polypeptide, to a nucleic acid construct comprising said nucleic acid sequence, to a recombinant expression vector comprising said nucleic acid construct and to a recombinant host cell comprising said expression vector. Further, the invention relates to a method for producing a lactase variant via use of such a host cell. Also, the invention relates to a method of producing a lactase polypeptide variant. The invention further relates to a composition comprising a lactase variant, to use of such a lactase variant or to the use of a lactase variant-containing composition in the preparation of a dairy product, to a process for the production of a dairy product and to the resulting dairy product.Type: ApplicationFiled: May 4, 2018Publication date: November 8, 2018Inventors: René Marcel DE JONG, Ulrike Maria MÜLLER, Petrus Jacobus Theodorus DEKKER
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Patent number: 10100320Abstract: The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least 75% sequence identity to the amino acid sequence set out in SEQ ID NO: 2 and wherein the nucleotide sequence is heterologous to the host. A cell of the invention may be used in a process for producing a fermentation product, such as ethanol. Such a process may comprise fermenting a medium containing a source of xylose with a cell of the invention such that the cell ferments xylose to the fermentation product.Type: GrantFiled: June 2, 2017Date of Patent: October 16, 2018Assignee: DSM IP ASSETS B.V.Inventors: Paul Klaassen, Gijsberdina Pieternella Van Suylekom, Rene Marcel De Jong
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Publication number: 20180245059Abstract: The invention relates to a polypeptide having hemicellulase activity. The invention features the full length coding sequence of the novel gene as well as the amino acid sequence of the full-length functional protein and functional equivalents of the gene or the amino acid sequence. The invention also relates to methods for using the polypeptide in industrial processes. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins.Type: ApplicationFiled: April 25, 2018Publication date: August 30, 2018Inventors: Alrik Pieter LOS, Rene Marcel DE JONG, Maaike APPELDOORN
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Patent number: 10000537Abstract: The invention relates to a polypeptide having one or more substitution at a position corresponding to position 339 or 376 of SEQ ID NO: 59, wherein the polypeptide is a member of the Major Facilitator Superfamily (MFS). In an embodiment, the substitution is at position corresponding to 376 and wherein the amino acid at that position is replaced by an amino acid that has a van der Waals volume of 80 to 138 ?3 and a side chain hydrophobicity of 10 to 100 ?tR.Type: GrantFiled: June 4, 2014Date of Patent: June 19, 2018Assignee: DSM IP ASSETS B.V.Inventors: Paul Klaassen, Paulus Petrus De Waal, Rene Marcel De Jong, Arnold Jacob Mattieu Driessen, Jeroen Gerben Nijland, Hyun Yong Shin
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Patent number: 9994837Abstract: The invention relates to a variant polypeptide having lactase activity. The invention also relates to a nucleic acid sequence encoding such a variant polypeptide, to a nucleic acid construct comprising said nucleic acid sequence, to a recombinant expression vector comprising said nucleic acid construct and to a recombinant host cell comprising said expression vector. Further, the invention relates to a method for producing a lactase variant via use of such a host cell. Also, the invention relates to a method of producing a lactase polypeptide variant. The invention further relates to a composition comprising a lactase variant, to use of such a lactase variant or to the use of a lactase variant-containing composition in the preparation of a dairy product, to a process for the production of a dairy product and to the resulting dairy product.Type: GrantFiled: January 13, 2015Date of Patent: June 12, 2018Assignee: DSM IP ASSETS B.V.Inventors: René Marcel De Jong, Ulrike Maria Müller, Petrus Jacobus Theodorus Dekker
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Patent number: 9988615Abstract: The invention relates to a polypeptide having hemicellulase activity. The invention features the full length coding sequence of the novel gene as well as the amino acid sequence of the full-length functional protein and functional equivalents of the gene or the amino acid sequence. The invention also relates to methods for using the polypeptide in industrial processes. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins.Type: GrantFiled: February 3, 2014Date of Patent: June 5, 2018Assignee: DSM IP ASSETS B.V.Inventors: Alrik Pieter Los, Rene Marcel De Jong, Maaike Appeldoorn
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Publication number: 20180134986Abstract: The present invention relates to a polypeptide having phospholipase C activity, selected from the group consisting of i. a polypeptide comprising a mature polypeptide sequence of SEQ ID NO: 2; ii. a polypeptide that has least 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% identity to the mature polypeptide sequence of SEQ ID NO: 2; iii. a polypeptide encoded by a nucleic acid that hybridizes under medium stringency, preferably under high stringency conditions to the complementary strand of the mature polypeptide coding sequence of SEQ ID NO:1; iv. a polypeptide encoded by a nucleic acid that has at least 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% identity to the mature polypeptide coding sequence of SEQ ID NO: 1.Type: ApplicationFiled: April 8, 2016Publication date: May 17, 2018Applicant: DSM IP ASSETS B.V.Inventors: Arjen SEIN, Rene Marcel DE JONG, Evert Tjeerd VAN RIJ, Willem BIJLEVELD, Maarten Hotse WILBRINK
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Patent number: 9944905Abstract: The present invention relates to a variant polypeptide having fumarate reductase activity, which has modified NADP(H)-dependent and/or NAD(H)-dependent activity as compared with a reference polypeptide having fumarate reductase activity. Such a variant may be overexpressed in a host cell in order to improve production of a dicarboxylic acid.Type: GrantFiled: December 12, 2014Date of Patent: April 17, 2018Assignee: DSM IP ASSETS B.V.Inventors: René Marcel De Jong, Zheng Zhao, Ben Den Dulk, Remko Tsjibbe Winter
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Publication number: 20180030427Abstract: A variant polypeptide having chymosin activity, wherein the variant has an amino acid sequence which, when aligned with the chymosin comprising the sequence set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue corresponding to any of amino acids 2, 22, 40, 48, 50, 51, 53, 61, 62, 76, 88, 98, 99, 109, 112, 117, 125, 126, 135, 144, 160, 161, 163, 187, 189, 194, 200, 201, 202, 203, 221, 223, 240, 242, 244, 254, 267, 271, 273, 278, 280, 284, 289, 292, 294 or 295 said positions being defined with reference to SEQ ID NO: 2 and wherein the variant has one or more altered properties as compared with a reference polypeptide having chymosin activity. Such a variant polypeptide may be used in the preparation of a cheese.Type: ApplicationFiled: October 12, 2017Publication date: February 1, 2018Inventors: Petrus Jacobus Theodorus DEKKER, Rene Marcel De Jong, Cornelis Marinus Muijlwijk
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Publication number: 20180007917Abstract: A variant polypeptide having alpha-amylase activity, wherein the variant has an amino acid sequence which, when aligned with the alpha-amylase comprising the sequence set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue. Such a variant polypeptide may be used in the preparation of a baked product.Type: ApplicationFiled: September 26, 2017Publication date: January 11, 2018Inventors: Rene Marcel DE JONG, Hanna Elsabet ABBAS, Evert Tjeerd VAN RIJ
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Patent number: 9822352Abstract: A variant polypeptide having chymosin activity, wherein the variant has an amino acid sequence which, when aligned with the chymosin comprising the sequence set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue corresponding to any of amino acids 2, 22, 40, 48, 50, 51, 53, 61, 62, 76, 88, 98, 99, 109, 112, 117, 125, 126, 135, 144, 160, 161, 163, 187, 189, 194, 200, 201, 202, 203, 221, 223, 240, 242, 244, 254, 267, 271, 273, 278, 280, 284, 289, 292, 294 or 295 said positions being defined with reference to SEQ ID NO: 2 and wherein the variant has one or more altered properties as compared with a reference polypeptide having chymosin activity. Such a variant polypeptide may be used in the preparation of a cheese.Type: GrantFiled: May 3, 2013Date of Patent: November 21, 2017Assignee: DSM IP ASSETS B.V.Inventors: Petrus Jacobus Theodorus Dekker, Rene Marcel De Jong, Cornelis Marinus Muijlwijk