Patents by Inventor Marcel Garcia
Marcel Garcia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250144222Abstract: New conjugates having a general formula (I). The conjugates include at least one mannose 6-phosphate analogue targeting the cation-independent mannose 6-phosphate receptor and an antibody or antibody fragment for binding a specific target antigen or target molecule. Also, a process for preparing the conjugates and their medical use, in therapeutic or diagnostic fields. The conjugates of formula (I) are particularly interesting for use as a medicine, particularly in a therapeutic treatment method in which a therapeutic antibody or a therapeutic antibody fragment is administered.Type: ApplicationFiled: February 14, 2023Publication date: May 8, 2025Applicant: NANOMEDSYNInventors: Marcel GARCIA, Marie MAYNADIER, Ilaria BASILE, Khaled EL CHEIKH, Morgane DAURAT, Corentin GAUTHIER
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Patent number: 11638808Abstract: The scope of the invention encompasses novel, multifunctional tools for maintaining the neovagina. The tools comprise novel dilator shapes that conform the anatomical pathway of the neovagina. The tools may further include a douching function for the effective and thorough washing of the neovagina, which is not achieved with standard douching devices. The tools may also comprise a measurement function for medical evaluation of the neovagina and to aid in proper dilation. Also presented herein are novel devices for delivery of agents to the natal vagina, including insemination devices.Type: GrantFiled: November 14, 2017Date of Patent: May 2, 2023Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventor: Maurice Marcel Garcia
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Patent number: 11376151Abstract: Provided herein are medical drainage systems comprising structures to prevent blockages within drainage tubing, especially medical drainage tubing, for example caused by debris or airlocks. The novel systems of the invention employ, in some embodiments, elements of the Archimedian screw. The Archimedian screw elements comprise a rotating conveyer present in the tubing which promotes continuous flow of material through the tubing and prevents the formation of dependent loops and other blockages. The systems of the invention may be employed in diverse contexts, including urinary catheter drainage systems and thoracostamy systems. The systems of the invention, being gravity independent, may also be employed for the drainage or a movement of materials in space and other low gravity environments.Type: GrantFiled: November 13, 2015Date of Patent: July 5, 2022Inventor: Maurice Marcel Garcia
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Patent number: 11032993Abstract: A novel maize variety designated X90N370 and seed, plants and plant parts thereof are produced by crossing inbred maize varieties. Methods for producing a maize plant by crossing hybrid maize variety X90N370 with another maize plant are disclosed. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X90N370 through backcrossing or genetic transformation, and to the maize seed, plant and plant part produced thereby are described. Maize variety X90N370, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X90N370 are provided. Methods for producing maize varieties derived from maize variety X90N370 and methods of using maize variety X90N370 are disclosed.Type: GrantFiled: July 12, 2019Date of Patent: June 15, 2021Inventors: Martin Arbelbide, Dennis James Dolan, Gustavo Marcel Garcia, Christopher Michael Schaefer
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Patent number: 11021496Abstract: The present invention relates to mesoporous organosilica nanoparticles, the method of preparation thereof, and uses of the same in treatment by means of photodynamic therapy or in imaging.Type: GrantFiled: January 18, 2017Date of Patent: June 1, 2021Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE MONTPELLIER, NANOMEDSYNInventors: Jean Olivier Durand, Jimenez Chiara Mauriello, Sebastien Richeter, Laurence Raehm, Magali Gary-Bobo, Marcel Garcia, Marie Maynadier
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Publication number: 20200140466Abstract: The present invention relates to mesoporous organoslica nanoparticles, the method of preparation thereof, and uses of the same in treatment by means of photodynamic therapy or in imaging.Type: ApplicationFiled: January 18, 2017Publication date: May 7, 2020Inventors: Jean Olivier DURAND, Jimenez Chiara MAURIELLO, Sebastien RICHETER, Laurence RAEHM, Magali GARY-BOBO, Marcel GARCIA, Marie MAYNADIER
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Publication number: 20200054868Abstract: The scope of the invention encompasses novel, multifunctional tools for maintaining the neovagina. The tools comprise novel dilator shapes that conform the anatomical pathway of the neovagina. The tools may further include a douching function for the effective and thorough washing of the neovagina, which is not achieved with standard douching devices. The tools may also comprise a measurement function for medical evaluation of the neovagina and to aid in proper dilation. Also presented herein are novel devices for delivery of agents to the natal vagina, including insemination devices.Type: ApplicationFiled: November 14, 2017Publication date: February 20, 2020Applicant: The Regents of the University of CaliforniaInventor: Maurice Marcel Garcia
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Patent number: 9694074Abstract: Disclosed are nanovectors of formula (I) that can be used simultaneously for the targeting, imaging and treatment, by photodynamic therapy, of cancer cells, and to biodegradable silicon nanoparticles containing a variety of photosensitizing molecules, in particular porphyrins, capable of targeting diseased cells and inducing cell death by excitation in the near-infrared region (>600 nm) in monophotonic and biphotonic modes. In formula (I), (AA) is a porous silicon nanoparticle.Type: GrantFiled: March 26, 2013Date of Patent: July 4, 2017Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIERInventors: Frederique Cunin, Jean-Olivier Durand, Michael J. Sailor, Marcel Garcia, Emilie Secret, Magali Gary-Bobo, Marie Maynadier, Alain Morere
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Publication number: 20170029898Abstract: The invention relates to a method for the in vitro diagnosis of prostate cancer in a patient, characterised in that it comprises a step of measuring the expression level of the gene of the cation-independent mannose-6-phosphate receptor (CI-M6PR) in a sample of prostate tissue of the patient, the determination of overexpression of said CI-M6PR gene indicating the presence of prostate cancer in said patient.Type: ApplicationFiled: January 22, 2015Publication date: February 2, 2017Inventors: Marcel GARCIA, Ophélie VAILLANT, Xavier REBILLARD, Catherine MAZEROLLES, Magali GARY-BOBO, Alain MORERE
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Publication number: 20160135982Abstract: Provided herein are medical drainage systems comprising structures to prevent blockages within drainage tubing, especially medical drainage tubing, for example caused by debris or airlocks. The novel systems of the invention employ, in some embodiments, elements of the Archimedian screw. The Archimedian screw elements comprise a rotating conveyer present in the tubing which promotes continuous flow of material through the tubing and prevents the formation of dependent loops and other blockages. The systems of the invention may be employed in diverse contexts, including urinary catheter drainage systems and thoracostamy systems. The systems of the invention, being gravity independent, may also be employed for the drainage or a movement of materials in space and other low gravity environments.Type: ApplicationFiled: November 13, 2015Publication date: May 19, 2016Inventor: Maurice Marcel Garcia
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Patent number: 9061069Abstract: The invention relates to the use of oligomers having constrained dipeptide or tripeptide motifs as agents for the vectorization of active ingredients.Type: GrantFiled: August 2, 2010Date of Patent: June 23, 2015Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE MONTPELLIER 1, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)Inventors: Muriel Amblard, Jean Martinez, Lubomir Vezenkov, Jean-Francois Hernandez, Marcel Garcia, Marie Maynadier
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Publication number: 20150087050Abstract: Disclosed are nanovectors of formula (I) that can be used simultaneously for the targeting, imaging and treatment, by photodynamic therapy, of cancer cells, and to biodegradable silicon nanoparticles containing a variety of photosensitizing molecules, in particular porphyrins, capable of targeting diseased cells and inducing cell death by excitation in the near-infrared region (>600 nm) in monophotonic and biphotonic modes. In formula (I), (AA) is a porous silicon nanoparticle.Type: ApplicationFiled: March 26, 2013Publication date: March 26, 2015Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, ECOLE NATIONAL SUPERIEURE DE CHIMIE DE MONTPELLIERInventors: Frederique Cunin, Jean-Olivier Durand, Michael J. Sailor, Marcel Garcia, Emilie Secret, Magali Gary-Bobo, Marie Maynadier, Alain Morere
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Patent number: 8962573Abstract: The invention relates to conjugates of products of interest including glycoproteins, nanoparticles, and imaging agents and of compounds of the general formula (1): that target the cation-independent mannose 6-phosphate receptor with a high affinity. The invention also relates to their applications, for instance in enzyme replacement therapies.Type: GrantFiled: July 2, 2010Date of Patent: February 24, 2015Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), Centre National de la Recherche Scientifique—CNRS, Universite de Montpellier 1, Universite de Montpellier 2 Sciences et TechniquesInventors: Marcel Garcia, Alain Morere, Magali Gary-Bobo, Martine Cerutti, Khaled El Cheikh, Ilaria Basile, Philippe Nirde
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Patent number: 8709747Abstract: The invention relates to compounds of formula (I) wherein the groups A and B represent independently from each other —CH?CH—, or —C?C—, the terms t, u, v, w represent, independently from each other, values ranging from 0 to 9, the groups Y1 and Y2 can represent independently from each other an alkyl group (linear, branched or substituted) carrying from 1 to 9 carbon atoms, the groups Z1, Z2, Z3, and Z4 can represent independently from each other a chemically reactive group W, such as OH, NH2, SH, the groups Z5 and Z6 represent independently from each other a hydrogen atom, silica nanoparticles functionalized by these compounds, and their use as drugs.Type: GrantFiled: December 7, 2010Date of Patent: April 29, 2014Assignees: Centre National de la Recherche Scientifique, Universite de Rennes 1, I.N.S.E.R.M. (Institut National de la Sante et de la Recherche Medicale), Universite Montpellier 2 Sciences et TechniquesInventors: David Brevet, Laurence Raehm, Mireille Blanchard-Desce, Olivier Mongin, Magali Gary-Bobo-Sable-Teychene, Marcel Garcia, Alain Morere, Jean-Olivier Durand
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Patent number: 8425879Abstract: Nanovectors are disclosed that make it possible to simultaneously target, image, and treat cancerous cells using photodynamic therapy. Also disclosed are novel molecules (I) derived from porphyrins, silica-based nanoparticles comprising the same, and their use in photodynamic therapy.Type: GrantFiled: September 14, 2009Date of Patent: April 23, 2013Assignees: Centre National de la Recherche Scientifique, Institut Curie, Universite Mouloud Mammeri, Universite Montpellier 2Inventors: David Brevet, Ouahiba Hocine, Jean-Olivier Durand, Philippe Maillard, Alain Morere, Marcel Garcia, Monique Smaïhi, Magali Gary-Bobo
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Publication number: 20130065849Abstract: The invention relates to compounds of formula (I) wherein the groups A and B represent independently from each other —CH?CH—, or —C?C—, the terms t, u, v, w represent, independently from each other, values ranging from 0 to 9, the groups Y1 and Y2 can represent independently from each other an alkyl group (linear, branched or substituted) carrying from 1 to 9 carbon atoms, the groups Z1, Z2, Z3, and Z4 can represent independently from each other a chemically reactive group W, such as OH, NH2, SH, the groups Z5 and Z6 represent independently from each other a hydrogen atom, silica nanoparticles functionalized by these compounds, and their use as drugs.Type: ApplicationFiled: December 7, 2010Publication date: March 14, 2013Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES, UNIVERSITE DE RENNES 1Inventors: David Brevet, Laurence Raehm, Mireille Blanchard-Desce, Olivier Mongin, Magali Gary-Bobo-Sable-Teychene, Marcel Garcia, Alain Morere, Jean-Olivier Durand
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Publication number: 20120184480Abstract: The invention relates to the use of oligomers having constrained dipeptide or tripeptide motifs as agents for the vectorization of active ingredients.Type: ApplicationFiled: August 2, 2010Publication date: July 19, 2012Applicants: UNIVERSITE DE MONTPELLIER I, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Muriel Amblard, Jean Martinez, Lubomir Vezenkov, Jean-Francois Hernandez, Marcel Garcia, Marie Maynadier
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Publication number: 20120093795Abstract: The invention relates to conjugates of products of interest and of compounds targeting the cation-independent mannose 6-phosphate receptor with a high affinity. The invention also relates to their applications, for instance in enzyme replacement therapies.Type: ApplicationFiled: July 2, 2010Publication date: April 19, 2012Applicants: INSERM (Institut National de la Sante et de la Recherche Medicale), UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES, UNIVERSITE DE MONTPELLIER 1, Centre National de la Recherche Scientifique-CNRSInventors: Marcel Garcia, Alain Morere, Magali Gary-Bobo, Martine Cerutti, Khaled El Cheikh, Ilaria Basile, Philippe Nirde
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Publication number: 20110262357Abstract: Nanovectors are disclosed that make it possible to simultaneously target, image, and treat cancerous cells using photodynamic therapy. Also disclosed are novel molecules (I) derived from porphyrins, silica-based nanoparticles comprising the same, and their use in photodynamic therapy.Type: ApplicationFiled: September 14, 2009Publication date: October 27, 2011Inventors: David Brevet, Ouahiba Hocine, Jean-Olivier Durand, Philippe Maillard, Alain Morere, Marcel Garcia, Monique Smaïhi, Magali Gary-Bobo
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Patent number: 4795230Abstract: In order to spread optical fibers emerging from an end of cable and to firmly attach the cable end with ends of protective jackets in which the spread fibers are strung, the following steps are performed by means a spreading device including mainly a grooved hollow distributor. The distributor is fastened to a sawn off end of a grooved elongated ring in the cable by pinching a central armature emerging from the cable, by jaws housed in the distributor. A split ring is strung around a grooved revolution portion of the distributor. For each fiber, a longitudinal slot of the split ring and a respective groove of the revolution portion are superposed, the end of the jacket of the fiber is entered into the groove through the slot, and the jacket is forced into the groove by partially rotating the split ring so as to superpose the slot and another distributor groove.Type: GrantFiled: April 14, 1987Date of Patent: January 3, 1989Assignees: SAT (Societe Anonyme De Telecommunications, SILEC (Societe Industrielle De Liaisons Electriques)Inventors: Marcel Garcia, Didier Suillerot