Abstract: The disclosure relates to compounds that act as inhibitors of epidermal growth factor receptor (EGFR); pharmaceutical compositions comprising the compounds; and methods of treating or preventing kinase-mediated disorders, including cancer and other proliferation diseases.

Abstract: The present invention relates to specific compounds for use in the prevention or treatment of viral infections caused by RNA viruses.

Abstract: A method for collision avoidance between a vulnerable road user transportation vehicle and a surrounding transportation vehicle. The user of the vulnerable road user transportation vehicle makes use of a portable communication device. Since such vulnerable road users are often involved in accidents since they are not easily recognized in the traffic, the disclosure increases safety for these vulnerable road users. The method includes transferring position detecting sensor data or derived position data of the vulnerable road user transportation vehicle to the portable communication device which performs a map matching technique for refining the position data and transfers the refined position data to the vulnerable road user transportation vehicle. The vulnerable road user transportation vehicle distributes the refined position data to the surrounding transportation vehicles which calculate a trajectory for the vulnerable road user transportation vehicle and estimate the risk of a collision.

Abstract: The invention relates to a method for stopping a self-driving vehicle (10), starting with determining an approach of the vehicle (10) to a specified stopping point (83). In addition, at least one moving object (70) is detected within the environment of the vehicle. A projected trajectory (84) of the vehicle (10) and a projected trajectory (85) of the object (70) at a first point in time t1 are determined. Based on the projected trajectory (84) of the vehicle (10), a second point in time t2 is then determined, at which the vehicle (10) arrives at the specified stopping point (83). Based on the position and speed of the object (70) at the second point in time t2 determined on the basis of the projected trajectory (85) of the object (70), a collision probability between the object (70) and a door (15) or a passenger of the vehicle (10) at the specified stopping point (83) at the second point in time t2 is determined.

Abstract: A method for collision avoidance between a vulnerable road user transportation vehicle and a surrounding transportation vehicle. The user of the vulnerable road user transportation vehicle makes use of a portable communication device. Since such vulnerable road users are often involved in accidents since they are not easily recognized in the traffic, the disclosure increases safety for these vulnerable road users. The method includes transferring position detecting sensor data or derived position data of the vulnerable road user transportation vehicle to the portable communication device which performs a map matching technique for refining the position data and transfers the refined position data to the vulnerable road user transportation vehicle. The vulnerable road user transportation vehicle distributes the refined position data to the surrounding transportation vehicles which calculate a trajectory for the vulnerable road user transportation vehicle and estimate the risk of a collision.