Patents by Inventor Marcel Jaspars

Marcel Jaspars has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200253929
    Abstract: The present invention discloses pseurotins and azaspirofurans and their use in the treatment and prevention in epilepsy and other seizures. The present invention further discloses methods to screen pseurotin- and azaspirofuran-like molecules as pharmaceutically active compounds.
    Type: Application
    Filed: August 28, 2018
    Publication date: August 13, 2020
    Inventors: Daniëlle Copmans, Peter De Witte, Rainer Ebel, Marcel Jaspars, Annelii Ny, Mostafa Rateb, Alan Smith, Jioji Tabudravu
  • Patent number: 10647977
    Abstract: This invention relates to an engineered leader-independent heterocyclase (also known as a cyclodehydratase) comprising a defined cyanobactin leader sequence which drives the efficient conversion of heterocyclisable amino acids, such as Ser, Thr and Cys, within a peptide substrate lacking a leader sequence into heterocycles produce a homogenous heterocycle-containing product. This may be useful in biotechnology and chemical synthesis.
    Type: Grant
    Filed: November 4, 2015
    Date of Patent: May 12, 2020
    Assignees: THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN, THE UNIVERSITY COURT OF THE UNIVERSITY OF ST. ANDREWS
    Inventors: James Naismith, Jesko Koehnke, Andrew Bent, Nicholas Westwood, Greg Mann, Wael Houssen Ibrahim, Marcel Jaspars, Ying Ge
  • Patent number: 10494657
    Abstract: This invention relates to the in vitro production of cyclic peptides using cyanobacterial enzymes, such as patellamide biosynthesis enzymes. Linear peptide substrates are cyclized using an isolated cyanbacterial macrocyclase, such as PatG from Prochloron spp. Before cyclization, residues in the linear peptide substrates may be heterocyclized using isolated cyanbacterial heterocyclasses, such as PatD or TruD heterocyclase. Methods of the invention may be useful, for example, for the production of cyclic peptidyl molecules, including cyclotides, such as katalas, and cyanobactins, such as patellamides and telomestatins, for example for use in the development of therapeutics.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: December 3, 2019
    Assignee: Oxford University Innovation Limited
    Inventors: Wael Houssen Ibrahim, Marcel Jaspars, Margaret Smith, James Naismith, Jesko Koehnke, Andrew Bent, Nicholas Westwood
  • Publication number: 20180179570
    Abstract: This invention relates to the in vitro production of cyclic peptides using cyanobacterial enzymes, such as patellamide biosynthesis enzymes. Linear peptide substrates are cyclized using an isolated cyanbacterial macrocyclase, such as PatG from Prochloron spp. Before cyclisation, residues in the linear peptide substrates may be heterocyclised using isolated cyanbacterial heterocyclasses, such as PatD or TruD heterocyclase. Methods of the invention may be useful, for example, for the production of cyclic peptidyl molecules, including cyclotides, such as katalas, and cyanobactins, such as patellamides and telomestatins, for example for use in the development of therapeutics.
    Type: Application
    Filed: August 22, 2017
    Publication date: June 28, 2018
    Inventors: Wael Houssen Ibrahim, Marcel Jaspars, Margaret Smith, James Naismith, Jesko Koehnke, Andrew Bent, Nicholas Westwood
  • Publication number: 20150322474
    Abstract: This invention relates to the in vitro production of cyclic peptides using cyanobacterial enzymes, such as patellamide biosynthesis enzymes. Linear peptide substrates are cyclized using an isolated cyanbacterial macrocyclase, such as PatG from Prochloron spp. Before cyclisation, residues in the linear peptide substrates may be heterocyclised using isolated cyanbacterial heterocyclases, such as PatD or TruD heterocyclase. Methods of the invention may be useful, for example, for the production of cyclic peptidyl molecules, including cyclotides, such as katalas, and cyanobactins, such as patellamides and telomestatins, for example for use in the development of therapeutics.
    Type: Application
    Filed: June 28, 2013
    Publication date: November 12, 2015
    Applicants: The University of the University of Aberdeen, The University Court of the University of St. Andrews
    Inventors: Wael Houssen Ibrahim, Marcel Jaspars, Margaret Smith, James Naismith, Jesko Koehnke, Andrew Bent, Nicholas Westwood
  • Publication number: 20120123113
    Abstract: A method of producing a di-substituted pyridinium polymer by microwave-assisted polymerisation of a 2, 3, or 4-substituted pyridine monomer of the formula NC5R4—R?—X, wherein R is selected from hydrogen, hydroxyl, and substituted or unsubstituted alkyl, alkoxy, aryl, alkaryl, aralkyl, and alkenyl groups, R? is a linking group, and X is a leaving group. Using this method, di-substituted pyridinium polymer compositions may be obtained wherein at least 50% of the di- substituted pyridinium polymer chains in the composition have the same degree of polymerisation.
    Type: Application
    Filed: January 27, 2010
    Publication date: May 17, 2012
    Applicant: University Court of the University of Aberdeen
    Inventors: Marcel Jaspars, Wael Houssen, Zhibao Lu, Roderick Scott, RuAngelie Edrada-ebel, Ines Mancini
  • Publication number: 20070141707
    Abstract: The present invention relates to the use of sponge toxins, in particular polymeric 1,3-alkylpyridinium salts (poly-APS), for the reversible formation of membrane pores and a method for producing such pores.
    Type: Application
    Filed: June 21, 2004
    Publication date: June 21, 2007
    Applicant: ABERDEEN UNIVERSITY
    Inventors: H. Scott Roderick, Marcel Jaspars, Betina Platt, Gernot Reidel, Debra McLaggan, Kristina Sepcic
  • Publication number: 20060217558
    Abstract: A method of producing a linear di-substituted pyridinium compound of the formula NC5R4—R?-[-Q+NC5R4—R?—]n—X using a solid support, wherein n is an integer, R is selected from hydrogen, hydroxyl, and substituted or unsubstituted alkyl, alkoxy, aryl, alkaryl, aralkyl, and alkenyl groups, R? is a first linking group, and Q- and X are, respectively, a counter ion and a group which can react with the solid support.
    Type: Application
    Filed: June 21, 2004
    Publication date: September 28, 2006
    Inventor: Marcel Jaspars