Patents by Inventor Marcel Descamps
Marcel Descamps has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6242607Abstract: The invention relates to glutarimides of formula (I): in which Ar represents a phenyl non substituted or substituted one or more times with one of the substituents selected from a halogen atom, a hydroxyl, a (C1-C4)alkoxy, a trifluoromethyl, a (C1-C4)alkyl, said substituents being identical or different; a pyridyl group; a thienyl group and X is methylene or ethylene, their salts and their enantiomers, as well as their method of preparation and their use for the preparation of the corresponding 3,3-disubstituted piperidines.Type: GrantFiled: November 10, 1999Date of Patent: June 5, 2001Assignee: Sanofi-SynthelaboInventors: Philippe Camus, Marcel Descamps, Joël Radisson
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Patent number: 6008360Abstract: The invention relates to glutarimides of formula (I): ##STR1## in which Ar represents a phenyl non substituted or substituted one or more times with one of the substitutents selected from a halogen atom, a hydroxyl, a (C.sub.1 -C.sub.4)alkoxy, a trifluoromethyl, a (C.sub.1 -C.sub.4)alkyl, said substitutents being identical or different ; a pyridyl group; a thienyl group and X is methylene or ethylene, their salts and their enantiomers, as well as their method of preparation and their use for the preparation of the corresponding 3,3-disubstituted piperidines.Type: GrantFiled: September 3, 1998Date of Patent: December 28, 1999Assignee: Sanofi-SynthelaboInventors: Philippe Camus, Marcel Descamps, Joel Radisson
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Patent number: 5780666Abstract: A process is described for the preparation of (+)-2-(3,4-dichlorophenyl)-4-hydroxybutylamine (I) by reaction of 3,4-dichlorophenylacetic acid (II) with an alkali metal halogenoacetate, treatment of the 3-cyano-3-(3,4-dichlorophenyl)propionic acid (III) with D-(-)-N-methylglucamine, with second-order asymmetric conversion, hydrolysis of the D-(-)-N-methylglucamine salt of (-)-3-cyano-3-(3,4-dichlorophenyl,)propionic acid and enantioconservative reduction of the resulting levorotatory cyanoacid with a borane.Type: GrantFiled: February 7, 1996Date of Patent: July 14, 1998Assignee: SanofiInventors: Marcel Descamps, Joel Radisson, Anne-Archard Gilles
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Patent number: 5512680Abstract: A process is described for the preparation of (+)-2-(3,4-dichlorophenyl)-4-hydroxybutylamine (I) by reaction of 3,4-dichlorophenylacetonitrile (II) with an alkali metal halogenoacetate, treatment of the 3-cyano-3-(3,4-dichlorophenyl)propionic acid (III) with D-(-)-N-methylglucamine, with second-order asymmetric conversion, hydrolysis of the D-(-)-N-methylglucamine salt of (-)-3-cyano-3-(3,4-dichlorophenyl)propionic acid and enantioconservative reduction of the resulting levorotatory cyanoacid with a borane.Type: GrantFiled: August 24, 1994Date of Patent: April 30, 1996Assignee: SanofiInventors: Marcel Descamps, Joel Radisson, Gilles Anne-Archard
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Patent number: 5215988Abstract: The present invention relates to aminoalkoxyphenyl compounds of formula: ##STR1## in which: B is selected from --S--, --SO-- and --SO.sub.2 --,R.sub.1 and R.sub.2, which are identical or different, are selected from hydrogen, methyl, ethyl and halogen,A is selected from a straight- or branched-alkylene radical having from 2 to 5 carbon atoms, a 2-hydroxypropylene radical, and a 2-(lower alkoxy) propylene radical,R.sub.3 is selected from C.sub.1 -C.sub.8 alkyl and a radical of formula:--Alk--Arin which Alk is selected from a single bond and a linear- or branched-alkylene radical having from 1 to 5 carbon atoms; and Ar is selected from pyridyl, phenyl, 2-3-methyleneoxyphenyl, 3,4-methylenedioxyphenyl and phenyl substituted with one or more substituents, which may be identical or different, selected from halogen atoms, C.sub.1 -C.sub.8 alkyl groups and C.sub.1 -C.sub.8 alkoxy groups,R.sub.4 is selected from hydrogen and C.sub.1 -C.sub.8 alkyl, orR.sub.3 and R.sub.Type: GrantFiled: August 14, 1991Date of Patent: June 1, 1993Assignee: SanofiInventors: Jean Gubin, Pierre Chatelain, Marcel Descamps, Dino Nisato, Henri Inion, Jean Lucchetti, Jean-Marie Mahaux, Jean-Noel Vallat
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Patent number: 5204469Abstract: The invention relates to a process for the preparation of the compound of formula ##STR1## wherein a formylating agent is reacted with the compound of formula ##STR2## and wherein the compounds obtained are cyclised in the presence of an acid.Type: GrantFiled: July 3, 1991Date of Patent: April 20, 1993Assignee: SanofiInventors: Marcel Descamps, Joel Radisson
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Patent number: 5182291Abstract: Aminoalkoxyphenyl derivatives useful in the treatment of certain pathological syndromes of the cardiovascular system of formula: ##STR1## in which: B represents a --S--, --SO-- or --SO.sub.2 -- group,R.sub.1 and R.sub.2, which are identical or different, each denote hydrogen, a methyl or ethyl radical or a halogen,A denotes a straight- or branched-alkylene radical having from 2 to 5 carbon atoms or a 2-hydroxypropylene radical, in which the hydroxy is optionally substituted by a lower alkyl radical,R.sub.3 denotes an alkyl radical or a radical of formula:--Alk--R.sub.5in which Alk denotes a single bond or a linear- or branched-alkylene radical having from 1 to 5 carbon atoms and R.sub.5 denotes a pyridyl, phenyl, 2,3-methylenedioxyphenyl or 3,4-methylenedioxyphenyl radical or a phenyl group substituted with one or more substituents, which may be identical or different, selected from halogen atoms, lower alkyl groups or lower alkoxy groups,R.sub.4 denotes hydrogen or an alkyl radical orR.sub.3 and R.sub.Type: GrantFiled: June 17, 1991Date of Patent: January 26, 1993Assignee: SanofiInventors: Jean Gubin, Pierre Chatelain, Marcel Descamps, Dino Nisato, Henri Inion, Jean Lucchetti, Jean-Marie Mahaux, Jean-Noel Vallat
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Patent number: 5039700Abstract: Aminoalkoxyphenyl derivatives useful in the treatment of certain pathological syndromes of the cardiovascular system of formula: ##STR1## in which: B represents a --S--, --SO-- or --SO.sub.2 -- group,R.sub.1 and R.sub.2, which are identical or different, each denote hydrogen, a methyl or ethyl radical or a halogen,A denotes a straight- or branched-alkylene radical having from 2 to 5 carbon atoms or a 2-hydroxypropylene radical, in which the hydroxy is optionally substituted by a lower alkyl radical,R.sub.3 denotes an alkyl radical or a radical of formula:--Alk--R.sub.5in which Alk denotes a single bond or a linear- or branched-alkylene radical having from 1 to 5 carbon atoms and R.sub.5 denotes a phenyl, 2,3-methylenedioxyphenyl or 3,4-methylenedioxyphenyl radical or a phenyl group substituted with one or more substituents, which may be identical or different, selected from halogen atoms, lower alkyl groups or lower alkoxy groups,R.sub.Type: GrantFiled: March 19, 1990Date of Patent: August 13, 1991Assignee: SanofiInventors: Jean Gubin, Pierre Chatelain, Marcel Descamps, Dino Nisato, Henri Inion, Jean Lucchetti, Jean-Marie Mahaux, Jean-Noel Vallat
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Patent number: 5017579Abstract: The present invention is directed to the use of aminoalkoxyphenyl derivatives for reducing and/or controlling excessive intraocular pressure and compositions suitable for this case.Type: GrantFiled: February 6, 1989Date of Patent: May 21, 1991Assignee: SanofiInventors: Jean Gubin, Pierre Chatelain, Marcel Descamps, Dino Nisato, Henri Inion, Jean Lucchetti, Jean-Marie Mahaux, Jean-Noel Vallat, Gerard Le Fur
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Patent number: 4977274Abstract: The invention relates to new 4-hydroxyindole derivatives of general formula: ##STR1## in which R represents a labile protective group and R.sub.1 can represent hydrogen, a C.sub.1 -C.sub.6 alkyl radical, a C.sub.3 -C.sub.6 cycloalkyl radical, a lower alkoxy radical, a lower hydroxyalkyl radical, a lower (lower alkoxy) alkyl radical, a phenyl radical optionally substituted with a halogen atom or a lower alkyl or lower alkoxy radical, a cyano radical, a radical of formula ##STR2## in which R.sub.2 and R.sub.3, which may be identical or different, each represent hydrogen or a lower alkyl radical, R.sub.4 represents a hydroxy group, a lower alkyl or lower alkoxy radical or a radical ##STR3## in which R.sub.2 and R.sub.3 have the same meaning as above, R.sub.5 represents a lower alkyl radical and Alk represents a single bond or a straight- or branched-chain alkylene radical having from 1 to 4 carbon atoms.Type: GrantFiled: August 28, 1989Date of Patent: December 11, 1990Assignee: SanofiInventors: Marcel Descamps, Walter Verstraeten
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Patent number: 4965401Abstract: The process for the preparation of the E isomers of the compounds of formula A: ##STR1## in which R.sub.1 is selected from H or C.sub.1 -C.sub.4 alkyl, comprises according to the invention the reaction of propionaldehyde with a phosphorus derivative of formula: ##STR2## in which R.sub.1 designates C.sub.1 -C.sub.4 alkyl and R.sub.2 is selected from C.sub.1 -C.sub.4 alkyl or phenyl, and, optionally, the hydrolysis of the compound of formula A in which R.sub.1 is alkyl in order to form the compounds of formula A in which R.sub.1 is H.Pharmaceutical industry.Type: GrantFiled: December 1, 1989Date of Patent: October 23, 1990Assignee: SanofiInventors: Marcel Descamps, Georges Sayac
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Patent number: 4957925Abstract: An aminoalkoxyphenyl compound of formula ##STR1## as well as a pharmaceutically acceptable salt of this compound.Type: GrantFiled: August 7, 1987Date of Patent: September 18, 1990Assignee: SanofiInventors: Jean Gubin, Pierre Chatelain, Marcel Descamps, Dino Nisato, Henri Inion, Jean Lucchetti, Jean-Marie Mahaux, Jean-Noel Vallat
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Patent number: 4816598Abstract: The invention relates to 4-amino-butanoic acid derivatives of general formula: ##STR1## in which: M represents an alkali metal atom,R represents a protected amino group,R.sub.1 represents a labile group,R.sub.2 represents hydrogen, a branched- or straight-chain alkyl radical having from 1 to 6 carbon atoms, a lower methyloxyalkyl, a lower methylthioalkyl, a lower (lower alkyl)-aminoalkyl, a lower di-(lower alkyl)-aminoalkyl or a lower hydroxyalkyl radical or R.sub.2 represents one of the radicals of general formulae:Cy--A--, Cy--O--A'--, R--A'-- or R.sub.Type: GrantFiled: June 16, 1987Date of Patent: March 28, 1989Assignee: SanofiInventors: Marcel Descamps, Walter Verstraeten
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Patent number: 4814485Abstract: The invention relates to new (4S)-4-aminobutanoic acid derivatives of general formula: ##STR1## in which: R represents an N-protective group,R.sub.1 represents hydrogen, an alkali metal atom such as lithium, sodium or potassium or a liabile group,R.sub.2 represents a group of formula: ##STR2## in which W represents hydrogen, a hydroxy group or an alkyl radical containing from 1 to 4 carbon atoms or an alkoxy radical containing from 1 to 4 carbon atoms, and to a process for the preparation of the said derivatives.The 4-aminobutanoic acid derivatives according to the invention are useful as synthesis intermediates for the preparation of peptides derived from statin analogues.Type: GrantFiled: December 2, 1986Date of Patent: March 21, 1989Assignee: SanofiInventors: Marcel Descamps, Dino Nisato, Walter Verstraeten
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Patent number: 4791137Abstract: Pharmaceutical and veterinary compositions having as essential active ingredient at least one benzofuran derivative of the general formula: ##STR1## or a pharmaceutically acceptable acid addition salt thereof in which R represents an amino, monoethylamino or diethylamino radical and X.sub.1 and X.sub.2 represent hydrogen or iodine with the proviso that when R represents diethylamino X.sub.1 and X.sub.2 are different.These compositions are useful for the treatment of ischemic cardiac disorders.Type: GrantFiled: December 2, 1986Date of Patent: December 13, 1988Assignee: SanofiInventors: Marcel Descamps, Yves Berger
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Patent number: 4661514Abstract: Pharmaceutical and veterinary compositions having as essential active ingredient at least one benzofuran derivative of the general formula: ##STR1## or a pharmaceutically acceptable acid addition salt thereof in which R represents an amino, monoethylamino or diethylamino radical and X.sub.1 and X.sub.2 represent hydrogen or iodine with the proviso that when R represents diethylamino X.sub.1 and X.sub.2 are different.These compositions are useful for the treatment of ischemic cardiac disorders.Type: GrantFiled: December 11, 1985Date of Patent: April 28, 1987Assignee: SanofiInventors: Marcel Descamps, Yves Berger
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Patent number: 4575513Abstract: Pharmaceutical and veterinary compositions having as essential active ingredient at least one benzofuran derivative of the general formula: ##STR1## or a pharmaceutically acceptable acid addition salt thereof in which R represents an amino, monoethylamino or diethylamino radical and X.sub.1 and X.sub.2 represent hydrogen or iodine with the proviso that when R represents diethylamino X.sub.1 and X.sub.2 are different.These compositions are useful for the treatment of ischemic cardiac disorders.Type: GrantFiled: July 5, 1984Date of Patent: March 11, 1986Assignee: SanofiInventors: Marcel Descamps, Yves Berger
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Patent number: 4565828Abstract: Benzofuran derivatives represented by the general formula: ##STR1## in which: R represents an ethyl, n-propyl, isopropyl or n-butyl radical;R.sub.1 represents a branched-chain alkyl radical having from 4 to 7 carbon atoms of which at least one does not bear a hydrogen atom;R.sub.2 represents hydrogen, chlorine or bromine;n is 1 or 2and pharmaceutically acceptable acid addition salts thereof.These derivatives have been found to possess calcium translocation inhibiting properties and antiadrenergic properties and can thus be used in the treatment of certain pathological syndromes of the cardiovascular system.Type: GrantFiled: July 5, 1984Date of Patent: January 21, 1986Assignee: SanofiInventors: Marcel Descamps, Peter Polster
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Patent number: 4374841Abstract: Novel pyridoxine derivatives represented by the general formula: ##STR1## in which: R represents a radical ##STR2## --CH.sub.2 --(CH.sub.2).sub.n --CH.sub.2 --OR.sub.2 or ##STR3## in which n represents 0 or 1, X and X.sub.1, which are different, represent hydrogen or methyl, Y represents hydrogen or methyl and R.sub.2 represents a phenyl group non-substituted or bearing one or two substituents selected from the group consisting of fluorine, chlorine and bromine and of the radicals methyl, ethyl, n-propyl, isopropyl and methoxy,R.sub.1 represents hydrogen or a radical of formula ##STR4## in which R.sub.3 represents a straight-chain alkyl radical having from 1 to 4 carbon atoms and pharmaceutically acceptable acid addition salts thereof.These compounds present .alpha.-antiadrenergic properties some of them also presenting .beta.-antiadrenergic, antihypertensive and central depressant effects.Type: GrantFiled: May 11, 1981Date of Patent: February 22, 1983Assignee: S. A. Labaz N.V.Inventors: Marcel Descamps, Marcel Urbain, deceased, Claire Urbain, legal representative, Jacques J. Z. Urbain, legal representative, Jean P. M. C. Urbain, legal representative, Nadine C. J. Urbain, legal representative
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Patent number: D955232Type: GrantFiled: May 8, 2020Date of Patent: June 21, 2022Assignee: DESCAMPS.TECHNOLOGY LIMITEDInventors: Marcel Descamps Frédéric, Yat Chiu Chan, Ban Poh Michael Ong, Tak Man Cheng