Patents by Inventor Marcel Jozefonvicz

Marcel Jozefonvicz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymers substituted by groups conferring anti-coagulant properties on them, process for their preparation, articles and compositions made therefrom and uses thereof
    Patent number: 4755379
    Abstract: Anticoagulant products are constituted by polymers (homopolymers or copolymers) including in their chain substitutable groups on which are fixed statistically, groups X and/or Y and/or V, where X denotes the group --SO.sub.3 R.sub.1 or --R.sub.3 --SO.sub.3 R.sub.1, R.sub.1 being a hydrogen atom or a physiologically compatible metal, R.sub.3 being a --CH.sub.2 --CO--NH--R.sub.4 group in which R.sub.4 represensts an alkyl aryl or alkylaryl radical, which may or may not be substituted, or substituted or unsubstituted --CH.sub.2 --; Y denotes the group --SO.sub.2 --R.sub.2 or --R.sub.3 --SO.sub.2 --R.sub.2, R.sub.2 being the residue of an amino acid connected to the --SO.sub.2 bridge through its amine function and V denotes the group --CH.sub.2 --CO--NH--CHR--COOH, R being the side chain of an amino acid it being understood that: (a) if X is --SO.sub.3 R.sub.1 it is necessarily accompanied by Y and/or by V, and (b) V is always accompanied by X and/by Y.
    Type: Grant
    Filed: September 27, 1985
    Date of Patent: July 5, 1988
    Assignees: Jacqueline Jozefonvicz, Marcel Jozefonvicz, Christine Fougnot
    Inventors: Marcel Jozefonvicz, Jacqueline Jozefonvicz, Christine Fougnot, Monique Mauzac
  • Dextran derivatives endowed, particularly with anti-coagulant properties and anti-complementary properties, their preparation and their biological uses
    Patent number: 4740594
    Abstract: The dextran derivatives have a molecular weight higher than about 5000 daltons and comprise statistically at least about 35% of units substituted by radicals having a COO.sup.- function and at least 3% of units comprising a group of structure ##STR1## wherein R.sub.1 is a single bond; or a ##STR2## group, R.sub.2 is an anion of an inorganic or an organic salt and n is a number from 1 to 4.
    Type: Grant
    Filed: November 30, 1984
    Date of Patent: April 26, 1988
    Assignee: Choay S.A.
    Inventors: Monique Mauzac, Jacqueline Jozefonvicz, Marcel Jozefonvicz
  • Products based on polymers or copolymers substituted by groups having selective affinity towards products involved in blood plasma coagulation and process for preparing same
    Patent number: 4568725
    Abstract: Product constituted by a polymer or a copolymer having in its chain substitutable groups to which are statistically fixed X and Y groups, in which X represents SO.sub.3 --R.sup.1, with R.sup.1 being a hydrogen atom or a physiologically acceptable metal, wherein the Y groups have the formula --SO.sub.2 --R.sup.2, in which R.sup.2 represents a radical derived from arginine or an arginine derivative, bonded by its amino function --NH-- to the radical --SO.sub.2 --.The invention also relates to a process for preparing such a product and to a process of the separation and purification of thrombin.
    Type: Grant
    Filed: June 21, 1984
    Date of Patent: February 4, 1986
    Assignee: Commissariat a l'Energie Atomique
    Inventors: Catherine Boisson, Danielle Gulino, Jacqueline Jozefonvicz, Marcel Jozefonvicz
  • Method of determination for proteases and antiproteases
    Patent number: 4304853
    Abstract: A method for the determination of proteases and antiproteases, especially those of the blood clotting system and of the complement, is described, according to which a fragment liberated from a substrate by enzymatic hydrolysis is determined electrochemically.
    Type: Grant
    Filed: April 22, 1980
    Date of Patent: December 8, 1981
    Inventors: Marcel Jozefonvicz, Jean M. Nigretto