Abstract: In some embodiments, an electronic device displays an incoming call user interface in response to receiving an indication of an incoming call. In some embodiments, the incoming call user interface is displayed overlaid on a respective user interface that is optionally associated with an application other than the application associated with the incoming call.

Abstract: A method includes, at a computer system with a display and a housing, while a call is ongoing between the computer system and a remote device, detecting a coupling of a case to the computer system, and in response to detecting the coupling of the case to the computer system, in accordance with a determination that the computer system is operating in a first audio mode, continuing the call, and, in accordance with a determination that the computer system is operating in a second audio mode different than the first audio mode, terminating the call.

Abstract: The scope of the invention encompasses novel, multifunctional tools for maintaining the neovagina. The tools comprise novel dilator shapes that conform the anatomical pathway of the neovagina. The tools may further include a douching function for the effective and thorough washing of the neovagina, which is not achieved with standard douching devices. The tools may also comprise a measurement function for medical evaluation of the neovagina and to aid in proper dilation. Also presented herein are novel devices for delivery of agents to the natal vagina, including insemination devices.

Abstract: Provided herein are medical drainage systems comprising structures to prevent blockages within drainage tubing, especially medical drainage tubing, for example caused by debris or airlocks. The novel systems of the invention employ, in some embodiments, elements of the Archimedian screw. The Archimedian screw elements comprise a rotating conveyer present in the tubing which promotes continuous flow of material through the tubing and prevents the formation of dependent loops and other blockages. The systems of the invention may be employed in diverse contexts, including urinary catheter drainage systems and thoracostamy systems. The systems of the invention, being gravity independent, may also be employed for the drainage or a movement of materials in space and other low gravity environments.

Abstract: A novel maize variety designated X90N370 and seed, plants and plant parts thereof are produced by crossing inbred maize varieties. Methods for producing a maize plant by crossing hybrid maize variety X90N370 with another maize plant are disclosed. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X90N370 through backcrossing or genetic transformation, and to the maize seed, plant and plant part produced thereby are described. Maize variety X90N370, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X90N370 are provided. Methods for producing maize varieties derived from maize variety X90N370 and methods of using maize variety X90N370 are disclosed.

Abstract: The present invention relates to mesoporous organosilica nanoparticles, the method of preparation thereof, and uses of the same in treatment by means of photodynamic therapy or in imaging.

Abstract: The present invention relates to mesoporous organoslica nanoparticles, the method of preparation thereof, and uses of the same in treatment by means of photodynamic therapy or in imaging.

Abstract: The scope of the invention encompasses novel, multifunctional tools for maintaining the neovagina. The tools comprise novel dilator shapes that conform the anatomical pathway of the neovagina. The tools may further include a douching function for the effective and thorough washing of the neovagina, which is not achieved with standard douching devices. The tools may also comprise a measurement function for medical evaluation of the neovagina and to aid in proper dilation. Also presented herein are novel devices for delivery of agents to the natal vagina, including insemination devices.

Abstract: Disclosed are nanovectors of formula (I) that can be used simultaneously for the targeting, imaging and treatment, by photodynamic therapy, of cancer cells, and to biodegradable silicon nanoparticles containing a variety of photosensitizing molecules, in particular porphyrins, capable of targeting diseased cells and inducing cell death by excitation in the near-infrared region (>600 nm) in monophotonic and biphotonic modes. In formula (I), (AA) is a porous silicon nanoparticle.

Abstract: The invention relates to a method for the in vitro diagnosis of prostate cancer in a patient, characterised in that it comprises a step of measuring the expression level of the gene of the cation-independent mannose-6-phosphate receptor (CI-M6PR) in a sample of prostate tissue of the patient, the determination of overexpression of said CI-M6PR gene indicating the presence of prostate cancer in said patient.

Abstract: Provided herein are medical drainage systems comprising structures to prevent blockages within drainage tubing, especially medical drainage tubing, for example caused by debris or airlocks. The novel systems of the invention employ, in some embodiments, elements of the Archimedian screw. The Archimedian screw elements comprise a rotating conveyer present in the tubing which promotes continuous flow of material through the tubing and prevents the formation of dependent loops and other blockages. The systems of the invention may be employed in diverse contexts, including urinary catheter drainage systems and thoracostamy systems. The systems of the invention, being gravity independent, may also be employed for the drainage or a movement of materials in space and other low gravity environments.

Abstract: The invention relates to the use of oligomers having constrained dipeptide or tripeptide motifs as agents for the vectorization of active ingredients.

Abstract: Disclosed are nanovectors of formula (I) that can be used simultaneously for the targeting, imaging and treatment, by photodynamic therapy, of cancer cells, and to biodegradable silicon nanoparticles containing a variety of photosensitizing molecules, in particular porphyrins, capable of targeting diseased cells and inducing cell death by excitation in the near-infrared region (>600 nm) in monophotonic and biphotonic modes. In formula (I), (AA) is a porous silicon nanoparticle.

Abstract: The invention relates to conjugates of products of interest including glycoproteins, nanoparticles, and imaging agents and of compounds of the general formula (1): that target the cation-independent mannose 6-phosphate receptor with a high affinity. The invention also relates to their applications, for instance in enzyme replacement therapies.

Abstract: The invention relates to compounds of formula (I) wherein the groups A and B represent independently from each other —CH?CH—, or —C?C—, the terms t, u, v, w represent, independently from each other, values ranging from 0 to 9, the groups Y1 and Y2 can represent independently from each other an alkyl group (linear, branched or substituted) carrying from 1 to 9 carbon atoms, the groups Z1, Z2, Z3, and Z4 can represent independently from each other a chemically reactive group W, such as OH, NH2, SH, the groups Z5 and Z6 represent independently from each other a hydrogen atom, silica nanoparticles functionalized by these compounds, and their use as drugs.

Abstract: Nanovectors are disclosed that make it possible to simultaneously target, image, and treat cancerous cells using photodynamic therapy. Also disclosed are novel molecules (I) derived from porphyrins, silica-based nanoparticles comprising the same, and their use in photodynamic therapy.

Abstract: The invention relates to compounds of formula (I) wherein the groups A and B represent independently from each other —CH?CH—, or —C?C—, the terms t, u, v, w represent, independently from each other, values ranging from 0 to 9, the groups Y1 and Y2 can represent independently from each other an alkyl group (linear, branched or substituted) carrying from 1 to 9 carbon atoms, the groups Z1, Z2, Z3, and Z4 can represent independently from each other a chemically reactive group W, such as OH, NH2, SH, the groups Z5 and Z6 represent independently from each other a hydrogen atom, silica nanoparticles functionalized by these compounds, and their use as drugs.

Abstract: The invention relates to the use of oligomers having constrained dipeptide or tripeptide motifs as agents for the vectorization of active ingredients.

Abstract: The invention relates to conjugates of products of interest and of compounds targeting the cation-independent mannose 6-phosphate receptor with a high affinity. The invention also relates to their applications, for instance in enzyme replacement therapies.