Abstract: A device for in-vitro modelling in-vivo tissues of organs that includes a device for in-vitro modelling in-vivo tissues of organs, the device including an open access chamber, a perfusion channel, and a culturing membrane dividing the access chamber from the perfusion channel, wherein the culturing membrane is porous and flexible and/or elastic.

Abstract: A device for in-vitro modelling in-vivo tissues of organs that includes a first body portion with at least one access chamber, a second body portion with at least one culturing chamber, and a culturing membrane dividing the at least one access chamber from the culturing chamber. The device further includes a third body portion with at least one actuation chamber having at least one limitation cavity, and an actuation membrane dividing the at least one culturing chamber from the at least one actuation chamber. With the device, a robust actuation system can be provided that does not depend on the mechanical properties of the actuation membrane material, nor on the pressure, and that allows to mimic three-dimensional deformations of the tissue, in particular of lung alveoli.

Abstract: A packaging line implemented for packaging a pre-filled syringe is disclosed having a NSD mounting station, a PFS delivery arrangement adapted to automatically deliver a pre-filled syringe to the NSD mounting station, and a NSD delivery arrangement adapted to automatically deliver a needle safety device to the NSD mounting station. The NSD mounting station is arranged to automatically assemble the needle safety device to the pre-filled syringe. A NSD visual inspection station is adapted to automatically identify a pre-filled syringe with an unfit needle safety device and to automatically eliminate the identified pre-filled syringe from the packaging line. A re-insertion station is further provided to receive a pre-filled syringe with a needle safety device and to automatically feed the received pre-filled syringe, preferably from a rejected secondary packaging, back into the packaging line, after the NSD mounting station and before the NSD visual inspection station.

Abstract: A packaging line implemented for packaging a pre-filled syringe is disclosed having a NSD mounting station, a PFS delivery arrangement adapted to automatically deliver a pre-filled syringe to the NSD mounting station, and a NSD delivery arrangement adapted to automatically deliver a needle safety device to the NSD mounting station. The NSD mounting station is arranged to automatically assemble the needle safety device to the pre-filled syringe. A NSD visual inspection station is adapted to automatically identify a pre-filled syringe with an unfit needle safety device and to automatically eliminate the identified pre-filled syringe from the packaging line. A re-insertion station is further provided to receive a pre-filled syringe with a needle safety device and to automatically feed the received pre-filled syringe, preferably from a rejected secondary packaging, back into the packaging line, after the NSD mounting station and before the NSD visual inspection station.

Abstract: A device for in-vitro modelling in-vivo tissues of organs that includes a first body portion with at least one access chamber, a second body portion with at least one culturing chamber, and a culturing membrane dividing the at least one access chamber from the culturing chamber. The device further includes a third body portion with at least one actuation chamber having at least one limitation cavity, and an actuation membrane dividing the at least one culturing chamber from the at least one actuation chamber. With the device, a robust actuation system can be provided that does not depend on the mechanical properties of the actuation membrane material, nor on the pressure, and that allows to mimic three-dimensional deformations of the tissue, in particular of lung alveoli.

Abstract: A device for in-vitro modelling in-vivo tissues of organs that includes a first body portion with at least one access chamber, a second body portion with at least one culturing chamber, and a culturing membrane dividing the at least one access chamber from the culturing chamber. The device further includes a third body portion with at least one actuation chamber having at least one limitation cavity, and an actuation membrane dividing the at least one culturing chamber from the at least one actuation chamber. With the device, a robust actuation system can be provided that does not depend on the mechanical properties of the actuation membrane material, nor on the pressure, and that allows to mimic three-dimensional deformations of the tissue, in particular of lung alveoli.

Abstract: A device (201) for in-vitro modelling in-vivo tissues of organs, comprises: a first body portion (207) with at least one access chamber (213), a second body portion (205) with at least one culturing chamber (221), and a culturing membrane (206) dividing the at least one access chamber (213) from the culturing chamber (221). The device further comprises a third body portion (203) with at least one actuation chamber (220) having at least one limitation cavity, and an actuation membrane (204) dividing the at least one culturing chamber (221) from the at least one actuation chamber (220). With the device according to the invention a robust actuation system can be provided that does not depend on the mechanical properties of the actuation membrane material, nor on the pressure, and that allows to mimic three-dimensional deformations of the tissue, in particular of lung alveoli.

Abstract: The invention involves a procedure for the catalytic enantioselective reduction of ketones to chiral alcohols. Heretofore, this reaction was carried out batch-wise. Because, in this procedure, one utilizes a catalyst increased in size with polymer, it is possible to carry out the reaction in a quasi-continuous manner in a membrane reactor. In contrast to the state of the art, one thus dramatically increases the operative life of the catalyst.